Intracranial Extension of Acinic Cell Carcinoma of the Parotid Gland

Spencer, M. Loreto; Neto, Antonio Galvao; Fuller, Gregory N.; Luna, Mario A.

doi:10.5858/2005-129-780-ieoacc

Cited by 8 publications

(2 citation statements)

References 15 publications

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“…For patients in which a last follow-up appointment was reported (n = 5), patients were noted to be in good health at a minimum of 11 months following treatment, with no postoperative deaths reported in any cases previously published in the literature. The results are shown in Table 1 [4][5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Parotid Acinic Cell Carcinoma with Intracranial Metastasis: A Case Report and Literature Review

F¹,

Bayard²,

Hilda³

et al. 2022

J Head Neck Surg

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Introduction: Acinic cell carcinoma is a rare salivary gland neoplasm frequently associated with local recurrence. While distal metastasis occurs in approximately 19% of cases, intracranial metastasis has been rarely reported in the literature and both preoperative patient characteristics and postoperative prognoses are not currently well-characterized. Methods:In this study, we conducted a systematic review of all relevant studies in the Pubmed database and presented a case series of salivary gland acinic cell carcinomas with intracranial metastasis found in the literature. All relevant studies were reviewed, and information related to the number of patient(s) described, their sex and age, presenting symptoms, location of metastasis, treatment, and time intervals from initial diagnosis and intracranial metastasis and from treatment for intracranial metastasis to last reported follow-up were recorded.Results: Seven studies matching the inclusion criteria were included for data collection and further analysis. The mean age of presentation was 48.9 ± 11.9 years, with intracranial metastasis occurring, on average, 8.7 ± 10.3 years following the initial diagnosis of acinic cell carcinoma. All patients with reported treatment modalities received either surgical resection and/or radiation therapy. The minimum postoperative follow-up for these patients occurred at 11 months, with no postoperative deaths reported in any cases previously published in the literature. Conclusion:Parotid acinic cell carcinoma is a frequently recurring salivary gland neoplasm with metastatic potential, often many years following initial diagnosis. Though intracranial metastasis has only rarely been reported in the literature and associated with increased management complexity, patients demonstrate a positive prognosis following treatment.

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Section: Introductionmentioning

confidence: 99%

Parotid Acinic Cell Carcinoma with Intracranial Metastasis: A Case Report and Literature Review

F¹,

Bayard²,

Hilda³

et al. 2022

J Head Neck Surg

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“…-El patrón folicular se parece a los folículos tiroideos con septos de epiteliocitos rodeados por espacios ocupados con material eosinófilo. Las metástasis son infrecuentes en el CCA y, cuando suceden, tienen preferencia por los nodos linfoides regionales, aunque se describen diseminaciones a distancia principalmente en pulmón, hueso y cerebro, las que se asocian a un mal pronóstico [9][10] . El objetivo de este trabajo fue analizar 12 casos de CCA según su localización, características clínicas, patrón histológico, inmunohistoquímico y tipos celulares, siguiendo la última clasificación de la Organización Mundial de la Salud.…”

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Aciniccell carcinoma of the salivary glands: clinical and histopathological study of 12 cases

Me¹,

A²,

Ferraris³

et al. 2021

RevFacOdont

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Objective:Acinic cell carcinoma (CCA) is the third malignant epithelial tumor of the salivary glands in adults; low-grade tumor of malignancy, composed of neoplastic cells with serous acinar differentiation. The objective of this work was to analyze 12 cases of CCA according to their location, clinical characteristics, histological and immunohistochemical pattern and cell types, following the latest classification of the World Health Organization. Methods: The study included 12 cases of CCA from the files of salivary tumor biopsies of our work team, corresponding to the period 1997-2020. A numerical code was used to identify the samples, preserving the identity of the patients. Histological sections of the paraffin-embedded biopsies were evaluated with H/E, PAS and Toluidine blue and immunostained with the monoclonal antibodies pancytokeratin AE1 / AE3, Ki67, MUC-1 and mammaglobin. Results: The most frequent histologic pattern was the solid type as a single pattern or integrated with other patterns of lesser development, with almost exclusive location in the parotid gland and more frequent in women. Cells like normal acinar serocytes predominated in the solid growth pattern. The most frequent cell type in the microcystic patternwas the nonspecific glandular cell together with a lower proportion of acinar and intercalated duct-like cells. The papillary-cystic pattern was lined by nonspecific glandular cells. No clear cells found. With Ki67 a low cell proliferation was demonstrated in all the cases studied. Cell labeling for MUC-1 was grade 1 positive (less than 10% immunoreactive cells) and negative for mammaglobin.Conclusions: Patient follow-up is a priority because CCA tends to recur and metastasize and its behavior can become aggressive. We must deepen the study of its proliferative capacity as a treatment and prognosis tool, especially with immunohistochemistry and standardized molecular biology methods.

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Acinic Cell Carcinoma of Parotid Gland: Report of Three Cases and Literature Review

Oliveira

Soave

Costa

et al. 2010

Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurg

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Intracranial Extension of Acinic Cell Carcinoma of the Parotid Gland

Cited by 8 publications

References 15 publications

Parotid Acinic Cell Carcinoma with Intracranial Metastasis: A Case Report and Literature Review

Parotid Acinic Cell Carcinoma with Intracranial Metastasis: A Case Report and Literature Review

Aciniccell carcinoma of the salivary glands: clinical and histopathological study of 12 cases

Acinic Cell Carcinoma of Parotid Gland: Report of Three Cases and Literature Review

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