Intracranial neoplasmin Ibadan, Nigeria

Abstract

Objective: To determine the pattern of histopathological variants of intracranial neoplasms, relative distribution of the variants in the age groups and also to determine the gender differences that exist in these tumours. Design: Case control study. Setting: Department of Pathology, University College Hospital, Ibadan, Nigeria. Patients: Two hundred and ten histologically confirmed cases of intracranial neoplasms seen during eleven-year period (1980 to 1990) were analysed. Interventions: Slides of tumours stained with haematoxylin and eosin, reticulin and phosphotungstic acid haematoxylin. Results: Two hundred and ten intracronial neoplasms comprising 172 primary and 48 secondary neoplasms were seen. One hundred and thirty five neoplasms occurred in adults and 75 in children. There was no gender difference, the ratio being 1:1. Gliomas accounted for the largest group of tumours followed by metastases to the brain. Of the gliomas, astrocytoma was the commonest. Craniopharyngiomas were found to be common in children. Germ cell tumours were found to be uncommon. Conclusion: Gliomas are the commonest group of intracranial neoplasms in both adults and children. This is followed by metastatic tumours. Tumours of the sella turcica are predominantly found in children. Involvement of the brain in disseminated Burkitt's lymphomas is predominantly found in Africans as the Burkitt's tumour is uncommon in non Africans.

Pattern of intracranial tumours in a tertiary hospital in Ghana

“…Patterns of distribution of these tumours vary across the globe. [1][2][3][4][5][7][8][9][10]12,13,17,18 This study sought to determine the pattern of intracranial tumours in neurosurgical patients with intracranial tumours who presented at Korle Bu Teaching Hospital, Accra, Ghana for treatment between January 2010 and December 2015. 102 histologically diagnosed intracranial tumours out of 335 radiologically diagnosed intracranial tumours were included in the study.…”

“…Meningioma was commoner in females as reported in other studies. 2,4,5,[7][8][9][10][11]17,18 It is also worthy of note that pituitary adenoma, metastatic tumours and craniopharyngioma, which followed gliomas and meningiomas in that order, in terms of prevalence, were all slightly commoner in females. Glioblastoma and pilocytic astrocytoma were the commonest gliomas with the former commoner in the > 45 years' age group similar to the CBTRUS study, 2 and the latter in the under 16 years' age group.…”

“…2 They are commoner among Caucasians. 3 Gliomas are the commonest group of intracranial neoplasms in both adults and children, 3,4 and are commoner in males while meningiomas are commoner in females. 3,5 Outcome of intracranial tumours varies with tumour type, location, stage at diagnosis, age of patient, functional performance score and extent of tumour resection.…”

Transition over 35 Years in the Incidence Rates of Primary Central Nervous System Tumors in Shanghai, China and Histological Subtyping Based on a Single Center Experience Spanning 60 Years

“…The remarkably much higher incidence of CNS tumors reported in North America (Zada et al, 2012) and Europe (Caldarella et al, 2011) when compared with that of Asian (Jiang et al, 2011;Manoharan et al, 2012) and African countries (Olasode et al, 2000;Afolayan, 2004;Zalata et al, 2011) may be related to factors including, but not limited to, ethnic, genetic, and epigenetic backgrounds. For instance, improvements in modern medical care system, availability of advanced diagnostic facilities, and even the quality control for the practices of caner data registration would influence the "observed" incidence rate (Ohgaki, 2009;Shin et al, 2010).…”

Recent advances in the pathology of pituitary adenomas

“…Pituitary adenomas are less common in children and studies have shown a prevalence of 2.7% of all supratentorial tumours in childhood (LAFFERTY and CHROUSOS, 1999). The prevalence of pituitary adenoma in an African population ranged from 16.8% to 21% in studies from different hospital units in Nigeria (IGUN, 2001;IDOWU, AKANG and MALOMO, 2007;OLASODE, SHOKUNBI and AGHADIUNO, 2000;OHAEGBULAM, SADDEQI and IKERIONWU, 1980).…”