Intracellular accumulation and immunological response of NIR-II polymeric nanoparticles

Moskalevska, Iryna; Faure, Virginie; Haye, Lucie; Mercey-Ressejac, Marion; Dey, Arindam K.; Chovelon, Benoît; Soro, Lohona K.; Charbonnière, Loı̈c J.; Reisch, Andreas; Klymchenko, Andrey S.; Marche, Patrice N.; Coll, Jean‐Luc; Jílková, Zuzana Macek; Guével, Xavier Le

doi:10.1016/j.ijpharm.2022.122439

Cited by 4 publications

(1 citation statement)

References 55 publications

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“…At the same time, increasing the loading with AuNCs and further developments in the design of the AuNCs to achieve higher QYs, notably through optimization of the ligand sphere, should allow further optimizing their brightness for precise single‐particle tracking applications deep inside complex biological tissues. Analysis of the biological response to similar particles showed that these did not cause any adverse effect, [ 43 ] opening the way for applications in complex biological systems. More generally, this study should contribute to the development of novel contrast agents for biological and medical imaging.…”

Section: Discussionmentioning

confidence: 99%

Expanding the Palette of SWIR Emitting Nanoparticles Based on Au Nanoclusters for Single‐Particle Tracking Microscopy

Simon,

Haye,

Alhalabi

et al. 2024

Advanced Science

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Single‐molecule localization microscopy has proved promising to unravel the dynamics and molecular architecture of thin biological samples down to nanoscales. For applications in complex, thick biological tissues shifting single‐particle emission wavelengths to the shortwave infrared (SWIR also called NIR II) region between 900 to 2100 nm, where biological tissues are more transparent is key. To date, mainly single‐walled carbon nanotubes (SWCNTs) enable such applications, but they are inherently 1D objects. Here, 0D ultra‐small luminescent gold nanoclusters (AuNCs, <3 nm) and ≈25 nm AuNC‐loaded‐polymeric particles that can be detected at the single‐particle level in the SWIR are presented. Thanks to high brightness and excellent photostability, it is shown that the dynamics of the spherical polymeric particles can be followed at the single‐particle level in solution at video rates for minutes. We compared single particle tracking of AuNC‐loaded‐polymeric particles with that of SWCNT diffusing in agarose gels demonstrating the specificity and complementarity of diffusion properties of these SWIR‐emitting nano‐objects when exploring a complex environment. This extends the library of photostable SWIR emitting nanomaterials to 0D nano‐objects of variable size for single‐molecule localization microscopy in the second biological window, opening unprecedented possibilities for mapping the structure and dynamics of complex biological systems.

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Section: Discussionmentioning

confidence: 99%

Expanding the Palette of SWIR Emitting Nanoparticles Based on Au Nanoclusters for Single‐Particle Tracking Microscopy

Simon,

Haye,

Alhalabi

et al. 2024

Advanced Science

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Engineering Radiocatalytic Nanoliposomes with Hydrophobic Gold Nanoclusters for Radiotherapy Enhancement

Carigga Gutierrez,

Clainche,

Bulin

et al. 2024

Advanced Materials

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Chemoradiation therapy is on the forefront of pancreatic cancer care, and there is a continued effort to improve its safety and efficacy. Liposomes are widely used to improve chemotherapy safety, and may accurately deliver high‐Z element‐ radiocatalytic nanomaterials to cancer tissues. In this study, the interaction between X‐rays and long‐circulating nanoliposome formulations loaded with gold nanoclusters is explored in the context of oxaliplatin chemotherapy for desmoplastic pancreatic cancer. Hydrophobic gold nanoclusters stabilized with dodecanethiol (AuDDT) are efficiently incorporated in nanoliposomal bilayers. AuDDT‐nanoliposomes significantly augmented radiation‐induced •OH production, which is most effective with monochromatic X‐rays at energies that exceed the K‐shell electron binding energy of Au (81.7 keV). Cargo release assays reveal that AuDDT‐nanoliposomes can permeabilize lipid bilayers in an X‐ray dose‐ and formulation‐dependent manner. The radiocatalytic effect of AuDDT‐nanoliposomes significantly augments radiotherapy and oxaliplatin‐chemoradiotherapy outcomes in 3D pancreatic microtumors. The PEGylated AuDDT‐nanoliposomes display high tumor accumulation in an orthotopic mouse model of pancreatic cancer, showing promise for nanoliposomes as carriers for radiocatalytic nanomaterials. Altogether, compelling proof for chemo‐radiation dose‐enhancement using AuDDT‐nanoliposomes is presented. Further improving the nanoliposomal loading of high‐Z elements will advance the safety, efficacy, and translatability of such chemoradiation dose‐enhancement approaches.

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Ratiometric fluorescent detection of exosomal piRNA-823 based on Au NCs/UiO-66-NH2 and target-triggered rolling circle amplification

Tong

Guan

Sun

et al. 2023

Talanta

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Intracellular accumulation and immunological response of NIR-II polymeric nanoparticles

Cited by 4 publications

References 55 publications

Expanding the Palette of SWIR Emitting Nanoparticles Based on Au Nanoclusters for Single‐Particle Tracking Microscopy

Expanding the Palette of SWIR Emitting Nanoparticles Based on Au Nanoclusters for Single‐Particle Tracking Microscopy

Engineering Radiocatalytic Nanoliposomes with Hydrophobic Gold Nanoclusters for Radiotherapy Enhancement

Ratiometric fluorescent detection of exosomal piRNA-823 based on Au NCs/UiO-66-NH2 and target-triggered rolling circle amplification

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