Intracellular enzymatic histochemistry of the human stomach with special reference to atrophic gastritis.

Ragins, Herzl; Dittbrenner, M.

doi:10.1136/gut.6.4.357

Cited by 26 publications

(3 citation statements)

References 15 publications

(18 reference statements)

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“…In atrophic gastritis, the chief cells are of course reduced in number, but the individual cases retain a normal AcP activity. The same finding was reported by R agins and D ittbrenner [17], and R oseman et al [18], For the other enzymes we found a diminution of activity in the majority of our cases of atrophic gastritis. We have been unable to detect any differ ence in the enzyme pattern of atrophic gastritis, with or without carcinoma.…”

Section: Histochemica! Characteristics O F Atrophic and Hypertrophic supporting

confidence: 79%

Gastroscopic and Histochemical Study of Normal, Atrophic and Hypertrophic Mucosa

Stoffels¹,

Desneux²,

Gepts³

1972

Digestion

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The correlation between gastroscopic and histological findings was studied in atrophic and hypertrophic gastritis. The histochemical characteristics of these forms of gastritis were determined. 65 stomachs were studied: 15 cases of normal stomach, 40 cases of atrophic gastritis, and 10 cases of hypertrophic gastritis. The biopsy material was obtained in 33 cases by a Crosby capsule, in 5 cases by a Storz biopsy gastroscope, and in 27 cases by laparotomy. The following enzymes were researched: SDH; BDH; LDH; ICDH; G-6-PD; α-GPD; ATPase; Estα; AlkP; AcP. The correlation between gastroscopical observations and histology was excellent, in the cases of atrophic gastritis and of normal stomach, but not in hypertrophic gastritis where in no cases the gastroscopical diagnosis was confirmed by histology. This may be due, as suggested by Schindler, to the type of prelevement (Crosby capsule and biopsy gastroscope). The histoenzymatic study of atrophic gastritis shows: (1) A decrease, in the parietal cells, of the enzymatic activity of several enzymes in 82% of the cases. This decrease was roughly parallel to the intensity of the atrophic changes, and was not equal in the same stomach, and among the different cases. This might be due to the variability of the noxa playing a role in the genesis of gastritis. The reduction, in the parietal cells, of the activity of such enzymes as SDH, ATPase, IDH, and G-6-PD suggests that the lowering of acid output observed in atrophic gastritis may also be due to a lowering of the activity of enzymes playing a part in the energy producing metabolism. (2) The superficial epithelial cells show a decreased enzymatic activity in 65% of the cases. This reduction was also proportional to the importance of the atrophy. The metabolic activity of these cells is probably lessened and, therefore, the mucosa defends itself less firmly. (3) Intestinal metaplasia was found in 50% of the cases. The enzymatic characteristics of intestinal metaplasia were not homogenous, marked differences were observed among individual cases, in the location and the intensity of enzymatic activity. Thus intestinal metaplasia does not appear as an homogenous change. The intestinal metaplasia predisposition to carcinoma is discussed. (4) There was no difference between the enzymatic activity of the chief cells in atrophic gastritis, compared with normal stomach. (5) The enzymatic activity in hypertrophic gastritis was identical to the normal stomach.

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Section: Histochemica! Characteristics O F Atrophic and Hypertrophic supporting

confidence: 79%

Gastroscopic and Histochemical Study of Normal, Atrophic and Hypertrophic Mucosa

Stoffels¹,

Desneux²,

Gepts³

1972

Digestion

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“…In addition to the brush border region they possess all other character istics of small intestine mucosa [4,12]. On the basis of histochemical enzyme determ inations the identity of the intestinalized gastric mucosa with normal small intestine mucosa had already been assumed [9]. Similar physiological qualities were recently dem onstrated by instillation of lipids into the stomach.…”

Section: Discussionmentioning

confidence: 66%

Disaccharidases of the Gastric Mucosa in Chronic Atrophic Gastritis with Intestinal Metaplasia

1968

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“…Ragins and Dittbrenner (1965) found moderate to severe gastritis in biopsies of the body mucosa in 53 % of a group of normal patients whose average age was 59 and age correlated well with the severity of the gastritis. Similar changes are present in the antral mucosa of duodenal ulcer patients, especially in older patients and in those with a long history of ulcer (Dean and Mason, 1965).…”

Section: Discussionmentioning

confidence: 88%

Late results of antrectomy and vagotomy.

Dean¹,

Edwards²,

Munro³

1966

Gut

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Intracellular enzymatic histochemistry of the human stomach with special reference to atrophic gastritis.

Cited by 26 publications

References 15 publications

Gastroscopic and Histochemical Study of Normal, Atrophic and Hypertrophic Mucosa

Gastroscopic and Histochemical Study of Normal, Atrophic and Hypertrophic Mucosa

Disaccharidases of the Gastric Mucosa in Chronic Atrophic Gastritis with Intestinal Metaplasia

Late results of antrectomy and vagotomy.

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