1994
DOI: 10.1016/0167-4889(94)90030-2
|View full text |Cite
|
Sign up to set email alerts
|

Intracellular concentrations of inositol, glycerophosphoinositol and inositol pentakisphosphate increase during haemopoietic cell differentiation

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

2
19
0

Year Published

1996
1996
2012
2012

Publication Types

Select...
6
3

Relationship

0
9

Authors

Journals

citations
Cited by 35 publications
(21 citation statements)
references
References 37 publications
2
19
0
Order By: Relevance
“…IP 5 is known to increase during hematopoietic cell differentiation and accumulates at higher concentrations than IP 3 and IP 4 (20). These observations raised the possibility that IP 5 is a physiological ligand and activates Btk function in vivo, although the activation mechanism remains unknown.…”
Section: Discussionmentioning
confidence: 88%
“…IP 5 is known to increase during hematopoietic cell differentiation and accumulates at higher concentrations than IP 3 and IP 4 (20). These observations raised the possibility that IP 5 is a physiological ligand and activates Btk function in vivo, although the activation mechanism remains unknown.…”
Section: Discussionmentioning
confidence: 88%
“…Moreover, importantly, the concentrations of exogenous GroPIns-4-P active on cAMP are in the low micromolar range (1-100 ,uM), which is also the range of the estimated concentration of GroPIns-4-P in Rastransformed thyroid cells (Iacovelli et al, 1993) and, most likely, of the levels of GroPIns-4-P formed intracellularly in response to EGF in fibroblasts (the latter are similar to those of Ins-1,4,5-P3, i.e., in the micromolar range; Irvine, 1989;Bunce et al, 1993;Mountford et al, 1994). Thus, collectively, the above findings argue rather compellingly that GroPIns-4-P formed by EGF can result in the inhibition of adenylyl cyclase.…”
Section: Discussionmentioning
confidence: 93%
“…The intracellular concentrations of GroPIns have also been confirmed by MS [12,13], showing that it varies across different cell types in the range of low-micromolar to almost millimolar levels (from 40 to 900 μM), and it can be modulated according to the state of cell stimulation, activation, differentiation and transformation [1,9,11,[14][15][16]. On the other hand, the intracellular levels of GroPIns4P and GroPIns(4,5)P 2 are at least 10-and 100-fold lower respectively than that of GroPIns, as can be extrapolated from HPLC analysis following cell extraction after equilibrium labelling with [ 3 H]myo-inositol (see [10] and references therein).…”
Section: Metabolism Of the Glycerophosphoinositolsmentioning
confidence: 87%