Intracellular delivery cellulose-based bionanogels with dual temperature/pH-response for cancer therapy

Wen, Yifen; Oh, Jung Kwon

doi:10.1016/j.colsurfb.2015.06.017

Cited by 40 publications

(22 citation statements)

References 60 publications

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“…The use of thermo-responsive hydrogels as administration systems for chemotherapeutic agents started from the fact that they can be injected directly into the tumor, in liquid form, and then, in the presence of body temperature, become gel [127]. pH-responsive hydrogels have also been researched for anticancer drug delivery benefiting from the pH difference between the tumor environment (pH = 5-6) and physiological pH of 7.4 ( Figure 13) [132]. In order to establish the controlled release capacity of the drugs, the release of tenofovir, a drug used to treat human immunodeficiency virus (HIV), was investigated.…”

Section: Cellulose Based-hydrogels As Delivery Systems In Cancer Therapymentioning

confidence: 99%

“…Well-defined dual temperature/acidic pH-responsive nanogels (DuR-BNGs) were synthesized by crosslinking polymerization via the temperature-driven self-association method in aqueous solution ( Figure 13) [132]. CMC contains pendant COOH groups that promote the release of encapsulated anticancer drugs in acidic tumor tissues, namely pH of 5.0-6.5 compared with pH 6.5 in extracellular environments.…”

Section: Cellulose Based-hydrogels As Delivery Systems In Cancer Therapymentioning

confidence: 99%

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Cellulose-Based Hydrogels as Sustained Drug-Delivery Systems

Ciolacu¹,

Nicu²,

Ciolacu

2020

Materials

140

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Hydrogels, three-dimensional (3D) polymer networks, present unique properties, like biocompatibility, biodegradability, tunable mechanical properties, sensitivity to various stimuli, the capacity to encapsulate different therapeutic agents, and the ability of controlled release of the drugs. All these characteristics make hydrogels important candidates for diverse biomedical applications, one of them being drug delivery. The recent achievements of hydrogels as safe transport systems, with desired therapeutic effects and with minimum side effects, brought outstanding improvements in this area. Moreover, results from the utilization of hydrogels as target therapy strategies obtained in clinical trials are very encouraging for future applications. In this regard, the review summarizes the general concepts related to the types of hydrogel delivery systems, their properties, the main release mechanisms, and the administration pathways at different levels (oral, dermal, ocular, nasal, gastrointestinal tract, vaginal, and cancer therapy). After a general presentation, the review is focused on recent advances in the design, preparation and applications of innovative cellulose-based hydrogels in controlled drug delivery.

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Section: Cellulose Based-hydrogels As Delivery Systems In Cancer Therapymentioning

confidence: 99%

Section: Cellulose Based-hydrogels As Delivery Systems In Cancer Therapymentioning

confidence: 99%

Cellulose-Based Hydrogels as Sustained Drug-Delivery Systems

Ciolacu¹,

Nicu²,

Ciolacu

2020

Materials

140

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“…56 The percentage of free BSA was calculated as the wt ratio of BSA in the supernatants of the mixtures containing Dox-loaded micelles to that in control (with no Dox-loaded micelles). and used to determine the content as wt of BSA in the supernatants using a calibration curve.…”

Section: Reduction-responsive Degradation Of Aqueous Micelles In the mentioning

confidence: 99%

Rosin-based block copolymer intracellular delivery nanocarriers with reduction-responsive sheddable coronas for cancer therapy

Hong

Tang

et al. 2016

Polym. Chem.

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Block copolymer-based self-assembled micellar nanocarriers exhibiting glutathione-responsive enhanced release of encapsulated drugs have been considered as promising candidates for tumortargeting drug delivery applications. Herein, we report a novel rosin-based block copolymer designed to self-assemble toward micellar nanocarriers positioned with disulfides at interfaces of hydrophobic rosin cores and hydrophilic poly(ethylene glycol) (PEG) coronas. The rosin-based micellar nanocarriers exhibit excellent colloidal stability in pseudo-physiological conditions and in the presence of proteins. Further, they enable the delivery of anticancer drugs to cancerous tissues for the enhanced release of encapsulated drugs through the destabilization of micelles with loosened structures of cores as a consequence of reduction-responsive shedding PEG coronas from rosin-based cores in response to glutathione. The results obtained from in vitro cell culture experiments including cell viability and cellular uptake suggest that reduction-responsive detachment of coronas promotes the inhibition of cell proliferation after internalization into cancer cells. These results suggest that the current design of rosin-based block copolymers and their assembled nanostructures with reduction-responsive sheddable coronas offer great versatility as intracellular drug-delivery nanocarriers for cancer therapy.

