Intracranial electrophysiology helps define pathological networks and optimize stimulation approaches in deep brain stimulation for treatment-resistant depression

Why are clinical trials of deep brain stimulation terminated? An analysis of clinicaltrials.gov

“…Of these unsuccessful trials for experimental conditions, most were for treatment-resistant depression (TRD) with a few studies that were aborted due to concern for futility. 30 , 31 More recent studies have shown promise by utilizing a network-based approach that implement stereoelectroencephalography (SEEG) electrodes or DBS leads with chronic local field potential-sensing capabilities to identify and map the dysfunctional network prior to implementing DBS, 32 , 33 , 34 , 35 , 36 but increased understanding of these networks will be required to optimize utilization of DBS for TRD.…”