Intracoronary administration of autologous adipose tissue-derived stem cells improves left ventricular function, perfusion, and remodelling after acute myocardial infarction

Abstract

This is the first study to show that not only bone marrow-derived cells but also ADSCs engrafted in the infarct region 4 weeks after intracoronary cell transplantation and improved cardiac function and perfusion via angiogenesis.

Once fat was fat and that was that : our changing perspectives on adipose tissue

“…124 Furthermore, such cells were used to improve cardiac function and increase survival rate in a rodent model of myocardial infarction. 124 Similar results were obtained in experiments in which undifferentiated ADSCs were transplanted into rodent 125,126 and porcine 127 infarcted hearts. These data suggest that at least in non-human models of myocardial infarction, ADSCs may be used to repair damaged cardiac tissue, although their utility in humans is still not known and requires further investigation.…”

Isolation, Characterization and Differentiation Potential of Cardiac Progenitor Cells in Adult Pigs

“…In particular, mesenchymal stem cells obtained in this species have been widely used to explore new delivery methods (Liu et al 2004) and resulted in successful engraftment and differentiation into cardiomyocytes (Makkar et al 2005). Cardiogenic stem cells have also been derived from pig adipose tissue (Valina et al 2007) and from amniotic fluid-derived mesenchymal cells (Sartore et al 2005).…”

“…Finally, both endothelial (Zeisberg et al 2007) and epicardial (van Tuyn et al 2007) cells become activated after injury and give rise to cardiac, vascular and myofibroblast/smooth muscle cells resuming their capacity during development. In particular, during heart development, cells from the proepicardial organ spread over the naked heart tube to form the epicardium.…”

“…In addition, direct intramyocardial injection of MSCs results in successful engraftment and differentiation into cardiomyocytes and endothelial cells and preserves left ventricular function in acute (Makkar et al 2005) and chronic myocardial lesions (Schuleri et al 2009). Cardiogenic stem cells have been derived from pig adipose tissue (ADSCs) and can engraft in the infracted region four weeks after transcatheter intracoronary cell transplantation improving cardiac function and perfusion via angiogenesis with an efficiency comparable to that of bone marrow-derived stem cells (Valina et al 2007 Recently, an exhaustive study reported the isolation of a c-kit + /CD45 -cardiogenic cell population from weanling pigs (Figure 16) (Ellison et al 2011), demonstrating a robust regenerative effect of these cells that are most likely involved in the myocardium hyperplastic growth and maturation to adulthood, consistent with data previously shown in neonatal mice . Physiological similarities with humans extend to the endocrine system enabling the study of the cardioprotective effect of drugs modulating the reninangiotensin pathway (Jugdutt et al 2004).…”

“…Sheep instead contained mesenchymal stem cells (Kalfa et al 2010), bone marrow-derived cells (Vincentelli et al 2007), endothelial progenitor cells (Sales et al 2010) and skeletal muscle satellite cells (Ghostine et al 2002). Pig was characterized for the presence of cardiogenic cells, such as bone marrow-derived cells (Kamihata et al 2001;Bhakta et al 2006;Makela et al 2007;Doyle et al 2008;Pak et al 2003;He et al 2007;Liu et al 2004), adipose tissue cells (Valina et al 2007), amniotic fluid-derived mesenchymal cells (Sartore et al 2005) and resident cardiac stem cells, recently described in weanling pigs .…”