Intracellular trafficking of prohormones and proneuropeptides: cell type‐specific sorting and targeting

Perone, Marcelo J.; Windeatt, S.; Castro, María G.

doi:10.1113/expphysiol.1997.sp004051

Cited by 6 publications

(3 citation statements)

References 72 publications

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“…The complexity of the actual neuropeptidergic signalling is (fortunately) somewhat reduced by the fact that all of the neuropeptides synthesized by a neuron are usually copackaged into the same exocytotic vesicles and coreleased. Selective sorting of the neuropeptides for selective release from different processes of the same neuron is known, however (Sossin & Scheller 1991;Perone et al 1997). Furthermore, different neurons release different complements of the neuropeptides, thanks to such mechanisms as alternative splicing of the neuropeptide mRNAs (Buck et al 1987;Benjamin & Burke 1994;Perone et al 1997) and, of course, the transcription of different subsets of the neuropeptide genes.…”

Section: Multiplicity Of Neuromodulatorsmentioning

confidence: 99%

“…Selective sorting of the neuropeptides for selective release from different processes of the same neuron is known, however (Sossin & Scheller 1991;Perone et al 1997). Furthermore, different neurons release different complements of the neuropeptides, thanks to such mechanisms as alternative splicing of the neuropeptide mRNAs (Buck et al 1987;Benjamin & Burke 1994;Perone et al 1997) and, of course, the transcription of different subsets of the neuropeptide genes. It is now clear that very many neurons-in some nervous systems, seemingly all neurons-release some complement of neuropeptides as cotransmitters alongside their 'primary' classical transmitter (Kupfermann 1991;Maggi 1995;Lundberg 1996;Hö kfelt et al 2000;Merighi 2002).…”

Section: Multiplicity Of Neuromodulatorsmentioning

confidence: 99%

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Beyond the wiring diagram: signalling through complex neuromodulator networks

Březina

2010

Phil. Trans. R. Soc. B

112

108

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During the computations performed by the nervous system, its 'wiring diagram'-the map of its neurons and synaptic connections-is dynamically modified and supplemented by multiple actions of neuromodulators that can be so complex that they can be thought of as constituting a biochemical network that combines with the neuronal network to perform the computation. Thus, the neuronal wiring diagram alone is not sufficient to specify, and permit us to understand, the computation that underlies behaviour. Here I review how such modulatory networks operate, the problems that their existence poses for the experimental study and conceptual understanding of the computations performed by the nervous system, and how these problems may perhaps be solved and the computations understood by considering the structural and functional 'logic' of the modulatory networks.

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Section: Multiplicity Of Neuromodulatorsmentioning

confidence: 99%

Section: Multiplicity Of Neuromodulatorsmentioning

confidence: 99%

Beyond the wiring diagram: signalling through complex neuromodulator networks

Březina

2010

Phil. Trans. R. Soc. B

112

108

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“…Further maturation of the peptides may occur in the dense core vesicles before they are released in response to specific stimuli. The sorting and packaging of neuropeptides are the subject of many investigations (e.g., Sossin and Scheller, 1991;Klumperman et al, 1996;Perone et al, 1998;Arvan and Castle, 1998;Canaff et al, 1999;Dannies, 1999;Tooze et al, 2001). Different neuropeptides, which are expressed in a neuron at a certain time, can be found together in a single mature vesicle type.…”

mentioning

confidence: 99%

Differential sorting and packaging of capa-gene related products in an insect

et al. 2004

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A unique costorage of neuropeptides was recently found in the abdominal perisympathetic organs (PSOs) of the American cockroach, Periplaneta americana. Having specific antisera directed against all peptides belonging to this neurosecretory system, we examined the sorting of PSO-peptides in the soma of the median neurosecretory cells of abdominal ganglia by using immunoelectron microscopic double stainings. The data indicate that all six abundant neuropeptides of this neurohormonal system, which includes three capa-gene related products, are primarily incorporated into separate vesicles. These vesicles fuse with each other in the cytoplasm and become translucent on their way to the axon hillock. By means of light microscopy and MALDI-TOF mass spectrometry, an identical population of neuropeptides was found in interneurons of the brain. As revealed by subsequent immunoelectron microscopic analysis, the peptides of these cells are separately packed into dense core vesicles but do not fuse with each other. Thus, hitherto unknown cell-type-specific sorting mechanisms occur in neurosecretory cells and interneurons, respectively.

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