Intracellular Liposomes and Cholesterol Deposits in Chronic Cholecystitis and Biliary Sludge

Gilloteaux, Jacques; Miller, Dylan V.; Rl, Morrison

doi:10.1080/01913120490475888

Cited by 7 publications

(13 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other cholesterol deposits can be fibrillar or curve-shaped accretions in lysosomes (Figs. 15,17) and resemble morphologically the intracellular types detected in cholecystitis (Kouroumalis et al, 1983b;Gilloteaux et al, 1997Gilloteaux et al, ,b, 2003Gilloteaux et al, , 2004 or cholesterolosis (Nevalainen and Laitio, 1972;Koga et al, 1975;Koga, 1985;Gilloteaux et al, 1997Gilloteaux et al, ,a, 2003Gilloteaux et al, , 2004Satoh and Koga, 1997). Some of those can reach more than 2 lm in diameter and are usually oblong in shape.…”

Section: Discussionmentioning

confidence: 99%

“…The lipid content, abundant to enormous aggregates of mitochondria, lysosomes, peroxisomes, and secretory mucous vesicles are coupled with a mucosal surface of pleiomorphic folds covered with microvilli and long, apical projections. Some lipid deposits contained cholesterol deposits similar to those described in human cholesterolosis (Nevalainen and Laitio, 1972;Koga et al, 1975;Koga, 1985;Gilloteaux et al, 1997,a) and in some forms of cholecystitis (Gilloteaux et al, ,b, 2003(Gilloteaux et al, , 2004.…”

mentioning

confidence: 82%

See 1 more Smart Citation

The Gallbladder ofUranoscopus ScaberL. (Teleost Perciform Fish) is Lined by Specialized Cholecystocytes

Gilloteaux

Ott

Oldham-Ott

2011

The Anatomical Record

View full text Add to dashboard Cite

The gallbladder of Uranoscopus exhibits a mucosal surface layer of simple columnar epithelium composed of specialized cholecystocytes. The apices show storage and mucous secretions, typical microvilli, and very apical projections extending deep into the luminal contents. Many organelles and heterogeneous vesicles of diverse size fill the cytoplasm, including neutral mucins, mitochondria, peroxisomes, lysosomal bodies, and lipid-rich deposits with cholesterol inclusions. The fibromuscular layer shows little blood supply and contains scattered lymph-like walls with minute cholesterol inclusions. The remaining muscular, subserosal, and serosal or adventitial layers of this species do not show any histologic differences to those of other Vertebrates. It was unexpected to find cholesterol inclusions in the fatty deposits of the cholecystocytes, similar to those noted in human cholesterolosis and in some forms of hypercholesterolemia, in this teleostean. In addition, aggregations of mitochondria and anomalous mitochondrial morphologies were found that resemble oncocytoma-like changes. Anat Rec, 294:1890Rec, 294: -1903Rec, 294: , 2011. V V C 2011 WileyLiss, Inc.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 82%

The Gallbladder ofUranoscopus ScaberL. (Teleost Perciform Fish) is Lined by Specialized Cholecystocytes

Gilloteaux

Ott

Oldham-Ott

2011

The Anatomical Record

View full text Add to dashboard Cite

show abstract

“…Thus, the authors have outlined support for the hypothesis that a prolonged, untreated cholecystitis could then cause malignant changes or cholesterolosis, as a basis for the clinical porcelain gallbladder [7].…”

mentioning

confidence: 90%

“…The cholecystocytes have altered microvilli, mitochondrial damages in the apical region, as well as mucous accumulation with aggregated, angulated lysosomes and liposomes with needleshaped crystals. Cell fragments were observed in the biliary sludge [7].…”

mentioning

confidence: 99%

See 1 more Smart Citation

Chronic Cholecystitis

Nesland

2004

Ultrastructural Pathology

View full text Add to dashboard Cite

The Gallbladder of the Electric Ray Torpedo Marmorata Risso Displays Excrescent Cholecystocytes with Merocrine and Apocrine‐Like Secretions

Gilloteaux

Ott

Oldham-Ott

2012

The Anatomical Record

View full text Add to dashboard Cite

The gallbladder of Torpedo marmorata exhibits a mucosal surface layer of simple columnar epithelium with very tall cholecystocytes. The apical domain of each cell has few microvilli, but many mucous vesicles that are secreted by exocytosis at the cell apices. The apical regions may also elongate and undergo self-excision while shedding mucus and cell debris into the gallbladder lumen in a manner similar to that described in mammals as a result of sex steroid treatment to induce gallstones and to that found in the cholecystitis associated with cholelithiasis. Numerous small mitochondria, spherical to elongated, are distributed throughout the cells, while the nuclei are often located in the lower third of each cell. In the lower part of the cholecystocytes, large and very densely contrasted lysosomes can be found. All cells are tightly joined by junctional complexes, including long, highly contrasted desmosomes. The fibromuscular layer is made of a loose stroma with a limited muscular component and a poor blood supply. Large diameter blood vessels can only be found in the subserosal layer. It is hypothesized that the obligatorily carnivorous diet of this ureotelic fish has resulted in the evolution of a gallbladder ultrastructure resembling that found in cholecystitis but without the associated cholelithiasis. Anat Rec,

show abstract

Intracellular Liposomes and Cholesterol Deposits in Chronic Cholecystitis and Biliary Sludge

Cited by 7 publications

References 57 publications

The Gallbladder ofUranoscopus ScaberL. (Teleost Perciform Fish) is Lined by Specialized Cholecystocytes

The Gallbladder ofUranoscopus ScaberL. (Teleost Perciform Fish) is Lined by Specialized Cholecystocytes

Chronic Cholecystitis

The Gallbladder of the Electric Ray Torpedo Marmorata Risso Displays Excrescent Cholecystocytes with Merocrine and Apocrine‐Like Secretions

Contact Info

Product

Resources

About