Intracranial meningeal melanocytoma: a cause of high signal on T1- and low signal on T2-weighted MRI

Offiah, Chika; Laitt, Roger

doi:10.1016/j.crad.2005.10.012

Cited by 19 publications

(17 citation statements)

References 12 publications

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“…It has been reported that MM might transform into malignant melanoma 9,17 and then cause distant metastasis. 28 Our study also supports multifocal MM possibly predicting a poor outcome.…”

Section: Discussionsupporting

confidence: 65%

“…7,12 The absence of a reaction to Leu-7 excludes the diagnosis of melanocytic schwannoma. 7,28 Vimentin usually appears in MM but is only rarely present in malignant melanoma. Ultrastructurally, desmosomes are characteristic of meningioma but are generally absent in MM.…”

Section: Discussionmentioning

confidence: 99%

“…6,25,26 The cytologic feature of MM is uniform, lacking in atypia and mitotic activity and showing different degrees of melanization. 12,[27][28][29][30] IHC staining is always indispensable for differentiating MM from other pigmented tumors. MM is characterized by a positive reaction to HMB-45, vimentin, and S-100 proteins 12 and a negative reaction to EMA and Leu-7.…”

Section: Discussionmentioning

confidence: 99%

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MR Imaging Findings of the Intraspinal Meningeal Melanocytoma: Correlation with Histopathologic Findings

Hou

Sun

Zhang

et al. 2012

AJNR Am J Neuroradiol

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SUMMARY:Our aim was to better understand and improve the accuracy of the preoperative diagnosis of intraspinal MM by a combined analysis of MR imaging and pathologic findings. All 5 patients had undergone unenhanced and contrast-enhanced MR imaging examinations. All tumor samples had immunohistochemical reactions to HMB-45, vimentin, S-100, EMA, and Leu-7 antibodies. All 5 cases were located in the intradural extramedullary compartment. Two cases had multifocal lesions, and 3 cases were solitary. Two cases showed homogeneously strong enhancement, and 3 cases showed moderate enhancement on contrast-enhanced T1WI. The tumor cells had positive reactions to HMB-45, vimentin, and S-100 antibodies. MR imaging plays an important role in the detection and diagnosis of intraspinal MM. Final diagnosis should be based on histopathology and IHC examinations.ABBREVIATIONS: EMA ϭ epithelial membrane antigen; HMB-45 ϭ human melanoma black-45; IHC ϭ immunohistochemistry; MM ϭ meningeal melanocytoma P rimary melanocytic neoplasms of the CNS are lesions arising from melanocytes of the leptomeninges. Melanocytes are melanin-producing cells that derive from the neural crest during embryogenesis and then migrate to the skin, mucous membranes, and CNS.

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“…It has been reported that MM might transform into malignant melanoma 9,17 and then cause distant metastasis. 28 Our study also supports multifocal MM possibly predicting a poor outcome.…”

Section: Discussionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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MR Imaging Findings of the Intraspinal Meningeal Melanocytoma: Correlation with Histopathologic Findings

Hou

Sun

Zhang

et al. 2012

AJNR Am J Neuroradiol

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“…The symptoms related to melanocytomas depend on their location. [7] The tumor in our case was present at the lower dorsal level and hence the patient presented with symptoms in the lower limb. The melanin pigment of melanocytomas give a characteristic MRI appearance due to its paramagnetic effect.…”

Section: Discussionmentioning

confidence: 87%

Intramedullary melanocytoma of thoracic spine: A rare case report

et al. 2014

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Melanocytomas are present in leptomeninges and arise from neural crest during early embryonic development. They are a rare entity and usually occur in the thoracic spine and infratentorial region. We report a 32-year-old female with meningeal melanocytoma of D9-10. Magnetic resonance imaging revealed an intramedullary spinal tumor at D9-D10. Intraoperatively, the tumor was greyish-black in color with moderate vascularity, and was adherent to the cord. The clinical differential diagnoses included cavernoma and melanocytoma. On microscopic examination, the lesion showed sheets of cells with marked pigment deposition, which was obscuring the cellular morphology. The pigment was confirmed to be melanin by Masson's Fontana stain. Immunohistochemistry was performed, which showed positivity for HMB-45, S-100, Vimentin and Melan-A. The cells were negative for cytokeratin, epithelial membrane antigen, Glial fibrillary acidic protein and neuron-specific enolase. Mib-1 labeling index was less than 1%. In view of the lack of nuclear atypia, mitoses, necrosis and low Mib-1-labeling index along with immunohistochemistry profile, the diagnosis of Melanocytoma was made. Melanocytomas are rare pigmented tumors of the spinal cord and posterior cranial fossa. They are benign in nature, but can also be locally aggressive. Melanocytic lesions of the nervous system are to be differentiated from metastatic melanomas and also tumors showing melanin pigment deposition like schwanomma, paraganglioma, medulloblastoma and various gliomas.

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“…[69][70][71][72] Differential considerations for melanocytoma include pigmented meningioma, melanotic schwannoma, and melanoma. Melanocytomas are suspected to arise from melanocytes, which are cells of neural crest origin to be found scattered along the surface of the brain.…”

Section: Melanocytic Lesionsmentioning

confidence: 99%