2017
DOI: 10.1021/acs.bioconjchem.7b00658
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Intracellularly Actuated Quantum Dot–Peptide–Doxorubicin Nanobioconjugates for Controlled Drug Delivery via the Endocytic Pathway

Abstract: Nanoparticle (NP)-mediated drug delivery (NMDD) has emerged as a novel method to overcome the limitations of traditional systemic delivery of therapeutics, including the controlled release of the NP-associated drug cargo. Currently, our most advanced understanding of how to control NP-associated cargos is in the context of soft nanoparticles (e.g., liposomes), but less is known about controlling the release of cargos from the surface of hard NPs (e.g., gold NPs). Here we employ a semiconductor quantum dot (QD)… Show more

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Cited by 47 publications
(39 citation statements)
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“…It is also worth noting that over the four days of the experimental time course, the cells remained healthy and functional, consistent with our previous work that showed minimal impact on viability when cells are simultaneously transfected with plasmid DNA and interfaced with QDs at various cellular locations. [29,23,24,26,27]…”
Section: Resultsmentioning
confidence: 99%
“…It is also worth noting that over the four days of the experimental time course, the cells remained healthy and functional, consistent with our previous work that showed minimal impact on viability when cells are simultaneously transfected with plasmid DNA and interfaced with QDs at various cellular locations. [29,23,24,26,27]…”
Section: Resultsmentioning
confidence: 99%
“…Furthermore, electrochemical DNA sensors offer a faster, more specific, sensitive, and versatile detection modality for target pathogen molecules [137]. Moreover, nanocarriers can bind to commonly used drugs such as doxorubicin to reduce side effects, toxicity, and drug resistance in cancer therapy [138][139][140][141]. Nanorobots can be used to carry thrombin and stop blood flow in tumor vessels, while DNA-based signal amplification methods combined with DNA-integrated gold nanomaterials accurately detect tumor biomarkers [138].…”
Section: Current Dna-based Approaches Being Developed Towards Diagnosismentioning
confidence: 99%
“…They efficiently allow for multidrug or combinational therapy targeting (Wang et al 2016;Costa-Gouveia et al 2017;Zhang et al 2017;Yan et al 2018) achieving synergistic, or multi-targeting, or theranostic applications. Functionalized NPs can deliver the active substance intracellularly (Medina et al 2009Sangtani et al 2018. Furthermore, NPs could be modulated with mechanisms to target only the diseased tissue or cells, either passively, through the enhanced permeability and retention effect (EPR) (increased local blood supply tends to pool the NPs as in case of tumor sites), or actively, through targeting molecules like antibodies (here the tumor cells selectively intake the NPs) (Zimmer 2002;Zamboni et al 2012).…”
Section: Introductionmentioning
confidence: 99%