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“…Further to quantify the interaction of Cat-MDBC/USNPs with IgG, bicinchoninic acid (BCA) assay was used. 48 As seen in Figure 4d, 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 their relaxometric properties were determined at clinical magnetic field strengths (1.41 T, corresponding to 60 MHz). Longitudinal and transverse magnetic relaxation times (T 1 and T 2 respectively) were measured on dilutions of the colloids (Figure 5).…”

Section: Hela Cell Hek Cellmentioning

confidence: 99%

Mussel-Inspired Multidentate Block Copolymer to Stabilize Ultrasmall Superparamagnetic Fe₃O₄ for Magnetic Resonance Imaging Contrast Enhancement and Excellent Colloidal Stability

Chevallier

Ramrup

et al. 2015

Chem. Mater.

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Colloidal ultrasmall superparamagnetic iron oxide nanoparticles (USNPs) with better control of their surface chemistry have been considered as a biocompatible alternative to clinically-used gadolinium-based contrast agents for in vivo bright magnetic resonance imaging (MRI). Herein, we report a versatile mussel-inspired multidentate block copolymer strategy that allows for the stabilization of USNPs as promising MRI contrast agents with excellent colloidal stability. Wellcontrolled multidentate block copolymer with pendant multiple catechol groups (Cat-MDBC) is synthesized by a combination of controlled radical polymerization and post-modification methods. The Cat-MDBC proves to be effective to strongly anchor to USNP surfaces as well as provide optimal hydrophilic surfaces; thus, enabling the fabrication of aqueous Cat-MDBC/USNP colloids at single layers with diameter ≈20 nm through biphasic ligand exchange process. They exhibit excellent colloidal stability in broad pH range and physiological conditions; no significant protein adsorption; and great magnetic properties including relaxivity and in vitro MRI. Further comparison of Cat-MDBC with its corresponding catechol-based multidentate random copolymer suggests the importance of the architecture of multidentate polymeric ligands for USNP-based MRI diagnosis. P(OEOMA-co-tBMA) with DP = 25 for OEOMA units and DP = 31 for tBMA units and 2) hydrolytic cleavage of pendant t-butoxy groups of tBMA units to the corresponding P(OEOMAco-MAA) (i.e. COOH-MDRC). Next, similar to Cat-MDBC, well-controlled Cat-MDRC was synthesized by the carbodiimide-medicated coupling reaction of pendant COOH groups of COOH-MDRC with amino groups of dopamine. 1 H-NMR of the resultant Cat-MDRC shows the presence of pendant catechol groups at 6.3-6.7 ppm (e), pendant OEO moieties at 4.0 ppm (b) and 3.2-3.7 ppm, backbone methyl groups at 0.7-1.1 ppm (c, d), and terminal phenyl groups at 7.3 ppm (a). Similar to Cat-MDBC, the integral ratio of the peaks (b, c, d, and e) was used to determine the extent of coupling reaction to be >90% (Figure S10b). After the successful synthesis of Cat-MDRC, the similar procedure for biphasic ligand exchange was examined in aqueous solution at the mass ratio of Cat-MDRC/USNP = 5/1 wt/wt. Both DLS and TEM results suggest the formation of multimodal clusters of Cat-MDRC/USNP colloids with their average diameters to be 40 and 115 nm (Figure 6b and 6c). Further to see if the formation of large clusters is due to biphasic ligand exchange process, the conventional ligand exchange process was examined, where OA surface ligands were replaced with new Cat-MDRC ligands on USNPs in organic solution (chloroform/EtOH solvent mixture). The resulting Cat-MDBC/USNP colloids were dispersed in water, yielding clusters with the diameter to be 42.6 nm and large aggregates (diameter >1 µm) in aqueous solution (Figure S11 of DLS diagram). These results are different from the formation of single layered Cat-MDBC/USNP

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Intracellular delivery cellulose-based bionanogels with dual temperature/pH-response for cancer therapy

Cited by 40 publications

References 60 publications

Cellulose-Based Hydrogels as Sustained Drug-Delivery Systems

Cellulose-Based Hydrogels as Sustained Drug-Delivery Systems

Rosin-based block copolymer intracellular delivery nanocarriers with reduction-responsive sheddable coronas for cancer therapy

Mussel-Inspired Multidentate Block Copolymer to Stabilize Ultrasmall Superparamagnetic Fe₃O₄ for Magnetic Resonance Imaging Contrast Enhancement and Excellent Colloidal Stability

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Intracellular delivery cellulose-based bionanogels with dual temperature/pH-response for cancer therapy

Cited by 40 publications

References 60 publications

Cellulose-Based Hydrogels as Sustained Drug-Delivery Systems

Cellulose-Based Hydrogels as Sustained Drug-Delivery Systems

Rosin-based block copolymer intracellular delivery nanocarriers with reduction-responsive sheddable coronas for cancer therapy

Mussel-Inspired Multidentate Block Copolymer to Stabilize Ultrasmall Superparamagnetic Fe3O4 for Magnetic Resonance Imaging Contrast Enhancement and Excellent Colloidal Stability

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Mussel-Inspired Multidentate Block Copolymer to Stabilize Ultrasmall Superparamagnetic Fe₃O₄ for Magnetic Resonance Imaging Contrast Enhancement and Excellent Colloidal Stability