Intra‐operative high‐resolution mapping of slow wave propagation in the human jejunum: Feasibility and initial results

Angeli, Timothy R.; O’Grady, Gregory; Vather, Ryash; Bissett, Ian; Cheng, LK

doi:10.1111/nmo.13310

Cited by 34 publications

(29 citation statements)

References 49 publications

(141 reference statements)

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“…However, in the rabbits the ileal frequency was found to be similar to that of pigs (10.5 cpm in rabbits vs 11.6 cpm in pigs). In comparison, the slow‐wave frequency in the proximal jejunum was higher in rabbits than in humans (9.8 ± 0.4 vs 16.8 ± 1.1 cpm) …”

Section: Discussionmentioning

confidence: 83%

“…The term pacemaker was used to describe the origin of slow‐wave activity in the duodenum recorded extracellularly. To date, HR mapping has been applied to several studies investigating the slow‐wave characteristics in the small intestine of animals and humans . It has shown that multiple pacemakers (ie, sites of slow‐wave initiation) exist along the intestine and the location of these pacemakers can move over .…”

Section: Introductionmentioning

confidence: 99%

“…Further studies have revealed the presence of dysrhythmic activity during the in vivo state and during diabetic states . In a recent study, in vivo HR mapping was performed intra‐operatively on normal human jejunum and revealed the presence of spatially complex slow‐wave patterns . Therefore, it remains unclear whether these complex slow‐wave propagation patterns are part of the normal regulatory activity of the small intestine or in fact correlated to abnormal intestinal function.…”

Section: Introductionmentioning

confidence: 99%

“…To date, HR mapping has been applied to several studies investigating the slow-wave characteristics in the small intestine of animals [24][25][26] and humans. 27 It has shown that multiple pacemakers (ie, sites of slow-wave initiation) exist along the intestine and the location of these pacemakers can move over. 1 Further studies have revealed the presence of dysrhythmic activity during the in vivo state and during diabetic states.…”

mentioning

confidence: 99%

“…24,26 In a recent study, in vivo HR mapping was performed intra-operatively on normal human jejunum and revealed the presence of spatially complex slow-wave patterns. 27 Therefore, it remains unclear whether these complex slow-wave propagation patterns are part of the normal regulatory activity of the small intestine or in fact correlated to abnormal intestinal function. Further intestinal HR slow-wave studies are necessary to elucidate the role that intestinal pacemakers, transient propagation patterns, and dysrhythmic slow-wave activity play in intestinal electrophysiology and function.…”

mentioning

confidence: 99%

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Dynamic slow‐wave interactions in the rabbit small intestine defined using high‐resolution mapping

Abraham

Cheng

Angeli

et al. 2019

Neurogastroenterology Motil

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Background The motility in the small intestine is governed in part by myogenic bio‐electrical events, known as slow waves. High‐resolution multi‐electrode mapping has improved our understanding of slow‐wave propagation in the small intestine but has been applied in a limited number of in vivo animal studies. This study applied high‐resolution mapping to investigate slow waves in the rabbit small intestine. Methods A high‐resolution flexible printed circuit board array (256 electrodes; 4 mm spacing) was applied in vivo to the rabbit intestine. Extracellular slow‐wave activity was acquired sequentially along the length of the intestine. Key results and conclusions The majority of the slow waves propagated in the antegrade direction (56%) while retrograde patterns were primarily observed in the distal intestine (29%). Colliding slow‐wave events were observed across the length of the small intestine (15%). The interaction of competing pacemakers was mapped in spatiotemporal detail. The frequency and velocity of the slow waves were highest in the duodenum compared to ileum (20.0 ± 1.2 cpm vs 10.5 ± 0.9 cpm, P < 0.001; 14.4 ± 3.4 mm/s vs 12.3 ± 3.4 mm/s; P < 0.05). Inferences In summary, extracellular serosal slow‐wave activity was quantified spatiotemporally along the length of the rabbit intestine. In particular, the study provides evidence toward the presence and interaction of slow‐wave pacemakers acting along the small intestine and how they may contribute to the slow‐wave frequency gradient along the length of the intestine.

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Section: Discussionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Dynamic slow‐wave interactions in the rabbit small intestine defined using high‐resolution mapping

Abraham

Cheng

Angeli

et al. 2019

Neurogastroenterology Motil

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A novel method for measuring bowel motility and velocity with dynamic magnetic resonance imaging in two and three dimensions

et al. 2021

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Increasingly, dynamic magnetic resonance imaging (MRI) has potential as a noninvasive and accessible tool for diagnosing and monitoring gastrointestinal motility in healthy and diseased bowel. However, current MRI methods of measuring bowel motility have limitations: requiring bowel preparation or long acquisition times; providing mainly surrogate measures of motion; and estimating bowel‐wall movement in just two dimensions. In this proof‐of‐concept study we apply a method that provides a quantitative measure of motion within the bowel, in both two and three dimensions, using existing, vendor‐implemented MRI pulse sequences with minimal bowel preparation. This method uses a minimised cost function to fit linear vectors in the spatial and temporal domains. It is sensitised to the spatial scale of the bowel and aims to address issues relating to the low signal‐to‐noise in high‐temporal resolution dynamic MRI scans, previously compensated for by performing thick‐slice (10‐mm) two‐dimensional (2D) coronal scans. We applied both 2D and three‐dimensional (3D) scanning protocols in two healthy volunteers. For 2D scanning, analysis yielded bi‐modal velocity peaks, with a mean antegrade motion of 5.5 mm/s and an additional peak at ~9 mm/s corresponding to longitudinal peristalsis, as supported by intraoperative data from the literature. Furthermore, 3D scans indicated a mean forward motion of 4.7 mm/s, and degrees of antegrade and retrograde motion were also established. These measures show promise for the noninvasive assessment of bowel motility, and have the potential to be tuned to particular regions of interest and behaviours within the bowel.

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Effects of Electrode Diameter and Contact Material on Signal Morphology of Gastric Bioelectrical Slow Wave Recordings

et al. 2020

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Intra‐operative high‐resolution mapping of slow wave propagation in the human jejunum: Feasibility and initial results

Cited by 34 publications

References 49 publications

Dynamic slow‐wave interactions in the rabbit small intestine defined using high‐resolution mapping

Dynamic slow‐wave interactions in the rabbit small intestine defined using high‐resolution mapping

A novel method for measuring bowel motility and velocity with dynamic magnetic resonance imaging in two and three dimensions

Effects of Electrode Diameter and Contact Material on Signal Morphology of Gastric Bioelectrical Slow Wave Recordings

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