Intracranial mesenchymal chondrosarcoma

Seth, H. N.; Singh, Mahendra

doi:10.1007/bf00691422

Cited by 19 publications

(2 citation statements)

References 8 publications

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“…3 As a peculiarity of this neoplasm, about one third of the cases develop outside the bone including a significant number arising in the meninges. 1,[5][6][7][8][9] Mesenchymal chondrosarcoma was first described as mesenchymoma/polyhistioma by Jacobson 10 and is composed of two characteristic tumor components: one being highly cellular and the other showing cartilage formation with abundant extracellular matrix.…”

Section: (Am J Pathol 2000 156:1327-1335)mentioning

confidence: 99%

Cell Differentiation and Matrix Gene Expression in Mesenchymal Chondrosarcomas

Aigner

Loos

Müller

et al. 2000

The American Journal of Pathology

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Mesenchymal chondrosarcomas are small-cell malignancies named as chondrosarcomas due to the focal appearance of cartilage islands. In this study, the use of in situ detection techniques on a large series of mesenchymal chondrosarcoma specimens allowed the identification of tumor-cell differentiation pathways in these neoplasms. We were able to trace all steps of chondrogenesis within mesenchymal chondrosarcoma by using characteristic marker genes of chondrocytic development. Starting from undifferentiated cells, which were negative for vimentin and any other mesenchymal marker, a substantial portion of the cellular (undifferentiated) tumor areas showed a chondroprogenitor phenotype with an onset of expression of vimentin and collagen type IIA. Cells in the chondroid areas showed the full expression panel of mature chondrocytes including type X collagen indicating focal hypertrophic differentiation of the neoplastic chondrocytes. Finally, evidence was found for transdifferentiation of the neoplastic chondrocytes to osteoblast-like cells in areas of neoplastic bone formation. These results establish mesenchymal chondrosarcoma as the very neoplasm of differentiating premesenchymal chondroprogenitor cells. The potential of neoplastic bone formation in mesenchymal chondrosarcoma introduces a new concept of neoplastic (chondrocytic) osteogenesis in musculoskeletal malignant neoplasms, which qualifies the old dogma that neoplastic bone/osteoid formation automatically implies the diagnosis of osteosarcoma.

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Section: (Am J Pathol 2000 156:1327-1335)mentioning

confidence: 99%

Cell Differentiation and Matrix Gene Expression in Mesenchymal Chondrosarcomas

Aigner

Loos

Müller

et al. 2000

The American Journal of Pathology

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“…3 As a particularity of this neoplasm, about one-third of the cases develop outside the bone, including a significant number of them arising in the meninges. 1,[5][6][7][8][9] Morphologically, mesenchymal chondrosarcoma is mainly composed of two characteristic tumor components: one being highly cellular and poorly differentiated and the other showing cartilage formation.…”

mentioning

confidence: 99%

Type II collagen as specific marker for mesenchymal chondrosarcomas compared to other small cell sarcomas of the skeleton

et al. 2005

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Mesenchymal chondrosarcoma is a rare, usually highly malignant chondrogenic neoplasm. The diagnosis of mesenchymal chondrosarcoma can be challenging, it nonetheless has important therapeutic and diagnostic implications. Thus, biopsies of mesenchymal chondrosarcomas without conspicuous cartilaginous differentiation cannot be safely distinguished from other small cell mesenchymal neoplasms such as Ewing's sarcoma and peripheral neuroendrocrine tumors, synovial sarcomas and hemangiopericytomas, because all of these neoplasms might show overlapping histological features, and so far, there have been no safe immunohistochemical markers available in order to differentiate these neoplasms. In our study on a large series of mesenchymal chondrosarcomas (n ¼ 30) and other small cell sarcomas (Ewing's sarcomas (n ¼ 12), synovial sarcomas (n ¼ 6), hemangiopericytomas (n ¼ 5), small cell osteosarcomas (n ¼ 3), and desmoplastic small round cell tumors (n ¼ 1)), we could establish the presence of type II collagen in the extracellular tumor matrix of the small cell areas of mesenchymal chondrosarcomas as a specific and sensitive marker to identify mesenchymal chondrosarcomas and to exclude other small cell neoplasms (except chondroblastic areas in small cell osteosarcomas). In contrast, the S-100 protein was less sensitive and vimentin and total collagen content unspecific for discriminating these neoplasms. Thus, the presence of type II collagen in the extracellular tumor matrix significantly facilitates the diagnosis of mesenchymal chondrosarcomas in the absence of histologically visible chondroid matrix formation.

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Meningeal mesenchymal chondrosarcoma. Report of 8 cases with review of the literature

Scheithauer

Rubinstein

1978

Cancer

134

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This paper reviews 8 personally examined cases of primary meningeal mesenchymal chondrosarcoma and 4 similar cases previously reported by others. The clinicopathologic features of these extraosseous intracranial and intraspinal examples are similar to those of other extraskeletal mesenchymal chondrosarcomas. The tumor occurred most often in the second and third decades, showed a moderate tendency to local recurrence (5 of 12 cases) and occasionally metastasized to the lungs (1 case). Both intracranial and intraspinal tumors occurred with equal frequency, but the former, probably due to the later onset of symptoms, had the worse prognosis. Microscopically, they are composed of primitive undifferentiated mesenchymal cells and frequently well-defined islands of hyaline cartilage. There is an apparent correlation between the frequency of mitotic figures and the likelihood of recurrence and metastasis. Electron microscopic study of one example revealed morphologic features similar to those previously described by others and supports the conclusion that the neoplastic cells represent primitive precartilaginous mesenchyme displaying focal cartilaginous differentiation.

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Intracranial mesenchymal chondrosarcoma

Cited by 19 publications

References 8 publications

Cell Differentiation and Matrix Gene Expression in Mesenchymal Chondrosarcomas

Cell Differentiation and Matrix Gene Expression in Mesenchymal Chondrosarcomas

Type II collagen as specific marker for mesenchymal chondrosarcomas compared to other small cell sarcomas of the skeleton

Meningeal mesenchymal chondrosarcoma. Report of 8 cases with review of the literature

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