Intracellular free calcium concentration and calcium transport in human erythrocytes of lead-exposed workers

Escorza, Martha Angélica Quintanar; González-Martı́nez, Marco T.; Navarro, L. T.; Maldonado, Mauricio; Arevalo, Bernardo; Calderón-Salinas, José-Víctor

doi:10.1016/j.taap.2006.10.016

Cited by 42 publications

(22 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Also, the appearance of sticking cells together in a chain like shape which are called Rouleaux appearance of RBCs. Those alterations were similar to these recorded due to apoptosis [29], after exposure to gavage dosing with 2-butoxyethanol [30], exposure to lead [31], and in Rett syndrome [32].…”

Section: Discussionsupporting

confidence: 75%

The protective role of green tea and garlic against the eryptosis induced by aging in albino rats

El‐Sokkary¹,

Alghriany²,

Atia³

2018

J Histol Histopathol

View full text Add to dashboard Cite

Objective: Green tea, is particularly rich in flavonoids, which are strong antioxidants. Also, garlic possesses both antioxidant and anti-inflammatory action in several oxidative stress conditions. Our aim was to evaluate the effects of aging as biological vital process on the eryptosis and erythrocytes alterations in albino rats and the ability of the green tea and garlic extract to alleviate those effects. Materials & methods: Four groups of both male and female rats [young (3 months-old), aged (26 months-old), aged+green tea (200 mg/kg) and aged+garlic (100 mg/kg)] were used. Blood smears prepared and stained by haematoxlyin and eosin for alteration in RBCs detection and acridine orange for eryptosis detection. Results: Blood smears showed that aging in males and females resulted in the appearance of pathologic types of RBCs as Tear drop like cells (Tr), Sickle cells (Sk), Amoeboid RBCs (Am), Target cells (Tg), Crenated cells (Cr), and Rouleaux appearance. Treatment with green tea decreased these alterations significantly in females while garlic decreased it significantly in both male and female groups. Moreover, eryptosis analyzed by Acridine orange stain showed increased number of eryptosis in RBCs in aging but decreased significantly by the treatment with both green tea and garlic in both genders. Conclusion: Administration of the green tea extract and garlic orally was able to reinstate the erythrocytes alterations and eryptotic level as biomarkers for the aging process evaluation and treatment

show abstract

Section: Discussionsupporting

confidence: 75%

The protective role of green tea and garlic against the eryptosis induced by aging in albino rats

El‐Sokkary¹,

Alghriany²,

Atia³

2018

J Histol Histopathol

View full text Add to dashboard Cite

show abstract

“…The metabolisms of calcium and lead are similar in certain respects and have a number of potential sites for interaction. It has been reported previously that Pb 2+ can be transported into the erythrocytes through the Ca 2+ transport systems and that this might alter calcium homeostasis [30].…”

Section: Resultsmentioning

confidence: 99%

Effects of chronic and acute lead treatments on the biophysical properties of erythrocyte membranes, and a comparison with model membranes

et al. 2013

View full text Add to dashboard Cite

Rat erythrocytes, or erythrocyte membrane ghosts, have been subjected to either chronic (drinking water containing 15 mM lead acetate for 3 months) or acute (10−9–10−2 M lead acetate for 1 h) Pb2+ treatments and subsequent changes in membrane properties have been measured. Pb2+ concentration in chronically treated rat plasma was 1.8 μM, which is one order of magnitude above normal values. Membrane permeability, or hemolysis, was increased in both cases. A comparative study using liposomes, in the form of large unilamellar vesicles, also indicated an increase in membrane permeability. Membrane microviscosity, or acyl chain molecular order, measured as DPH fluorescence polarization, showed an increased order in the acute treatments, at least below 700 μM Pb2+, and a similar increase in chronically treated rats. The correlation between acute and chronic treatments, and between cell and model membranes, suggests that the present observations may be relevant in the pathogenesis of lead intoxication in humans.

show abstract

“…The erythrocytes are responsible for the distribution and redistribution of lead throughout the body [31]. While blood flow through the other organs is fast as a result of the wider capillaries, the physical demands placed on the red cells are greatest in the spleen where the capillaries are the narrowest, thus resulting in slow blood flow through this organ.…”

Section: Discussionmentioning

confidence: 99%

Effects of sub-chronic low-level lead exposure on the homeostasis of copper and zinc in rat tissues

Ademuyiwa

Agarwal

Chandra

et al. 2010

Journal of Trace Elements in Medicine and Biology

View full text Add to dashboard Cite

Intracellular free calcium concentration and calcium transport in human erythrocytes of lead-exposed workers

Cited by 42 publications

References 34 publications

The protective role of green tea and garlic against the eryptosis induced by aging in albino rats

The protective role of green tea and garlic against the eryptosis induced by aging in albino rats

Effects of chronic and acute lead treatments on the biophysical properties of erythrocyte membranes, and a comparison with model membranes

Effects of sub-chronic low-level lead exposure on the homeostasis of copper and zinc in rat tissues

Contact Info

Product

Resources

About