Intracranial metastases from an ovarian dysgerminoma in a 2-year-old dog

Fernández, Tamara; Díez-Bru, N; Rios, Adson Sales do Nascimento; Gómez, Luis O.; Pumarola, M.

doi:10.5326/15473317-37-6-553

Cited by 18 publications

(14 citation statements)

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“…In 1 retrospective study, the authors found that dysgerminomas develop in dogs ≥10 years old, whereas teratomas develop in dogs ≤9 years old 17. Metastasis is reported to develop in 10–20% of cases,1 with regional lymph nodes, liver, brain,19 and kidney as the primary sites of metastasis. Abdominal effusion may develop in association with this neoplasm 8…”

Section: Discussionmentioning

confidence: 99%

Intra‐abdominal mass aspirate from an alopecic dog

Brazzell

Borjesson

2006

Veterinary Clinical Pathol

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An 11-year-old female Yorkshire terrier was presented to the University of Minnesota Veterinary Medical Center for evaluation of a palpable intra-abdominal mass and alopecia. Abdominal ultrasonography revealed a large, complex, cavitary mass in the left caudal region of the abdomen. A fine needle aspirate of the mass was collected. A population of markedly pleomorphic, large, round to polygonal cells were found singly and in small noncohesive aggregates. The cells contained scant, clear to blue-gray cytoplasm, large, round to oval nuclei, and distinctly stippled to reticular chromatin. Cytologic findings were consistent with a tumor of ovarian origin, with a primary differential diagnosis of germ cell tumor. Hormonal analysis of serum revealed a marked increase in 14-OH-progesterone concentration (2.71 ng/mL, reference interval 0.05-0.69 ng/mL). Ovariohysterectomy was performed, and the mass was found to be in the area of the left ovary. Histologic evaluation of the reproductive tract confirmed a diagnosis of left ovarian dysgerminoma. Based on immunohistochemical stains, the tumor was negative for c-kit (CD117c) and single cells were positive for neuron-specific enolase. A right ovarian cyst and squamous metaplasia of the right uterine horn also were diagnosed. The cyst was presumed to be the source of 14-OH-progesterone, which likely resulted in the squamous metaplasia and dermatopathy. Three months after surgery, the progesterone concentration had returned to normal and the alopecia had nearly resolved. Dysgerminomas in dogs are reported rarely, but have a distinctive, recognizable, cytologic appearance and should be included in the differential diagnosis of an intra-abdominal mass in a reproductively intact female dog.

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Section: Discussionmentioning

confidence: 99%

Intra‐abdominal mass aspirate from an alopecic dog

Brazzell

Borjesson

2006

Veterinary Clinical Pathol

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“…Dysgerminoma is an uncommon ovarian tumour in domestic animals, but it has been reported in most species and most frequently in dogs (MacLachlan 1987). Dysgerminoma has its origin in primordial germ cells of the embryonic gonad and it resembles testicular seminoma in males (Fernández et al. 2001).…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemistry Diagnosis of an Ovarian Dysgerminoma in One Bitch

Park

Goo

Hong

et al. 2009

Reprod Domestic Animals

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An ovarian enlargement (diameter, 8 cm) was identified and surgically excised from a 5-year-old female dog. Microscopic examination of the multinodular neoplasm revealed sheets of polygonal neoplastic cells with large nuclei, frequent mitosis, necrosis and haemorrhage. Immunohistochemically, the neoplastic cells were positive for vimentin and alkaline phosphatase but were negative for CD3, CD79a, cytokeratin, alpha-fetoprotein, inhibin-alpha and S-100. The histopathological diagnosis of the mass was unilateral ovarian dysgerminoma.

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“…The incidence of secondary brain tumors may be increasing because animals with systemic malignancies are now being treated more aggressively with chemotherapeutic agents that prolong lifespan, allowing more time for intracranial metastasis to occur 1 . Alternatively, the incidence of secondary tumors of the brain may have been underrepresented previously because the cranial vault was not routinely examined as a metastatic site 3,4 . In dogs, carcinomas account for the majority of reported brain metastases, followed by sarcomas 1,5…”

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confidence: 99%

“…1 Alternatively, the incidence of secondary tumors of the brain may have been underrepresented previously because the cranial vault was not routinely examined as a metastatic site. 3,4 In dogs, carcinomas account for the majority of reported brain metastases, followed by sarcomas. 1,5 Although intracranial neoplasia is well described in the dog, few reports in this species have focused on secondary tumors of the brain.…”

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confidence: 99%

Secondary Intracranial Neoplasia in the Dog: 177 Cases (1986–2003)

Snyder

Lipitz

Skorupski

et al. 2008

Veterinary Internal Medicne

111

113

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Background: This study investigates the frequency, location, and clinical findings associated with 177 secondary brain tumors in dogs.Hypothesis: Secondary intracranial neoplasia is more common than primary intracranial neoplasia in dogs during the time period studied, and hemangiosarcoma (HSA) is the most common secondary intracranial tumor.Animals: One hundred and seventy-seven client-owned dogs presented to the Matthew J. Ryan Veterinary Hospital between 1986 and 2003.Methods: Medical records were searched for a diagnosis of intracranial neoplasia in dogs who underwent complete postmortem examination. Of these dogs, those with a diagnosis of primary intracranial neoplasia were excluded.Results: Of the 177 secondary brain tumors, 51 (29%) were HSAs, 44 (25%) were pituitary tumors, 21 (12%) were lymphosarcomas, and 21 (12%) were metastatic carcinomas. The average age at diagnosis was 9.6 AE 3.0 years. Most tumors were located in the cerebrum, and a mentation change was the most common presenting clinical sign. On postmortem examination, the same tumor that was in the brain was also present in the lung in 84 cases (47%), in the kidney in 62 cases (35%), and in the heart in 55 cases (31%).Conclusions and Clinical Importance: Secondary intracranial neoplasia in dogs was more common than primary intracranial neoplasia during the time period studied. Many of these dogs had related disease in other body systems that was apparent on diagnostic tests such as thoracic radiography.

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Intracranial metastases from an ovarian dysgerminoma in a 2-year-old dog

Cited by 18 publications

References 0 publications

Intra‐abdominal mass aspirate from an alopecic dog

Intra‐abdominal mass aspirate from an alopecic dog

Immunohistochemistry Diagnosis of an Ovarian Dysgerminoma in One Bitch

Secondary Intracranial Neoplasia in the Dog: 177 Cases (1986–2003)

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