Intracellular interaction and biotransformation of arsenite in rats and rabbits

Marafante, E.; Bertolero, Federico; Edel, J.; Pietra, R.; Sabbioni, E.

doi:10.1016/0048-9697(82)90055-9

Cited by 73 publications

(22 citation statements)

References 21 publications

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“…The data obtained in this study also favors this observation as there was highest accumulation of arsenic in the spleen followed by lung, liver, kidney, skin and lowest accumulation was in intestine. This finding is almost similar to others (Marafante, 1982). Accumulation of arsenic in lungs was also high which is particularly important because one of the principal causes of mortality in arsenicosis is due to lung cancer.…”

Section: Discussionsupporting

confidence: 78%

Effect of hexane extract of spinach in the removal of arsenic from rat

Umar

2008

Bangladesh J Pharmacol

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Section: Discussionsupporting

confidence: 78%

Effect of hexane extract of spinach in the removal of arsenic from rat

Umar

2008

Bangladesh J Pharmacol

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“…Arsenic loads detected in lung, liver, kidney and blood of which highest accumulation was found in blood of all treated groups and the arsenic concentration in liver was the lowest and kidney was the medium. The data obtained in this study were not in favor of Marafante et al (1982), who showed that the highest accumulation of arsenic in the spleen followed by lung, liver, kidney, skin and lowest accumulation was in intestine. The raised level in the blood is due to direct absorption of arsenic to the blood.…”

Section: Discussionmentioning

confidence: 68%

Protective Role of Spirulina and Vitamin E against Arsenic Toxicity in Rats

Gofur¹,

Sayed²,

Khair³

et al. 2015

Asian J. of Animal Sciences

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Arsenic is one of the most sensitive environmental issues in Bangladesh; even it is a major health concern in Asia. Spirulina and vitamin E have been considered as a potential therapeutic supplement due to its ability to minimize several element induced toxicities in various species including man. The study was performed to evaluate the role of spirulina (Spirulina platensis) and vitamin E in prevention of arsenic toxicity in different groups (T 0-4 , n = 60) of Long-Evans rats. T 0 was control group, T 1 was treated with sodium arsenite, T 2 was treated with sodium arsenite plus spirulina, T 3 was treated with sodium arsenite plus vitamin E and T 4 was treated with sodium arsenite plus vitamin E plus spirulina daily for 63 days. Sodium arsenite was at 4 mg kgG 1 b.wt., spirulina was at 1 g kgG 1 feed and vitamin E was at 200 mg kgG 1 feed. Samples were collected on day 21, 42 and 63. Arsenic was detected from tissue samples by Hydride Generation Atomic Absorption Spectrophotometer (HGAAS). Sodium arsenite feeding in rats caused chronic arsenic toxicity and the arsenic content in tissues (blood, lung, liver and kidney) of the exposed rats were significantly higher than control rats. Spirulina and vitamin E treatments significantly lowered the arsenic content in tissues. Arsenic caused hepatic and renal dysfunction but spirulina and vitamin E improved the hepatic and renal functions. Spirulina feeding was more effective than vitamin E and their combined treatment was more effective compare to their single treatment. The study demonstrates the role of spirulina and vitamin E in the reduction of toxicity of arsenic.

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“…Once in systemic circulation, arsenic is rapidly cleared from blood and distributed to all major organs in the body in most common laboratory animals, including mice, rabbits, and hamsters (Vahter and Norin, 1980;Marafante, Bertolero and Edel, 1982;Marafante, Vahter and Envall, 1985;Yamauchi and Yamamura, 1985;Kenyon, Del Razo and Hughes, 2005a;Kenyon, Del Razo and Hughes, 2005b). In humans, inorganic arsenic is also rapidly cleared from blood with a half-life of about two hours.…”

Section: Systemic Clearance Of Arsenic and Binding To Blood Componentsmentioning

confidence: 99%

“…Many of these studies have used radiolabeled arsenic and it is noteworthy that arsenic-derived radioactivity is generally present in all examined tissues (Marafante, Bertolero and Edel, 1982;Kenyon, Del Razo and Hughes, 2005a;Kenyon, Del Razo and Hughes, 2005b;Lindgren, Vahter and Dencker, 1982;Vahter et al, 1982;Vahter and Marafante, 1985).…”

Section: Tissue Distributionmentioning

confidence: 99%

“…However, the levels are uniformly low both across time and relative to other tissues, which indicate that arsenic does not readily cross the blood-brain barrier or accumulate in brain tissue following acute dosing (Marafante, Bertolero and Edel, 1982;Yamauchi and Yamamura, 1985;Lindgren, Vahter and Dencker, 1982;Dang, Jaiswal and Somasundaram, 1983;Yamauchi and Yamamura, 1983;Vahter et al, 1982;Vahter and Marafante, 1985).…”

Section: Tissue Distributionmentioning

confidence: 99%

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