Intracerebral mass lesions in patients with human immunodeficiency virus infection and cryptococcal meningitis

Sánchez-Portocarrero, J; Pérez–Cecilia, Elisa

doi:10.1016/s0732-8893(97)81809-3

Cited by 17 publications

(12 citation statements)

References 23 publications

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“…Central nervous system cryptococcosis is a particularly important neurological problem in humans with acquired immunodeficiency syndrome (AIDS). There are numerous reports of MRI findings in humans with intracranial cryptococcosis but mostly with respect to patients with AIDS (Tien et al 1991, Mathews et al 1992, Andreula et al 1993, Miszkiel et al 1996, Sánchez-Portocarrero & Pérez-Cecilia 1997. Magnetic resonance imaging in humans with intracranial cryptococcosis usually demonstrates meningitis or meningoencephalitis, dilated Virchow-Robin spaces, cyst-like structures (gelatinous pseudocysts) and granulomas (cryptococcomas) (Andreula et al 1993, Ostrow & Hudgins 1994, Miszkiel et al 1996.…”

Section: Discussionmentioning

confidence: 99%

Cerebral Cryptococcal Granuloma in a Cat

Foster

Charles

Parker³

et al. 2000

Journal of Feline Medicine and Surgery

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A 7-year-old cat was presented for seizures. Cerebrospinal fluid cytology and serology were consistent with a diagnosis of toxoplasmosis. The cat was treated with clindamycin but seizures continued and additional neurological signs developed over 6 months. A mass lesion was identified in the left cerebral hemisphere using magnetic resonance imaging (MRI). The lesion enhanced after gadolidium and a tumour was considered likely. Histologically, the lesion proved to be a cryptococcal granuloma and retrospective serology confirmed that the cat had cryptococcosis at its initial presentation. This report provides the first description in the veterinary literature of the MRI appearance of a cerebral cryptococcoma and emphasises the importance of performing cryptococcal antigen determination in cats with signs of intracranial disease.

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Section: Discussionmentioning

confidence: 99%

Cerebral Cryptococcal Granuloma in a Cat

Foster

Charles

Parker³

et al. 2000

Journal of Feline Medicine and Surgery

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“…Although CNS lesions detectable on neuroimaging studies occur less commonly (10–18), they are a significant complication of cryptococcal disease and were independently associated with lower survival in one study (8). CNS lesions due to cryptococcosis in SOT recipients have largely been reported as case reports or case series comprising a small number of patients (1, 2, 19).…”

Section: Introductionmentioning

confidence: 94%

Central Nervous System Cryptococcosis in Solid Organ Transplant Recipients: Clinical Relevance of Abnormal Neuroimaging Findings

et al. 2008

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Background Prognostic implications of cryptococcal antigen and outcomes associated with CNS cryptococcal lesions in solid organ transplant (SOT) recipients have not been fully defined. Methods Patients were derived form a cohort of 122 SOT recipients with cryptococcosis in a multicenter study from 1999–2006. Results CNS cryptococcosis was documented in 61 patients. Serum or CSF antigen titers did not correlate with mortality at 90 days or CSF sterilization at 2 weeks. CNS lesions were identified in 16 patients and included leptomeningeal lesions in 8, parenchymal lesions in 6 and hydrocephalus in 2. Overall, 13/16 CNS lesions were present at the time of diagnosis. One parenchymal and 2 hydrocephalus lesions however, developed after diagnosis and fulfilled the criteria for immune reconstitution syndrome (IRS). CSF antigen titers were higher with meningeal vs. parenchymal lesions, and hydrocephalus (p=0.015). Mortality was 50% (3/6) for patients with parenchymal, 12.5% (1/8) for those with leptomeningeal, and 0/3 for patients with hydrocephalus. Mortality was 31% (4/13) for patients with CNS lesions at baseline and 0/3 in those with new onset lesions. Conclusions Despite a greater antigen titer with meningeal lesions, outcomes tended to be worse with parenchymal compared to meningeal lesions or hydrocephalus. New onset CNS lesions may represent IRS and appeared to be associated with better outcome.

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“…Cryptococcal meningitis is the most common manifestation of systemic fungal infection and the third most frequent neurological complication in patients with AIDS (Leenders et al 1994;Sanchez-Portocarrero & Perez-Cecilia 1997;Oursler et al 1999). 5-10% of HIV-infected patients will develop it as an AIDS defi ning illness (Fessler et al 1998).…”

Section: Epidemiologymentioning

confidence: 99%

Human immunodeficiency virus associated central nervous system infections

Török

2005

Pract Neurol

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Intracerebral mass lesions in patients with human immunodeficiency virus infection and cryptococcal meningitis

Cited by 17 publications

References 23 publications

Cerebral Cryptococcal Granuloma in a Cat

Cerebral Cryptococcal Granuloma in a Cat

Central Nervous System Cryptococcosis in Solid Organ Transplant Recipients: Clinical Relevance of Abnormal Neuroimaging Findings

Human immunodeficiency virus associated central nervous system infections

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