Intracellular Cytokine Production in Peripheral Blood Lymphocytes: A Comparison of Values in Infertile and Fertile Women

Horká, Petra; Jarosová, R; Malíčková, Karin; Janatková, I; Marecková, H; Zima, Tomáš; Kalousová, Marta

doi:10.1111/j.1600-0897.2010.00959.x

Cited by 12 publications

(3 citation statements)

References 19 publications

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“…Interestingly, IL-6 levels were posited to play a role in unexplained infertility; women with infertility showed significantly higher IL-6 levels when compared with the fertile group (66). With regard to TNF, infertile women had a greater intracellular (IC) production of TNF- α, and higher ratios of TNF- α/IL-2, TNF- α/IL-4, TNF- α/ IFN-γ when compared to the fertile group (67). Idiopathic infertile and immune-infertile groups showed greater TNF- α concentrations from cervical mucus (but not from sera) compared to fertile groups, with immune-infertile groups having greater TNF- α concentrations compared to the idiopathic groups (68).…”

Section: How Might Sleep Affect Fertility?mentioning

confidence: 99%

Sleep, sleep disturbance, and fertility in women

Kloss¹,

Perlis²,

Zamzow³

et al. 2015

Sleep Medicine Reviews

159

102

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Summary Sleep and sleep disturbances are increasingly recognized as determinants of women’s health and well-being, particularly in the context of the menstrual cycle, pregnancy, and menopause. At present, however, little is known about whether fertility is affected by sleep quantity and quality. That is, to what degree, and by what mechanisms, do sleep and/or its disturbances affect fertility? The purpose of this review is to synthesize what is known about sleep disturbances in relation to reproductive capacity. A model is provided, whereby stress, sleep dysregulation, and circadian misalignment are delineated for their potential relevance to infertility. Ultimately, if it is the case that sleep disturbance is associated with infertility, new avenues for clinical intervention may be possible.

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Section: How Might Sleep Affect Fertility?mentioning

confidence: 99%

Sleep, sleep disturbance, and fertility in women

Kloss¹,

Perlis²,

Zamzow³

et al. 2015

Sleep Medicine Reviews

159

102

View full text Add to dashboard Cite

show abstract

“…Some studies speculate that insufficient sleep may affect women's fertility through impaired immunity ( 47 ). During sleep deprivation, increased cytokine and immune inflammatory reaction marked by TNF and IL-6 were observed ( 53 – 55 ), high levels of IL-6 and TNF were considered to be related to female infertility ( 56 , 57 ). In a previous study of males, it was found that a short sleep duration was associated with a reduction in semen quality ( 58 – 61 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of physical activity and sleep duration on fertility: A systematic review and meta-analysis based on prospective cohort studies

Zhao

Xiang

Wang

et al. 2022

Front. Public Health

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ObjectiveSubfertility is a common problem for couples in modern society. Many studies have confirmed that lifestyle factors can affect fertility although there are conflicting conclusions relating to the effects of physical activity and sleep duration on fertility. In this study, we aimed to summarize and analyze the available evidence.MethodsPubMed, Web of Science, Cochrane, and Embase databases (as of October 14, 2022) were systematically searched for eligible prospective cohort studies. Data were extracted and effect values were combined. We also performed methodological quality and bias risk assessments for all the included studies.ResultsA total of 10 eligible articles were included in our analysis; seven investigated the relationship between physical activity and fertility, and three investigated the effect of sleep duration on fertility. Compared with the lowest level of physical activity, high intensity physical activity (the highest levels of physical activity) was negatively correlated with fertility [odds ratio (OR) = 0.84; 95% confidence interval (CI): 0.70, 1.00, I2 = 64%]. However, we did not find an association between moderate intensity physical activity and fertility (OR = 1.09; 95% CI: 0.98, 1.22, I2 = 60%). We observed an inverse association between limited sleep duration (≤ 7 h) and fertility (OR = 0.92; 95% CI: 0.84, 1.00, I2 = 0%) compared with 8 h of sleep. The relationship between long sleep duration (≥9 h) and fertility was not statistically significant (OR = 0.85; 95% CI: 0.60, 1.21, I2 = 83%). According to the Newcastle-Ottawa Scale score, the overall quality of the research articles included was ranked as medium to high (6–9). Through GRADE system, the quality of evidence for the impact of high intensity physical activity and limited sleep duration on fertility was moderate, while the quality of evidence for the impact of moderate intensity physical activity and long sleep duration on fertility was low.ConclusionThe current evidence shows that high intensity physical activity and limited sleep time are negatively related to fertility. But there was great heterogeneity among studies, and the quality of research evidence was low to median. Thus, further high-quality research is needed to confirm this conclusion.PROSPERO registration numberCRD42022298137.

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“…Ως προς την ενδοκυττάρια παραγωγή κυτταροκινών, σε πρόσφατη in vitro μελέτη με λεμφοκύτταρα υπογόνιμων γυναικών, διαπιστώθηκε στατιστικά σημαντική αύξηση της ενδοκυττάριας παραγωγής TNF-, IL-2, IFNαλλά και IL-4, καθώς και υψηλότεροι λόγοι TNF-α/IL-2, TNF-α/IL-4 και TNFα/IFN-γ συγκριτικά με την ομάδα γόνιμων γυναικών 160 .…”

Section: συζητησηunclassified

Έλεγχος Γονιδιακού Πολυμορφισμού Κυτταροκινών Σε Δείγμα Γυναικών Του Ελληνικού Πληθυσμού Με Επαναλαμβανόμενες Αποβολές

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Intracellular Cytokine Production in Peripheral Blood Lymphocytes: A Comparison of Values in Infertile and Fertile Women

Abstract: Cytokines produced by Th lymphocytes are important in orchestrating the immune response during conception, and Th-cell dysregulation could be a reason for infertility.

Cited by 12 publications

References 19 publications

Sleep, sleep disturbance, and fertility in women

Sleep, sleep disturbance, and fertility in women

Effects of physical activity and sleep duration on fertility: A systematic review and meta-analysis based on prospective cohort studies

Έλεγχος Γονιδιακού Πολυμορφισμού Κυτταροκινών Σε Δείγμα Γυναικών Του Ελληνικού Πληθυσμού Με Επαναλαμβανόμενες Αποβολές

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