Intra-individual variation in creatinine and cystatin C

Bandaranayake, Niluka; Ankrah-Tetteh, Thelma; Wijeratne, Sethsiri; Swaminathan, R.

doi:10.1515/cclm.2007.256

Cited by 29 publications

(17 citation statements)

References 10 publications

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“…Our results thus indicate a considerable biological variation of s-Cys, independent of GFR. Repeated s-Cys determinations in 10 healthy young subjects showed a lower intra-individual variation of 4.55 % [27]. This lower variation can be explained by the variation of CL nr , which has less relative influence on s-Cys when GFR is normal than at lower values.…”

Section: Discussionmentioning

confidence: 82%

Cystatin C as a filtration marker – haemodialysis patients expose its strengths and limitations

Sjöström¹,

Jones

Tidman³

2009

Scandinavian Journal of Clinical and Laboratory Investigation

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Section: Discussionmentioning

confidence: 82%

Cystatin C as a filtration marker – haemodialysis patients expose its strengths and limitations

Sjöström¹,

Jones

Tidman³

2009

Scandinavian Journal of Clinical and Laboratory Investigation

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“…Because implementing manual adjudication in large-scale observational studies of AKI is not feasible, we sought to identify a quantitative rule that could be applied to a cohort of hospitalized patients to accurately classify changes in kidney function during hospitalization. The superiority of the mean outpatient creatinine in matching the adjudicated value may reflect a clinical recognition by the adjudicators that averaging multiple serum creatinine values, if available, reduces the inappropriate effect of outliers or the known effect of physiologic variation (18)(19)(20). This latter observation suggests that for a large proportion of patients at risk for AKI, baseline kidney function may be more accurately described as a range than as a single value.…”

Section: Discussionmentioning

confidence: 99%

Estimating Baseline Kidney Function in Hospitalized Patients with Impaired Kidney Function

Siew¹,

İkizler²,

Matheny

et al. 2012

Clinical Journal of the American Society of Nephrology

242

235

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SummaryBackground and objectives Inaccurate determination of baseline kidney function can misclassify acute kidney injury (AKI) and affect the study of AKI-related outcomes. No consensus exists on how to optimally determine baseline kidney function when multiple preadmission creatinine measurements are available.Design, setting, participants, & measurements The accuracy of commonly used methods for estimating baseline serum creatinine was compared with that of a reference standard adjudicated by a panel of board-certified nephrologists in 379 patients with AKI or CKD admitted to a tertiary referral center.Results Agreement between estimating methods and the reference standard was highest when using creatinine values measured 7-365 days before admission. During this interval, the intraclass correlation coefficient (ICC) for the mean outpatient serum creatinine level (0.91 [95% confidence interval (CI), 0.88-0.92]) was higher than the most recent outpatient (ICC, 0.84 [95% CI, 0.80-0.88]; P,0.001) and the nadir outpatient (ICC, 0.83 [95% CI, 0.76-0.87; P,0.001) serum creatinine. Using the final creatinine value from a prior inpatient admission increased the ICC of the most recent outpatient creatinine method (0.88 [95% CI,). Performance of all methods declined or was unchanged when the time interval was broadened to 2 years or included serum creatinine measured within a week of admission. ConclusionsThe mean outpatient serum creatinine measured within a year of hospitalization most closely approximates nephrologist-adjudicated serum creatinine values.

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“…This initial study has recently been refuted by works which have shown that the intra-individual variability of CysC, measured by the PENIA method with Siemens reagents is equivalent to that of creatinine (47,48).…”

Section: Intra-individual Variabilitymentioning

confidence: 99%

Cystatin C: current position and future prospects

Séronie-Vivien

Delanaye

Piéroni³

et al. 2008

Clinical Chemistry and Laboratory Medicine

164

145

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Cystatin C is a low-molecular-weight protein which has been proposed as a marker of renal function that could replace creatinine. Indeed, the concentration of cystatin C is mainly determined by glomerular filtration and is particularly of interest in clinical settings where the relationship between creatinine production and muscle mass impairs the clinical performance of creatinine. Since the last decade, numerous studies have evaluated its potential use in measuring renal function in various populations. More recently, other potential developments for its clinical use have emerged. This review summarises current knowledge about the physiology of cystatin C and about its use as a renal marker, either alone or in equations developed to estimate the glomerular filtration rate. This paper also reviews recent data about the other applications of cystatin C, particularly in cardiology, oncology and clinical pharmacology. Clin Chem Lab Med 2008;46:1664-86.

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Intra-individual variation in creatinine and cystatin C

Abstract: Intra-individual variations for serum creatinine and cystatin C were similar in healthy subjects.

Cited by 29 publications

References 10 publications

Cystatin C as a filtration marker – haemodialysis patients expose its strengths and limitations

Cystatin C as a filtration marker – haemodialysis patients expose its strengths and limitations

Estimating Baseline Kidney Function in Hospitalized Patients with Impaired Kidney Function

Cystatin C: current position and future prospects

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