Intracerebroventricular injection of L-arginine and D-arginine induces different effects under an acute stressful condition

Tran, Phuong V.; Nguyen, Linh T.; Yang, Hui; Phong, H.; Torii, K.; Putnam, Grace L.; Chowdhury, Vishwajit S.; Furuse, Mitsuhiro

doi:10.1016/j.bbrc.2020.09.111

Cited by 4 publications

(1 citation statement)

References 26 publications

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“…Put, spermidine (Spd), and spermine (Spm), as components of polyamine metabolic pathway, are the most common diamine and polyamines in seed plants [6]. D-arginine is Genes 2022, 13, 784 2 of 13 used as the specific inhibitor of ADC [7,8]. Arginine was catalyzed to agmatine by ADC, and agmatine iminohydrolase catalyzed agmatine to N-carbamoylputrescine, which was then catalyzed by N-carbamoylputrescine amidohydrolase, then Put is produced [9].…”

Section: Introductionmentioning

confidence: 99%

Arginine Decarboxylase Gene ADC2 Regulates Fiber Elongation in Cotton

Ren

2022

Genes

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Cotton is an important agro-industrial crop providing raw material for the textile industry. Fiber length is the key factor that directly affects fiber quality. ADC, arginine decarboxylase, is the key rate-limiting enzyme in the polyamine synthesis pathway; whereas, there is no experimental evidence that ADC is involved in fiber development in cotton yet. Our transcriptome analysis of the fiber initiation material of Gossypium arboreum L. showed that the expression profile of GaADC2 was induced significantly. Here, GhADC2, the allele of GaADC2 in tetraploid upland cotton Gossypium hirsutum L., exhibited up-regulated expression pattern during fiber elongation in cotton. Levels of polyamine are correlated with fiber elongation; especially, the amount of putrescine regulated by ADC was increased. Scanning electron microscopy showed that the fiber length was increased with exogenous addition of an ADC substrate or product putrescine; whereas, the fiber density was decreased with exogenous addition of an ADC specific inhibitor. Next, genome-wide transcriptome profiling of fiber elongation with exogenous putrescine addition was performed to determine the molecular basis in Gossypium hirsutum. A total of 3163 differentially expressed genes were detected, which mainly participated in phenylpropanoid biosynthesis, fatty acid elongation, and sesquiterpenoid and triterpenoid biosynthesis pathways. Genes encoding transcription factors MYB109, WRKY1, and TCP14 were enriched. Therefore, these results suggested the ADC2 and putrescine involvement in the development and fiber elongation of G. hirsutum, and provides a basis for cotton fiber development research in future.

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Section: Introductionmentioning

confidence: 99%

Arginine Decarboxylase Gene ADC2 Regulates Fiber Elongation in Cotton

Ren

2022

Genes

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Raw Pinelliae Rhizoma: examination of sedative and hypnotic effects in mice and chemical analysis

et al. 2022

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Effect of <dfn>Orostachys spinosa </dfn> dry extract on white rat behavior in tests with positive reinforcement

Razuvaeva¹

2023

Psychopharmacology & biological narcology

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The purpose of the study to determine the Orostachys spinosa dry extract effect on the white rats behavior in tests with positive reinforcement. Materials and methods. The experiments were carried out on Wistar rats. The O. spinosa dry extract effect at doses of 50, 100, and 200 mg/kg on animal behavior was assessed in the hypophagy and T-maze tests. Results. Against the background of the O. spinosa extract introductionat doses of 100 and 200 mg/kg, the number of animals fed in the hypophagy test was 1.6 and 1.8 times greater than in the control; the feed volume exceeded by 94 and 78%, respectively, the indicator in control group animals. On the 4th day of training, a conditioned reflex was formed in 100% of the animals treated with O. spinosa extract at a dose of 200 mg/kg. Against the background of the O. spinosa extract introduction at a dose of 100 mg/kg and the reference drug, a conditioned reflex was formed in 63 and 71% of the animals, respectively, which is 2.0 times higher than in the control. Conclusions. The O. spinosa dry extract in doses of 100 and 200 mg/kg has a positive effect on the removal of the anxiety level, promotes an increase in orienting-exploratory activity, and thereby accelerates a conditioned reflex development in white rats.

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Intracerebroventricular injection of L-arginine and D-arginine induces different effects under an acute stressful condition

Cited by 4 publications

References 26 publications

Arginine Decarboxylase Gene ADC2 Regulates Fiber Elongation in Cotton

Arginine Decarboxylase Gene ADC2 Regulates Fiber Elongation in Cotton

Raw Pinelliae Rhizoma: examination of sedative and hypnotic effects in mice and chemical analysis

Effect of <dfn>Orostachys spinosa </dfn> dry extract on white rat behavior in tests with positive reinforcement

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