Intra-uterine exposure to maternal opiate abuse and HIV: The impact on the developing nervous system

Palchik, Alexander B.; Einspieler, Christa; Evstafeyeva, Irina V.; Talisa, Victor B.; Marschik, Peter B.

doi:10.1016/j.earlhumdev.2013.02.004

Cited by 24 publications

(16 citation statements)

References 42 publications

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“…The predictive power of abnormal fidgety movements is known to be low, 8,9 although a considerable number of infants with abnormal fidgety movements were described among individuals prenatally exposed to maternal opiate abuse and/or HIV who ultimately developed various neurodevelopmental and psychiatric impairments. 30 …”

Section: Discussionmentioning

confidence: 99%

Association of Infants Exposed to Prenatal Zika Virus Infection With Their Clinical, Neurologic, and Developmental Status Evaluated via the General Movement Assessment Tool

Utsch²,

et al. 2019

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Key PointsQuestionIs there an association between general movement assessment results and neurodevelopment in infants with vertical Zika virus exposure?FindingsIn this cohort study of 444 children, including 111 prenatally exposed to acute maternal illness with rash during the Zika epidemic, general movement assessment was associated with neurodevelopment at age 12 months (94% negative predictive value, 78% positive predictive value, 70% sensitivity, 96% specificity, and 91% accuracy). The Motor Optimality Score was 23 in children with normal development, 12 in children with adverse outcomes, and 5 in children with microcephaly, a significant difference.MeaningGeneral movement assessment is a helpful tool in the evaluation of neurodevelopment in Zika virus–exposed children.

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Section: Discussionmentioning

confidence: 99%

Association of Infants Exposed to Prenatal Zika Virus Infection With Their Clinical, Neurologic, and Developmental Status Evaluated via the General Movement Assessment Tool

Utsch²,

et al. 2019

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“…20 Abnormal FMs have been described in infants with trisomy 21 (Down syndrome) 21,22 and infants intra-uterinely exposed to maternal opiate abuse and/or HIV. 23 The predictive value of abnormal FMs is low. Infants with abnormal FMs may develop normally, 6,18,24,25 but could also develop CP.…”

Section: Normal Fmsmentioning

confidence: 96%

Fidgety movements – tiny in appearance, but huge in impact

Einspieler

Peharz

Marschik

2016

Jornal de Pediatria

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131

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Abnormal, absent, or sporadic FMs indicate an increased risk for later neurological dysfunction, whereas normal FMs are highly predictive of normal development, especially if they co-occur with other smooth and fluent movements. Early recognition of neurological signs facilitates early intervention. It is important to re-assure parents of infants with clinical risk factors that the neurological outcome will be adequate if FMs develop normally.

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“…Specifically, the absence of fidgety movements (at 3–5 months) is typically associated with the development of cerebral palsy [37, 41, 42]. In addition to its application in infants with perinatal brain injury, the general movement assessment (GMA) has also been applied to—for example—intrauterine HIV-exposed and/or HIV-infected newborns and young infants [43], infants of mothers with ZIKV infection [44], infants with metabolic disorders [45], infants with genetic disorders [46–49] and infants with ASD [50•, 51]. …”

Section: Introductionmentioning

confidence: 99%

A Novel Way to Measure and Predict Development: A Heuristic Approach to Facilitate the Early Detection of Neurodevelopmental Disorders

Marschik

Pokorny

Peharz

et al. 2017

Curr Neurol Neurosci Rep

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Purpose of ReviewSubstantial research exists focusing on the various aspects and domains of early human development. However, there is a clear blind spot in early postnatal development when dealing with neurodevelopmental disorders, especially those that manifest themselves clinically only in late infancy or even in childhood.Recent FindingsThis early developmental period may represent an important timeframe to study these disorders but has historically received far less research attention. We believe that only a comprehensive interdisciplinary approach will enable us to detect and delineate specific parameters for specific neurodevelopmental disorders at a very early age to improve early detection/diagnosis, enable prospective studies and eventually facilitate randomised trials of early intervention.SummaryIn this article, we propose a dynamic framework for characterising neurofunctional biomarkers associated with specific disorders in the development of infants and children. We have named this automated detection ‘Fingerprint Model’, suggesting one possible approach to accurately and early identify neurodevelopmental disorders.

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Intra-uterine exposure to maternal opiate abuse and HIV: The impact on the developing nervous system

Cited by 24 publications

References 42 publications

Association of Infants Exposed to Prenatal Zika Virus Infection With Their Clinical, Neurologic, and Developmental Status Evaluated via the General Movement Assessment Tool

Association of Infants Exposed to Prenatal Zika Virus Infection With Their Clinical, Neurologic, and Developmental Status Evaluated via the General Movement Assessment Tool

Fidgety movements – tiny in appearance, but huge in impact

A Novel Way to Measure and Predict Development: A Heuristic Approach to Facilitate the Early Detection of Neurodevelopmental Disorders

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