Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins

Rhee, Sue Goo; Kang, Sang Won; Jeong, Woojin; Chang, Tong Shin; Yang, Kap Seok; Woo, Hyun Ae

doi:10.1016/j.ceb.2005.02.004

Cited by 671 publications

(466 citation statements)

References 47 publications

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“…Repair of the sulfinyl group supports the concept that the Prx inactivation-reactivation cycle represents a cell signaling loop [50,[63][64][65][66] (Table 1). This notion is supported by recent studies that show that cell cycle arrest is associated with recruitment of hyper-oxidized PrxII to high molecular weight oligomers, and that recovery is correlated with regeneration of reduced enzyme [67].…”

Section: Control Of H 2 O 2 Tonesupporting

confidence: 58%

“…In this regard, both the NO and H 2 O 2 systems rely on the principle of Cys-based posttranslational modifications. It is therefore of some surprise that while many reviews on the topic of redox signaling have been published [1,3,31,50,51] most highlight either H 2 O 2 or NO selectively; co-existence of both oxidants and their respective chemical reactivities within the same cell is rarely considered.…”

Section: Relative Importance Of No-or H 2 O 2 -Dependent Cysteine Oximentioning

confidence: 99%

“…At least six mammalian Prx have been identified, subdivided into 2-Cys, atypical 2-Cys, and 1-Cys Prx, which exist as homodimers in different subcellular compartments ( [50] for review). Prx are highly abundant and are believed to control the H 2 O 2 tone.…”

Section: Control Of H 2 O 2 Tonementioning

confidence: 99%

“…Prx are highly abundant and are believed to control the H 2 O 2 tone. Their over-expression lowers intracellular levels of H 2 O 2 , and leads to inhibition of signaling induced by PDGF, TNFα, or ceramide, suggesting that Prx enzymes contribute to signaling by removing H 2 O 2 [3,50].…”

Section: Control Of H 2 O 2 Tonementioning

confidence: 99%

See 3 more Smart Citations

Redox-based regulation of signal transduction: Principles, pitfalls, and promises

Janssen–Heininger¹,

Mossman²,

Heintz³

et al. 2008

Free Radical Biology and Medicine

Self Cite

705

652

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Section: Control Of H 2 O 2 Tonesupporting

confidence: 58%

Section: Relative Importance Of No-or H 2 O 2 -Dependent Cysteine Oximentioning

confidence: 99%

Section: Control Of H 2 O 2 Tonementioning

confidence: 99%

Section: Control Of H 2 O 2 Tonementioning

confidence: 99%

See 2 more Smart Citations

Redox-based regulation of signal transduction: Principles, pitfalls, and promises

Janssen–Heininger¹,

Mossman²,

Heintz³

et al. 2008

Free Radical Biology and Medicine

Self Cite

705

652

View full text Add to dashboard Cite

“…In this hypothesis, the inactivation of 2-cys-Prdx by overoxidation of an active site cysteine to a sulfinic acid would allow H 2 O 2 to react with signaling proteins Although the reduction of the sulfinic acid form has been demonstrated to be catalyzed by sulfiredoxin (Srx) (29), in most systems, 2-cys-Prdx is not the rate-limiting enzyme for removal of H 2 O 2 so that its inhibition would not provide a flood of H 2 O 2 . Also, the rate of formation of the sulfinic acid, which is second order in [H 2 O 2 ], would need to out-compete reactions of H 2 O 2 with target signaling proteins.…”

Section: <6>mentioning

confidence: 99%

The chemistry of cell signaling by reactive oxygen and nitrogen species and 4-hydroxynonenal

Forman

Fukuto

Miller

et al. 2008

Archives of Biochemistry and Biophysics

219

165

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During the past several years, major advances have been made in understanding how reactive oxygen species (ROS) and nitrogen species (RNS) participate in signal transduction. Identification of the specific targets and the chemical reactions involved still remains to be resolved with many of the signaling pathways in which the involvement of reactive species has been determined. Our understanding is that ROS and RNS have second messenger roles. While cysteine residues in the thiolate (ionized) form found in several classes of signaling proteins can be specific targets for reaction with H 2 O 2 and RNS, better understanding of the chemistry, particularly kinetics, suggests that for many signaling events in which ROS and RNS participate, enzymatic catalysis is more likely to be involved than non-enzymatic reaction. Due to increased interest in how oxidation products, particularly lipid peroxidation products, also are involved with signaling, a review of signaling by 4-hydroxy-2-nonenal (HNE) is included. This article focuses on the chemistry of signaling by ROS, RNS, and HNE and will describe reactions with selected target proteins as representatives of the mechanisms rather attempt to comprehensively review the many signaling pathways in which the reactive species are involved. Keywords signaling; glutathione; thioredoxin; oxidants; reactive oxygen species; thiols; peroxide; nitric oxide; peroxynitrite; 4-hydroxynonenal; cysteine; hydrogen peroxide; protein tyrosine phosphatase; reactive nitrogen species; eNOS; iNOS; nNOS; soluble guanylate cyclase; cGMP; tyrosine nitration; fatty acid nitration; NO-heme; NO-metal complexes; nitrite; protein kinase C; ERK; JNK; p38MAPK; tyrosine kinase receptors; calcium OVERVIEW OF SIGNALING BY REACTIVE SPECIESUnderstanding of the roles of reactive oxygen species (ROS), reactive nitrogen species (RNS) and the lipid peroxidation product, 4-hydroxy-2-nonenal (HNE) in signaling has evolved rapidly during the last decade. This has been markedly helped by identification of the specific targets in signaling pathways. In previous reviews, we defined how ROS, H 2 O 2 in particular,

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GSH, Sulfur Amino Acids, and Apoptosis

Filomeni

Aquilano

Ciriolo

2008

Glutathione and Sulfur Amino Acids in Human Health and Disease

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Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins

Cited by 671 publications

References 47 publications

Redox-based regulation of signal transduction: Principles, pitfalls, and promises

Redox-based regulation of signal transduction: Principles, pitfalls, and promises

The chemistry of cell signaling by reactive oxygen and nitrogen species and 4-hydroxynonenal

GSH, Sulfur Amino Acids, and Apoptosis

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