Intra-operative identification of ureters using indocyanine green for gynecological oncology procedures

Cabanes, M.P. Fuset; Boria, Félix; Gutiérrez, Alicia Hernández; Zapardiel, Ignacio

doi:10.1136/ijgc-2019-000895

Cited by 22 publications

(18 citation statements)

References 4 publications

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“…This study was approved by the Ethical Committee of the hospital. Inclusion criteria: 1) Patients conforming to the diagnostic criteria of endometrial cancer (13,14) that was further confirmed by the pathological examination after the epifascial panhysterectomy; 2) patients with no history of the chemotherapy or radiotherapy before surgery; 3) patients with a Karnofsky score ≥70 points; 4) patients that agreed to participate in this study after they were informed of the content. Exclusion criteria: 1) Patients with an anomaly in routine examinations of blood, urine or feces, or in the function test of liver, kidney or heart; 3) patients with the contraindications of chemotherapy or radiotherapy; 3) patients complicated with other malignant tumors; 4) patients who were allergic to the drugs of this study.…”

Section: General Materialsmentioning

confidence: 99%

Comparison between Pelvic IMRT and 3D-CRT in Combination with Chemotherapy via Nrf2 Expression on the High-Risk Endometrial Cancer

Wang

Zhang

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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This study aimed to explore the clinical efficacy of pelvic intensity-modulated radiation therapy (IMRT) and 3-dimensional conformal radiotherapy (3D-CRT) in combination with chemotherapy on high-risk endometrial cancer. The effect of these methods is evaluated via Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) expression, the levels of chitinase protein 40 (YKL-40), human epididymis protein 4 (HE4), and prolactin (PRL) in serum. For this purpose, between August 2014 and July 2017, 114 endometrial cancer patients admitted to this hospital for treatment were randomized into the observation group (n=60) and control group (n=54). Following the surgery, patients in these two groups received the chemotherapy of taxol and carboplatin (TC). Based on the chemotherapy, patients in the observation underwent the IMRT, while those in the control group adopted the 3D-CRT. The Nrf2 expression was performed based on the Real-time PCR technique. The incidence rate of adverse reactions was a 3-year recurrence rate and mortality rate. Results showed that after treatment, levels of YKL-40, HE4, and PRL in the serum of patients in two groups decreased compared to those before treatment (all P < 0.05). In comparison, the difference between the two groups showed no statistical significance (P > 0.05). The evaluation of Nrf2 transcription factor expression showed significant differences started in comparisons of the Nrf2 Expression between two groups (P > 0.05), and this enhancement was significant in the control group after treatment. Comparison of the incidence rates of the bone marrow suppression during treatment showed no significant difference (P > 0.05). However, the incidence rates of radiation enteritis and radio-cystitis in the observation group were much lower than those in the control group (P < 0.05). During the follow-up, there were five patients in the control group and 7 in the observation group losing to the follow-up, and among the remaining subjects, no significant difference was identified in the comparison of the recurrence rate or mortality rate between the two groups (all P > 0.05). In general, Pelvic IMRT in combination with chemotherapy is a promising and safe candidate for high-risk endometrial cancer with mild radiation injury; besides, YKL-40, HE4, and PRL are the effective indicator for the prediction of efficacy in chemotherapy for endometrial cancer.

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Section: General Materialsmentioning

confidence: 99%

Comparison between Pelvic IMRT and 3D-CRT in Combination with Chemotherapy via Nrf2 Expression on the High-Risk Endometrial Cancer

Wang

Zhang

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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“…Cabanes et al 75 | 1695 fluorescence to detect peritoneal deposits from colorectal, ovarian, and hepatocellular carcinoma reported a wide variation in sensitivity from 72.4% to 100% and specificity from 54.2% to 100%, suggesting the need for further prospective studies to improve the diagnostic value and efficacy of ICG imaging. 83…”

Section: Identification Of Uretersmentioning

confidence: 99%

“…Cabanes et al 75 described fluorescent ureteral visualization technique by cystoscopic injection of ICG into the ureters. It remains in the ureters for about 6 hours and can be used to identify the ureters.…”

Section: Clinical Applications and Relevancementioning

confidence: 99%

Fluorescence‐guided cancer surgery—A new paradigm

Thammineedi

Saksena

Nusrath

et al. 2021

Journal of Surgical Oncology

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Fluorescence-guided surgery is an emerging and promising operative adjunct to assist the surgeon in various aspects of oncosurgery, ranging from assessing perfusion, identification, and characterization of tumors and peritoneal metastases, mapping of lymph nodes/leaks, and assistance for fluorescence-guided surgery (FGS). This study aims to provide an overview of principles, currently available dyes, platforms, and surgical applications and summarizes the available literature on the utility of FGS with a focus on abdomino-thoracic malignancies.

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“…In a group of 30 operations, the preoperative procedure of cystoscopy prolonged time over approximately 7 minutes and in 10 patients (33%); in case of difficulties to intraoperatively find the ureter in normal light, the fluorescence-guided identification made it possible to find its position faster [ 76 ]. In a group of 16 gynecologic oncology operations, all bilateral ureters were visualized after the cystoscopic insertion of 8 mL of ICG with 6 French ureteral catheters [ 77 ]. Fluorescence visualization of the ureters and the bladder was used during neovagina creation in congenital vaginal agenesis [ 78 ].…”

Section: Other Major Applications Of Icgmentioning

confidence: 99%

Comprehensive Review of Fluorescence Applications in Gynecology

Połom

Kalinowski

Diana

et al. 2021

JCM

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Since the introduction of indocyanine green (ICG) as a fluorophore in near-infrared imaging, fluorescence visualization has become an essential tool in many fields of surgery. In the field of gynecology, recent new applications have been proposed and found their place in clinical practice. Different applications in gynecology were investigated, subcategorized, and overviewed concerning surgical applications and available dyes. Specific applications in which fluorescence-guided surgery was implemented in gynecology are described in this manuscript—namely, sentinel node biopsy, mesometrium visualization, angiography of different organs, safety issues in pregnant women, ureters visualization, detection of peritoneal metastases, targeted fluorophores for cancer detection, fluorescent contamination hysterectomy, lymphography for lower limb lymphedema prevention, tumor margin detection, endometriosis, and metastases mapping. With evolving technology, further innovative research on the new applications of fluorescence visualization in cancer surgery may help to establish these techniques as standards of high-quality surgery in gynecology. However, more investigations are necessary in order to assess if these innovative tools can also be effective to improve patient outcomes and quality of life in different gynecologic malignancies.

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Intra-operative identification of ureters using indocyanine green for gynecological oncology procedures

Cited by 22 publications

References 4 publications

Comparison between Pelvic IMRT and 3D-CRT in Combination with Chemotherapy via Nrf2 Expression on the High-Risk Endometrial Cancer

Comparison between Pelvic IMRT and 3D-CRT in Combination with Chemotherapy via Nrf2 Expression on the High-Risk Endometrial Cancer

Fluorescence‐guided cancer surgery—A new paradigm

Comprehensive Review of Fluorescence Applications in Gynecology

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