Intracarotid Injection of Sodium Amytal for the Lateralization of Cerebral Speech Dominance

Wada, Juhn A.; Rasmussen, Theodore P.

doi:10.3171/jns.1960.17.2.0266

Cited by 1,458 publications

(426 citation statements)

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“…All patients and controls were right-handed. The patients underwent a presurgical language and memory evaluation with the IAP (Wada and Rasmussen, 1960). During the IAP amobarbital, a short acting anaesthetic, is injected in one of the internal carotid arteries producing a transient anaesthesia of the territories of the middle and anterior cerebral arteries of the ipsilateral hemisphere.…”

Section: Subjectsmentioning

confidence: 99%

Language activation distributions revealed by fMRI in post-operative epilepsy patients: Differences between left- and right-sided resections

et al. 2005

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Objective: To reveal differences of cerebral activation related to language functions in post-operative temporal lobe epilepsy (TLE) patients. Methods: Right (RTL) and left temporal lobe (LTL) resected patients, and healthy controls were studied using functional magnetic resonance imaging (fMRI). Only patients with complete left-hemispheric language dominance according to the intracarotid amytal procedure (IAP) were included. Language-related activations were evoked by performing word generation and text reading language tasks. Activation lateralization and temporo-frontal distribution effects were analysed. Results: For word generation, only LTL patients showed reduced left lateralized activation compared to controls, due to a decrease in activation in the left prefrontal cortex and an increase in the right prefrontal cortex. For reading, the left-hemispheric lateralization in RTL patients increased because of enhanced activity in the left prefrontal cortex, whereas for LTL patients the activation became bilaterally distributed over the temporal lobes. Lateralization results between pre-operative IAP and postoperative fMRI were highly discordant. Significant temporo-frontal distribution changes manifested from the reading but not from the word generation task. * Corresponding author. Backes et al. / Epilepsy Research 66 (2005) [1][2][3][4][5][6][7][8][9][10][11][12] Conclusion: The cerebral language representation in post-operative LTL epilepsy patients is more bi-hemispherically lateralized than in controls and RTL patients. Post-operative temporo-frontal and interhemispheric redistribution effects, involving contralateral homologuous brain areas, are suggested to contribute to the cerebral reorganisation of language function.

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Section: Subjectsmentioning

confidence: 99%

Language activation distributions revealed by fMRI in post-operative epilepsy patients: Differences between left- and right-sided resections

et al. 2005

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“…Data from patients who have undergone section of the corpus callosum (Sperry & Gazzaniga, 1967) and results from intracarotid injections of sodium amytal (Milner et al, 1966;Wada & Rasmussen, 1960) confirm this localization. Usually, only the left hemisphere can speak, the right being mute.…”

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confidence: 90%

Interhemispheric transmission of information: Measurement in normal man

Moscovitch

Catlin

1970

Psychon Sci

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“…Traditionally, this was accomplished using the intracarotid amobarbital test [6], considered to be the gold standard for language lateralization. More recently, fMRI has become the modality of choice for non-invasive localization [7].…”

Section: Introductionmentioning

confidence: 99%

Localization of Broca's area using verb generation tasks in the MEG: Validation against fMRI

Pang

Wang

Malone

et al. 2011

Neuroscience Letters

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Functional MRI (fMRI) is routinely used to non-invasively localize language areas. Magnetoencephalography (MEG) is being explored as an alternative technique. MEG tasks to localize receptive language are well established although there are no standardized tasks to localize expressive language areas. We developed two expressive language tasks for MEG and validated their localizations against fMRI data. Ten right-handed adolescents (μ=17.5 years) were tested with fMRI and MEG on two tasks: verb generation to pictures and verb generation to words. MEG and fMRI data were normalized and overlaid. The number of overlapping voxels activated in fMRI and MEG were counted for each subject, for each task, at different thresholding levels. For picture verb generation, there was 100% concordance between MEG and fMRI lateralization, and for word verb generation, there was 75% concordance. A count showed 79.6% overlap of voxels activated by both MEG and fMRI for picture verb generation and 50.2% overlap for word verb generation. The percentage overlap decreased with increasingly stringent activation thresholds. Our novel MEG expressive language tasks successfully identified neural regions involved in language production and showed high concordance with fMRI laterality. Percentage overlap of activated voxels was also high when validated against fMRI, but showed task-specific and threshold-related effects. The high concordance and high percentage overlap between fMRI and MEG activations confirm the validity of our new MEG task. Furthermore, the higher concordance from the picture verb generation task suggests that this is a promising task for use in the young clinical population.

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Intracarotid Injection of Sodium Amytal for the Lateralization of Cerebral Speech Dominance

Cited by 1,458 publications

References 4 publications

Language activation distributions revealed by fMRI in post-operative epilepsy patients: Differences between left- and right-sided resections

Language activation distributions revealed by fMRI in post-operative epilepsy patients: Differences between left- and right-sided resections

Interhemispheric transmission of information: Measurement in normal man

Localization of Broca's area using verb generation tasks in the MEG: Validation against fMRI

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