Intracardiac Catheter as a Foreign Body of Six Years' Duration Resulting in Endocarditis

Silver, Walter; DeGuzman, Aurora; Joos, Howard A.; Garzon, Antonio A.

doi:10.1378/chest.59.3.344

Cited by 5 publications

(2 citation statements)

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“…Although some form of penicillin is most often employed in prophylaxis, situa The results of attempted prophylaxis with the bacteriostatic drugs erythromycin, tetracycline, and clindamycin are summarized in Table II. Vegetations from all rabbits which received these drugs were found to be infected at the end of 24 h.…”

Section: Results Of Attemptedmentioning

confidence: 99%

“…3 It is, of course, possible that regimens which were ineffective in the presence of a catheter might have been successful if the foreign body had been withdrawn before bacteria were introduced. Nevertheless, it must be recognized that bacterial endocarditis now often affects patients who have prosthetic valves, or intracardiac catheters (23)(24)(25)(26). The point to be emphasized is that these experiments have defined the conditions under which a short course of antimicrobial therapy can prevent bacterial endocarditis even in the presence of a foreign body.…”

Section: Results Of Attemptedmentioning

confidence: 99%

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Chemotherapy of Experimental Streptococcal Endocarditis. I. COMPARISON OF COMMONLY RECOMMENDED PROPHYLACTIC REGIMENS

Durack¹,

Petersdorf²

1973

J. Clin. Invest.

181

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The effectiveness of various antibiotics commonly recommended for the prophylaxis of bacterial endocarditis has been evaluated in experimental streptococcal endocarditis in rabbits. High doses of penicillin G did not prevent the development of this infection. The only consistently successful prophylactic regimens using penicillin alone were those which provided for both an early high serum level and more than 9 h of effective antimicrobial action. Vancomycin was the only other drug which proved uniformly successful when given alone, even though the duration of its antimicrobial action in the blood was only 3 h. However, combined therapy using penicillin G or ampicillin with streptomycin was always effective in prophylaxis. Treatment with single injections of ampicillin, cephaloridine, cephalexin, clindamycin, cotrimoxazole, rifampicin, streptomycin, erythromycin, and tetracycline failed to prevent infection.The findings provide information on the effect of antimicrobials in vivo and may be applicable to the chemoprophylaxis of infective endocarditis in clinical practice.

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Section: Results Of Attemptedmentioning

confidence: 99%