Intra-ovarian roles of activins and inhibins

Knight, P. G.; Satchell, Leanne; Glister, Claire

doi:10.1016/j.mce.2011.04.024

Cited by 133 publications

(105 citation statements)

References 171 publications

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“…Activins A and B have various reproductive and metabolic actions in females. They stimulate follicular growth and also inhibit androgen production in the theca cells of the ovary (23). On the other hand, follistatin neutralises activin activity, and inhibits follicle stimulating hormone (FSH) secretion and folliculogenesis.…”

Section: Metabolic Markers Of Metabolic Syndrome In Pcosmentioning

confidence: 99%

What do we know about metabolic syndrome in adolescents with PCOS?

Cırık

Dilbaz

2014

J Turkish German Gynecol Assoc

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Section: Metabolic Markers Of Metabolic Syndrome In Pcosmentioning

confidence: 99%

What do we know about metabolic syndrome in adolescents with PCOS?

Cırık

Dilbaz

2014

J Turkish German Gynecol Assoc

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“…The activin pathway has been postulated to be involved in regulation of multiple reproductive processes including ovarian follicular development (Knight et al 2012), luteinisation of the follicular cells (Myers et al 2008, Kayani et al 2009), early embryo development (Rajput et al 2013) and uterine function during implantation of the conceptus (Singh et al 2011). As a member of the transforming growth factor beta superfamily of growth factors, activin forms from the dimerisation of two b-subunits of inhibin (INHB), with different combinations forming functionally different isoforms (Knight 1996, Mellor et al 2003.…”

Section: Introductionmentioning

confidence: 99%

Activin A and follistatin during the oestrous cycle and early pregnancy in ewes

O’Connell¹,

McNatty²,

Hurst³

et al. 2016

Journal of Endocrinology

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The activin pathway has been postulated to be involved in regulation of multiple reproductive processes important for survival of the conceptus. These processes include luteinisation of the follicular cells and thus function of the corpus luteum, early embryo development and uterine function including implantation of the conceptus. Therefore, the aim of the current study was to determine whether the concentrations of activin A and follistatin (FST), an activin-binding protein, differed between ewes with a lifetime history of enhanced or reduced embryonic survival (ES). The mRNAs encoding FST and activin A (inhibin beta A subunit; INHBA) were present in the uterus and abundant in the uterine luminal or glandular epithelia by day 18 of gestation. A peak of activin A was observed in the systemic circulation around the time of oestrus, and activin A concentrations were elevated in animals with reduced ES during the oestrous cycle and early gestation. Concentrations of activin A in uterine fluid were approximately twofold greater on day 16 of gestation in ewes with reduced ES compared to those with enhanced ES. No consistent differences in FST were observed between these groups. Treatment of luteinising ovine granulosa cells with activin A in vitro suppressed progesterone secretion providing evidence of a potential pathway whereby increased concentrations of activin A may decrease ES.

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“…In mouse embryos, the urogenital septum, developing pelvis and gonads are major sites for Fst and activin A mRNA expression (Day 12 post coitus), where they influence the development of the Müllerian duct (Feijen et al 1994;Hayashi et al 2003;Yao et al 2004). FST can modulate ovarian function by decreasing follicle stimulating hormone (FSH) and thus influencing follicle and corpus luteum development (reviewed by Knight et al 2012). Considerably less is known about the interactions of activin A and FST within the human uterus and fallopian tube, although these proteins are known to have key roles in the process of decidualisation and the establishment of pregnancy (Petraglia et al 1994;Jones et al 2002aJones et al , 2002bTierney and Giudice 2004;Refaat and Ledger 2011).…”

Section: Introductionmentioning

confidence: 99%

Follistatin is essential for normal postnatal development and function of mouse oviduct and uterus

Holdsworth-Carson

Craythorn

Winnall

et al. 2015

Reprod. Fertil. Dev.

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Abstract. Female mice lacking the follistatin gene but expressing a human follistatin-315 transgene (tghFST315) have reproductive abnormalities (reduced follicles, no corpora lutea and ovarian-uterine inflammation). We hypothesised that the absence of follistatin-288 causes the abnormal reproductive tract via both developmental abnormalities and abnormal ovarian activity. We characterised the morphology of oviducts and uteri in wild type (WT), tghFST315 and follistatinknockout mice expressing human follistatin-288 (tghFST288). The oviducts and uteri were examined in postnatal Day-0 and adult mice (WT and tghFST315 only) using histology and immunohistochemistry. Adult WT and tghFST315 mice were ovariectomised and treated with vehicle, oestradiol-17b (100 ng injection, dissection 24 h later) or progesterone (1 mg Â three daily injections, dissection 24 h later). No differences were observed in the oviducts or uteri at birth, but abnormalities developed by adulthood. Oviducts of tghFST315 mice failed to coil, the myometrium was disorganised, endometrial gland number was reduced and oviducts and uteri contained abundant leukocytes. After ovariectomy, tghFST315 mice had altered uterine cell proliferation, and inflammation was maintained and exacerbated by oestrogen. These studies show that follistatin is crucial to postnatal oviductal-uterine development and function. Further studies differentiating the role of ovarian versus oviductal-uterine follistatin in reproductive tract function at different developmental stages are warranted.

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Intra-ovarian roles of activins and inhibins

Cited by 133 publications

References 171 publications

What do we know about metabolic syndrome in adolescents with PCOS?

What do we know about metabolic syndrome in adolescents with PCOS?

Activin A and follistatin during the oestrous cycle and early pregnancy in ewes

Follistatin is essential for normal postnatal development and function of mouse oviduct and uterus

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