Intracystic Application of Mebendazole Solution in the Treatment of Liver Hydatid Disease

Erzurumlu, Kenan; Şahi̇n, Mustafa; Selçuk, Mustafa Bekir; Yıldız, Cemil; Kesim, Mete

doi:10.1159/000129492

Cited by 17 publications

(11 citation statements)

References 12 publications

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“…[10][11][12][13][14]17,26 Percutaneous injection of mebendazole or albendazole sulfoxide without reaspiration has been attempted in both experimental and human subjects and results in effective scolicidal activity with little or no toxicity to the liver or biliary system, and local instillation has been suggested as an adjunctive to systemic chemotherapy. 27,28 The usual dose of orally-administered albendazole, with or without PAIR, is 10-15 mg/ kg/day in two divided doses, or as a fixed dose of 400 mg bid. If mebendazole is used, the daily dose is 40-50 mg/kg in three divided doses.…”

Section: Antiparasitic Chemotherapy Mebendazole and Albendazolementioning

confidence: 99%

“…For multiseptate Type III cysts or large cysts over 6 cm in size, some authors advocate the use of absolute alcohol because it is a more sclerosing agent than hypertonic saline and may destroy daughter cysts not killed by saline and may also result in a more rapid involution of the cyst cavity. 16,27,[59][60][61][62][63][64][65] Alcohol should not be used, however, if pre-existing biliary communication is suspected or documented because the agent may cause a chemical cholangitis.…”

Section: Percutaneous Drainagementioning

confidence: 99%

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Treatment options for hepatic cystic echinococcosis

Smego

Sebanego

2005

International Journal of Infectious Diseases

202

152

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A number of surgical and non-surgical options exist to treat cystic echinococcosis of the liver. For decades, surgical excision via a conservative or radical approach was the recommended approach for hepatic hydatid cysts. The availability of chemotherapeutic agents with significant activity against Echinococcus granulosis has made it possible to undertake ultrasound- or computed tomography-guided transhepatic percutaneous drainage (termed puncture, aspiration, injection, and re-aspiration (PAIR)) of hydatid cysts. Pre- and post-intervention chemotherapy with albendazole or mebendazole offers the advantage of reducing the risk of disease recurrence and intraperitoneal seeding of infection that may develop via cyst rupture and spillage occurring spontaneously or during surgery or needle drainage. PAIR appears to have greater clinical efficacy (i.e. a higher incidence of cure), lower rates of major and minor complications, mortality, and disease recurrence, and fewer days of hospitalization compared to patients treated surgically. For patients who fail drug therapy alone, PAIR is a safe and effective procedure of choice for patients with hepatic echinococcosis, and perhaps other anatomic sites of infection such as lung, peritoneum, kidney, and other viscera. Surgery should be reserved for patients with hydatid cysts refractory to PAIR because of secondary bacterial infection or for those with difficult-to-manage cyst-biliary communication or obstruction.

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Section: Antiparasitic Chemotherapy Mebendazole and Albendazolementioning

confidence: 99%

Section: Percutaneous Drainagementioning

confidence: 99%

Treatment options for hepatic cystic echinococcosis

Smego

Sebanego

2005

International Journal of Infectious Diseases

202

152

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“…A total of 1.7 µg /mL of ALB solution was used as a protoscolidal agent in the cystic cavity as previously reported [9,10]. Perioperative ALB therapy was performed in all cases.…”

Section: Methodsmentioning

confidence: 99%

Long-term outcomes of intraoperative and perioperative albendazole treatment in hepatic hydatidosis: single center experience

et al. 2014

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PurposeThe aim of this study was to evaluate long-term outcome of the intraoperative and perioperative albendazole (ALB) treatment on the recurrence and/or secondary hydatidosis.MethodsOne hundred and one patients with hepatic hydatidosis were treated intraoperatively and perioperatively with ALB, in addition to surgery. Perioperative ALB treatment was given in a dose of 12-15 mg/kg/day. The ALB treatment was started 13.27 ± 14.34 days before the surgery, and it was continued for 4.39 ± 3.11 months postoperatively. A total of 1.7 µg/mL of ALB solution was used as a protoscolidal agent. The follow-up period was 134.55 ± 51.56 months.ResultsFour patients died, with only one death was secondary to hydatid disease (cerebral eccinococcus). There was only one recurrence (1%) of hepatic hydatidosis. Early and late morbidity rates were 8.91% and 7.92%, respectively.ConclusionOur results suggest that intraoperative and perioperative ALB is effective for the prevention of hepatic hydatidosis recurrence and/or secondary hydatidosis.

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“…Although surgery is the main therapeutic approach, medical and percutaneous treatments have been used in recent years [2]. Currently, benzimidazole compounds (albendazole and mebendazole) are used in medical treatment [3]. Percutaneous treatment and injection with scolicidal compounds has become an alternative to the surgery because of successful results obtained in recent studies [4, 5].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Study of Nitric Oxide Metabolites Effects on Human Hydatid ofEchinococcus granulosus

Zeghir-Bouteldja

Amri

Aït-Aïssa

et al. 2009

Journal of Parasitology Research

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Hydatidosis is characterized by the long-term coexistence of larva Echinococcus granulosus and its host without effective rejection. Previous studies demonstrated nitric oxide (NO) production (in vivo and in vitro) during hydatidosis. In this study, we investigated the direct in vitro effects of NO species: nitrite (NO2 −), nitrate (NO3 −) and peroxynitrite (ONOO−) on protoscolices (PSCs) viability and hydatid cyst layers integrity for 24 hours and 48 hours. Our results showed protoscolicidal activity of NO2 − and ONOO− 24 hours and 3 hours after treatment with 320 μM and 80 μM respectively. Degenerative effects were observed on germinal and laminated layers. The comparison of the in vitro effects of NO species on the PSCs viability indicated that ONOO− is more cytotoxic than NO2 −. In contrast, NO3 − has no effect. These results suggest possible involvement of NO2 − and ONOO− in antihydatic action and point the efficacy of these metabolites as scolicidal agents.

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Intracystic Application of Mebendazole Solution in the Treatment of Liver Hydatid Disease

Cited by 17 publications

References 12 publications

Treatment options for hepatic cystic echinococcosis

Treatment options for hepatic cystic echinococcosis

Long-term outcomes of intraoperative and perioperative albendazole treatment in hepatic hydatidosis: single center experience

In Vitro Study of Nitric Oxide Metabolites Effects on Human Hydatid ofEchinococcus granulosus

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