2022
DOI: 10.3390/molecules27196557
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Intracellular Enzyme-Instructed Self-Assembly of Peptides (IEISAP) for Biomedical Applications

Abstract: Despite the remarkable significance and encouraging breakthroughs of intracellular enzyme-instructed self-assembly of peptides (IEISAP) in disease diagnosis and treatment, a comprehensive review that focuses on this topic is still desirable. In this article, we carefully review the advances in the applications of IEISAP, including the development of various bioimaging techniques, such as fluorescence imaging, photoacoustic imaging, magnetic resonance imaging, positron-emission tomography imaging, radiation ima… Show more

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Cited by 8 publications
(3 citation statements)
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“…There are many reports showing peptide assembly forming nanofibers, nanotubes, nanobundles, and so on. [50][51][52] For the hydrogel of C 14 -FH(Trt)-OH, TEM imaging was done to first investigate formation of a self-assembled network (Fig. S6, ESI †).…”
Section: Hydrogel Morphologymentioning
confidence: 99%
“…There are many reports showing peptide assembly forming nanofibers, nanotubes, nanobundles, and so on. [50][51][52] For the hydrogel of C 14 -FH(Trt)-OH, TEM imaging was done to first investigate formation of a self-assembled network (Fig. S6, ESI †).…”
Section: Hydrogel Morphologymentioning
confidence: 99%
“…Especially, intracellularly instructed self-assembly of peptides have been considered as one of the most versatile strategies of developing novel biomaterials for disease treatment. 39 In general, peptide precursor includes three main modules: assembly module (photosensitizer or hydrophobic part), enzyme-responsive peptide sequence, and targeting peptide. They exist in the molecule form in blood circulation and can enter into tumor due to its small size.…”
Section: Covalently Triggered Peptide Self-assembly Designmentioning
confidence: 99%
“…Firstly, enzymes have played a crucial role in the assembly of complex peptide and oligonucleotide therapeutics, elevating the precision of drug design. [16][17][18][19] By selectively and efficiently catalyzing specific chemical reactions, enzymes enable pharmaceutical scientists to fine-tune the molecular structures of drugs, optimizing their efficacy and safety profiles. This newfound precision in drug synthesis carries profound implications, extending beyond the creation of novel therapeutic agents to encompass the optimization of existing medications.…”
Section: Introductionmentioning
confidence: 99%