1987
DOI: 10.1001/archneur.1987.00520200052018
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Intracerebral Hemorrhage After Experimental Embolic Infarction

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Cited by 35 publications
(22 citation statements)
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“…17,18,21,22,25 We found that TLT could be administered safely either alone or in the presence of tPA because neither the monotherapy nor combination therapy affected hemorrhage rate compared with their respective controls. Treatments also did not alter hemorrhage volume compared with the embolized control group.…”
Section: Discussionmentioning
confidence: 80%
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“…17,18,21,22,25 We found that TLT could be administered safely either alone or in the presence of tPA because neither the monotherapy nor combination therapy affected hemorrhage rate compared with their respective controls. Treatments also did not alter hemorrhage volume compared with the embolized control group.…”
Section: Discussionmentioning
confidence: 80%
“…To evaluate the safety profile of the combination therapy, we used the rabbit large clot embolic stroke model, an animal model of middle cerebral artery occlusion [17][18][19][20][21] that is sensitive to intravenously administered tPA resulting in a significantly increased rate of hemorrhage. 18 -25 To address the effects of TLT on both thrombolytic-induced hemorrhage rate and on hemorrhage volume, we adopted a design in which the thrombolytic would be administered 60 minutes after embolization and then TLT would be applied subsequent to thrombolytic treatment.…”
mentioning
confidence: 99%
“…Previous experimental work using animal models of stroke has similarly suggested that anticoagulant therapy promotes brain hemorrhage, 1819 although one more recent study reported no increase in brain hemorrhage in animals acutely treated with therapeutic or excessive doses of heparin. 20 In the only randomized clinical trial of anticoagulant therapy for acute cardioembolic stroke to date, the Cerebral Embolism Study Group 16 reported no significant hemorrhagic complications and a trend toward reduction of recurrent embolization in their treated patients. Unfortunately, that study was terminated before statistically significant evidence of benefit from early anticoagulant therapy could be established.…”
Section: Discussionmentioning
confidence: 99%
“…We have found this to be a sensitive and reproducible method of quantifying cerebral hemorrhage. 56 ' 20 This technique identifies visible cerebral hemorrhage but does not differentiate between intracerebral hematomas and hemorrhagic infarction.…”
mentioning
confidence: 99%
“…These hemorrhage incidence results are similar to our previous study, which also did not detect an increased incidence of hemorrhage using various heparin doses in this model (an approximate 37% hemorrhage rate). 20 Caution is needed when generalizing the results from young, previously healthy, ischemic animals to the clinical situation. However, the combined results from our two heparin experimental embolic stroke studies, representing 69 heparin-treated animals, did not show an increased cerebral hemorrhage rate or size with heparin anticoagulation, even when used concurrently with t-PA thrombolysis.…”
mentioning
confidence: 99%