Intracranial meningioma as primary presentation for an undiagnosed collision metastatic breast cancer: Case report and literature review

Farrag, Ashraf; Ansari, Jawaher; Ali, Muhammad; Sunbuli, Ghanem; Kassem, Hassan; Hamad, Abdulaziz Al

doi:10.3892/mco.2018.1589

Cited by 6 publications

(5 citation statements)

References 27 publications

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“…It is sometimes confused with a collision tumor, which possesses similar characteristics as TTM. It is crucial to differentiate TTM from a collision tumor, which refers to the presence of two histologically distinct tumors within an anatomic location with infiltration of the tumors into one another [ 5 6 7 ]. Syed et al [ 7 ] reported that understanding the distinction between a collision tumor and TTM is necessary to plan the surgical approach and management.…”

Section: Discussionmentioning

confidence: 99%

“…Most intra-meningioma metastases are diagnosed histopathologically, and they cannot be accurately diagnosed using CT or MRI. Furthermore, it is difficult to differentiate TTM from a collision tumor using MRI [ 5 ]. However, MRI may be used to identify rapid growth, peritumoral edema, irregular margins, mushroom pattern, and heterogeneous enhancement, which have been reported previously [ 7 13 ].…”

Section: Discussionmentioning

confidence: 99%

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Breast Cancer to Meningioma: A Rare Case of Tumor-to-Tumor Metastasis

Joe

Lee

Kim

et al. 2023

Brain Tumor Res Treat

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Tumor-to-tumor metastasis (TTM) is defined as the hematogenous metastasis within a primary host tumor from a donor neoplasm. Since there is insufficient evidence regarding the pathophysiology, clinical course, and management of TTM, there are no precise guidelines for its management. A 73-year-old female patient diagnosed with breast cancer was found to have convexity meningioma. Since the size of tumor and peritumoral brain edema increased during follow-up period, the meningioma was treated with surgical resection. Postoperatively, histopathologic examination confirmed metastasis of invasive ductal carcinoma within a secretory meningioma. The final diagnosis was TTM of breast cancer in meningioma. Here, we report a rare case of intra-meningioma metastasis and a review of literature to provide a better understanding of this rare phenomenon.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Breast Cancer to Meningioma: A Rare Case of Tumor-to-Tumor Metastasis

Joe

Lee

Kim

et al. 2023

Brain Tumor Res Treat

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“…Postoperative oncological treatment depended on the type of malignant tumour, type of spread and of course general and oncological state of a patient. Some patients died before starting any oncological treatment, radiotherapy or chemotherapy [12,17,22,28,49,59].…”

Section: Discussionmentioning

confidence: 99%

Metastases to cranial base meningiomas. Clinical presentations and surgical outcomes. Literature overview

Rzehak¹,

Sobstyl²,

Bojarski³

2022

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Tumour-to-meningioma metastasis (TTMM) is an uncommon phenomenon, however repeatedly found in the literature. Meningiomas occur to be the most frequent target of metastatic expansion of systemic cancers. Meningiomas often vary in symptoms and treatment, and this largely depends on the tumour location. Due to their variable locations, they can be classified as convexity meningiomas, which includes falcine and parasagittal tumours, and cranial base, which includes tumours located in the olfactory groove, sphenoid wing, petrous bone and other cranial base locations. The aim of this study was to analyse all data regarding metastases to cranial base meningiomas. We performed a literature search to locate all cases of metastases to cranial base meningiomas in PubMed and Medline databases using the following key words: metastasis to meningioma, meningioma metastasis, and cranial base meningioma. We collected patient and cancer parameters, exact meningioma location and clinical presentations including characteristics which may suggest TTMM. We found 100 articles describing 111 patients of metastasis to cranial base meningioma. Among these articles, 55 cases (49.55%) included metastases to non-skull base meningiomas. In 24 cases (21.62%), the location of meningioma was not precisely described or other data were unavailable, in particular histopathological examination. The most common location of TTMM was sphenoid wing, which was found in 9 patients. The other locations included cerebellopontine angle in 5 patients, and tuberculum sellae in 3 cases. 81.25% cases of TTMM were reported in women, and the most common cancer origins were the breast (28.3%), lung (18.7%), kidney (9.38%) and prostate (9.38%). In two cases the metastatic origin was unclear, and in 15.6% of cases the patients were in remission for more than 1 year. In 78.1% of cases patients presented focal deficits, followed by increased intracranial pressure, and seizures. In almost one-third of cases, TTMM first appeared from a previously unknown cancer. Rapid clinical presentation of cranial nerve palsies may suggest the dual nature of intracranial pathology. The metastasis to cranial base meningioma should be suspected in patients with oncological background, regardless of meningioma parameters or cancer status.

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“…Moreover, conditions such as protection of tumoral tissue from immune surveillance, decreased expression of the tumor suppressor genes, and the existence of cellular and hormonal signaling could potentially play a role in tumor-to-meningioma metastasis. [ 6 , 12 , 14 , 19 ]…”

Section: Discussionmentioning

confidence: 99%

“…Limitation of routine imaging workups like CT or MRI in differentiation between these possible diagnoses affirms the importance of careful pathological analysis as the tumor-to-tumor metastasis could be missed if the whole tumor is not carefully sampled. [ 12 ]…”

Section: Discussionmentioning

confidence: 99%

Meningioma as the host for metastatic breast cancer: A rare occurrence with important therapeutic impact

Hosseinzadeh

Ketabchi

Ahmadi

et al. 2021

Surgical Neurology International

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Background: Tumor-to-tumor metastasis is a rare condition. There are few reports of metastatic tumors within intracranial tumors, including meningiomas. Since some metastatic tumors have osteoblastic imaging pattern, it is not always easy to differentiate them from meningioma on preoperative studies. Case Description: A 60-year-old female referred to our center complaining about a progressive headache, nausea, and vomiting for the past month. She had a history of breast cancer treated with radical mastectomy (5 years ago) and adjuvant chemotherapy (until 1 year ago). Workups revealed a dural-based mass in the left temporobasal and midline subfrontal regions. Histopathological study showed breast cancer metastasis nests within the primary meningioma. Conclusion: As the diagnosis of metastatic nests inside a benign tumor, drastically alters postoperative adjuvant treatments, a high index of suspicion is needed evaluating tumors from patients with a history of systemic neoplasms.

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Intracranial meningioma as primary presentation for an undiagnosed collision metastatic breast cancer: Case report and literature review

Cited by 6 publications

References 27 publications

Breast Cancer to Meningioma: A Rare Case of Tumor-to-Tumor Metastasis

Breast Cancer to Meningioma: A Rare Case of Tumor-to-Tumor Metastasis

Metastases to cranial base meningiomas. Clinical presentations and surgical outcomes. Literature overview

Meningioma as the host for metastatic breast cancer: A rare occurrence with important therapeutic impact

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