Intracranial meningioma with carcinoma tumor-to-tumor metastasis: two case reports

Pham, Jason; Kim, Ronald C.; Nguyen, Anna; Bota, Daniela; Kong, Xiangdong; Vadera, Sumeet; Hsu, Frank P.K.; Carrillo, Jose

doi:10.2217/cns-2017-0022

Cited by 20 publications

(12 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since then, many other tumor-derived factors, including cytokines, chemokines, extracellular matrix components, small noncoding RNAs and tumor-shed extracellular vesicles have been shown to act as systemic signals that trigger the formation of premetastastic niches in lung, liver or lymph nodes in different preclinical models (149,261). Clinical evidence for the existence of premetastatic tissues comes from patients with meningioma (a benign brain tumor) who later progress with tumor-to-meningioma metastasis of breast, lung or renal cancer (88,264,270). It is suggested that the presence of pro-inflammatory macrophages and the high microvascular density in meningioma contribute to metastasis formation (88).…”

Section: A Preparing the Soil -The Concept Of The Premetastatic Nichementioning

confidence: 99%

Bone metastasis: mechanisms, therapies, and biomarkers

Clézardin

Coleman

Puppo

et al. 2021

Physiological Reviews

235

160

View full text Add to dashboard Cite

Skeletal metastases are frequent complications of many cancers, causing bone complications (fractures, bone pain, disability), which negatively affect the patient's quality of life. Here, we first discuss the burden of skeletal complications in cancer bone metastasis. We then describe the pathophysiology of bone metastasis. Bone metastasis is a multistage process; long before the development of clinically detectable metastases, circulating tumor cells settle and enter a dormant state in normal vascular and endosteal niches present in the bone marrow, which provide immediate attachment and shelter, and only become active years later as they proliferate and alter the functions of bone-resorbing (osteoclasts) and bone-forming (osteoblasts) cells, promoting skeletal destruction. The molecular mechanisms involved in mediating each of these steps are described and we also explain how tumor cells interact with a myriad of interconnected cell populations in the bone marrow, including a rich vascular network, immune cells, adipocytes and nerves. We discuss metabolic programs that tumor cells could engage with to specifically grow in bone. We also describe the progress and future directions of existing bone-targeted agents and report emerging therapies that have arisen from recent advances in our understanding of the pathophysiology of bone metastases. Finally, we discuss the value of bone turnover biomarkers in detection and monitoring of progression and therapeutic effects in patients with bone metastasis.

show abstract

Section: A Preparing the Soil -The Concept Of The Premetastatic Nichementioning

confidence: 99%

Bone metastasis: mechanisms, therapies, and biomarkers

Clézardin

Coleman

Puppo

et al. 2021

Physiological Reviews

235

160

View full text Add to dashboard Cite

show abstract

“…For diagnosis of TTM, Campbell et al proposed the following criteria: at least 2 primary tumors must exist, the metastatic focus must show established growth inside the host tumor and not be of contiguous growth, and the host tumor must be a true neoplasm and cannot be a lymph node involved in leukemia or lymphoma. [ 1 , 35 ] Our case fulfilled the inclusion criteria for TTM established by Campbell et al Previous studies presented different hypotheses related to the reasons why meningioma is the most common intracranial host in TTM. Meningiomas can provide an accessible and favorable environment for growth to receive metastases [ 19 ] because they are highly vascular tumors [ 36 ] and exhibit slow growth and an indolent nature.…”

Section: Discussionmentioning

confidence: 84%

Metastasis of pulmonary adenocarcinoma to right occipital parafalcine meningioma

Wang

Song

et al. 2020

Medicine

View full text Add to dashboard Cite

Rationale: Tumor-to-tumor metastasis is a rare clinical phenomenon. Although meningioma is the most common intracranial recipient of cancer metastasis, only a few cases have been reported. We present a case of metastasis of lung adenocarcinoma into intracranial meningioma and review the published literature. Patient concerns: A 70-year-old woman was admitted to our hospital for a 1-month history of headache and pain in her lower extremities. Diagnosis: Brain and lumbar vertebral magnetic resonance imaging showed an intracranial space-occupying lesion in the right occipital region and spinal canal stenosis. Pulmonary computed tomography showed an irregular mass in the right upper lobe of the lung. The postoperative histological examination demonstrated adenocarcinoma metastasis to meningioma. Intervention: The patient underwent right occipital craniotomy for tumor removal and lumbar spinal canal decompression. Outcomes: There were no initial abnormal conditions after the operation. However, the patient died suddenly 7 days after surgery. Lessons: Tumor-to-meningioma metastasis is a rare but important phenomenon. According to previous reports, it is associated with rapid onset of symptoms and a poor prognosis. Histological examination is of great importance in diagnosis. The history and process of malignant carcinoma should be closely monitored.

show abstract

“…TTM is also an uncommonly described phenomenon throughout the human medicine literature, with <100 cases affecting the CNS. 27 , 28 To our knowledge, only two cases of TTM have been described in the veterinary literature: one of a right heart auricle haemangiosarcoma with mammary gland tumour metastasis, 29 and the second of a forebrain oligodendroglioma hosting prostatic adenocarcinoma metastasis. 30 In people, meningioma represents the most frequent recipient tumour with TTM phenomenon affecting the CNS.…”

Section: Discussionmentioning

confidence: 99%

Cerebral meningioma associated with extensive calvarium osteolysis and presumed intratumoral carcinoma metastasis in a cat

Dussaux

Gomes

Hurion

et al. 2022

Journal of Feline Medicine and Surgery Open Reports

View full text Add to dashboard Cite

Case summary A 10-year-old male neutered domestic shorthair cat presented with a 3-month history of weight loss, dysorexia and lethargy. Neurological examination revealed decreased mentation, absent menace response bilaterally and proprioceptive deficits affecting all four limbs; these findings were consistent with a forebrain disorder. Brain CT revealed an extensive asymmetric permeative osteolysis destroying two-thirds of the circumference of the calvarium and involving the right frontal, parietal, temporal and occipital bones, as well as the left parietal bone. This extensive bone lysis was associated with a large ‘plaque-like’ extra-axial subdural/pachymeningeal lesion extending within the soft tissues surrounding the calvarium. The cat was humanely euthanased. Post-mortem MRI was performed, which revealed a T2-weighted (T2W) hypointense subdural lesion and a T2W hyperintense circumferential extracranial lesion lining the right calvarium and left parietal bone. Histopathological analysis on a post-mortem sample of the lesion revealed a fibroblastic subtype of meningioma. Epithelial neoplastic cells were observed scattered through the meningioma, calvarium and surrounding muscular tissues, corresponding with presumed metastatic carcinoma. Relevance and novel information To our knowledge, this is the first report of an intracranial meningioma associated with such an extensive and diffuse calvarial osteolysis in veterinary medicine. This is also the first description of presumed metastatic inclusions (adenocarcinoma in this case) inside an intracranial feline meningioma, which is a rare phenomenon known as tumour-to-tumour metastasis in human medicine.

show abstract

Intracranial meningioma with carcinoma tumor-to-tumor metastasis: two case reports

Cited by 20 publications

References 25 publications

Bone metastasis: mechanisms, therapies, and biomarkers

Bone metastasis: mechanisms, therapies, and biomarkers

Metastasis of pulmonary adenocarcinoma to right occipital parafalcine meningioma

Cerebral meningioma associated with extensive calvarium osteolysis and presumed intratumoral carcinoma metastasis in a cat

Contact Info

Product

Resources

About