Intra-prostatic injection of botulinum toxin type A in treatment of dogs with spontaneous benign prostatic hyperplasia

Semen parameters and seminal plasma protein and biochemical profiles of dogs with benign prostatic hyperplasia after botulinum toxin type A intraprostatic injection

“…Botulinum toxin type A is the strongest biological neurotoxin known to man, however in our study, as well as in previous ones the therapeutic use of BT-A for BPH treatment showed to be safe and easy to perform (BRISINDA et al, 2011;MOSTACHIO et al, 2012). In previous studies, intraprostatic injection of 100UI and 200UI of Botox induced prostate atrophy and apoptosis in dogs (CHUANG et al, 2006) and relieved bladder outlet obstruction and improved clinical symptoms in men (CHUANG et al, 2005;KUO, 2005).…”

“…In previous studies, intraprostatic injection of 100UI and 200UI of Botox induced prostate atrophy and apoptosis in dogs (CHUANG et al, 2006) and relieved bladder outlet obstruction and improved clinical symptoms in men (CHUANG et al, 2005;KUO, 2005). ROSALES (2006) described a conversion ratio of Botox: Dysport of 1:2.5 and once 250UI BT-A (Dysport) treatment did not cause changes on semen parameters (MOSTACHIO et al, 2012) we opted by using the same BT-A concentration, as well as a higher therapeutic dosage of 500UI of Dysport to compare semen parameters data and to assess seminal plasma ionic and protein profi les.…”

“…Recently, our research group described that 250UI BT-A treatment did not affect the libido and semen quality in dogs with BPH (MOSTACHIO et al, 2012). Thus, considering that sperm function is highly dependent on ionic and protein environment (HAMAMAH & GATTI, 1998) and seminal plasma plays an important role on in vivo fertility (SOUZA et al, 2007) we hypothized if BT-A treatment could cause changes on the seminal plasma ionic and protein profi les of dogs with BPH.…”

Administração de toxina botulínica A e a orquiectomia no tratamento da hiperplasia prostática benigna do cão

“…Entretanto, doses de 250 unidades não foram utilizadas, uma vez que seus resultados não foram significativos em estudo prévio (MOSTACHIO et al, 2012).…”

“…Em homens, a administração de TB-A, intraprostaticamente, tem propiciado excelentes resultados, com uma rápida e segura redução do volume do órgão, além de ser adequada naqueles com riscos por problemas pré-existentes (MARIA et al, 2003;KUO, 2005). Entretanto, a influência dessa neurotoxina foi pouco estudada no cão, existindo poucos relatos de sua utilização (CHUANG et al 2006b;MOSTACHIO et al, 2012). Segundo CHUANG et al (2006b), as avaliações histopatológicas do tecido evidenciaram aumento no número de células apoptóticas e subsequente redução do volume prostático.…”