Intracytoplasmic enzymes in gingival crevicular fluid of patients with aggressive periodontitis

Castro, Cecilia E.; Koss, Myriam A.; López, Marı́a Elena

doi:10.1111/j.1600-0765.2011.01367.x

Cited by 9 publications

(13 citation statements)

References 27 publications

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“…Similar results were obtained in subjects with chronic periodontitis [10]. As periodontal disease is progressing, destructive processes develop in the alveolar bone, and ACP [22] is released as a result of an increased osteoclastic activity. Our results show that the ACP activity in the saliva of patients with AP was reduced, two months after the basic and surgical therapy, but without a statistical correlation.…”

Section: Discussionsupporting

confidence: 81%

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Analysis of biochemical markers in the saliva and correlation with clinical parameters in patients with aggressive periodontitis, before and after the therapy

et al. 2021

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Introduction/Objective. Aggressive periodontitis (AP) is a progressive disease that leads damage to periodontal tissues. The aim of the study was the analysis of intracellular enzymes: aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), acid phosphatase (ACP) and electrolytes in the saliva of patients with AP and their correlation with clinical parameters before and after the therapy. Methods. The study included 30 patients with AP (experimental group) and 35 patients with healthy parodontium (control group). Intracellular enzymes and electrolytes were analyzed in an unstimulated saliva of subjects with AP, before and after the therapy and in saliva of the control group. The analysis of biochemical markers was carried out using kinetic methods with commercial reagents. Results. Concentrations of the biochemical markers AST (28.18 ? 25.16), ALT (5.48 ? 5.14), ALP (31.13 ? 37.79), ACP (17.53 ? 14.77), calcium (2.80 ? 1.97), phosphate (4.43 ? 1.92) in the saliva of subjects of the experimental group were statistically significantly higher in relation to the control group (p = 0.000; p = 0.001). Significant correlation was found between AST values, debris index (? = -0.444; p = 0.026) and calculus index (? = -0.513; p = 0.009), and between the plaque index and ALP level in the saliva after therapy (p = 0.020). Conclusion. The investigation will contribute to a better understanding and standardization of biomarkers in the saliva that mayhelp in diagnosing the AP and evaluation of the applied therapy.

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Section: Discussionsupporting

confidence: 81%

“…In our study, statistically significantly higher ALP values were measured in the group of subjects with AP compared to those with a healthy periodontium. Also, compared to healthy subjects, the level of ALP in the saliva [22,23] and gingival fluid [24] was increased in patients with chronic periodontitis.…”

Section: Discussionmentioning

confidence: 89%

Analysis of biochemical markers in the saliva and correlation with clinical parameters in patients with aggressive periodontitis, before and after the therapy

et al. 2021

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“…Twelve current studies related to local host responses in AgP were examined (Table 3). 30,[41][42][43][44][45][46][47][48][49][50][51] Of these, 9 studies 41,42,44-46,49-52 looked at multiple crevice sites within a patient population. Of these, 5 manuscripts 46,[48][49][50]52 reported multiple mediators at the local site.…”

Section: Relevant Findingsmentioning

confidence: 99%

“…Undoubtedly these cytokines could drive immune responsiveness at that site. Other more restrictive studies 44,45,51 examined individual pre-selected factors, i.e., lactic acid dehydrogenase and matrixmetalloproteinases (MMPs), and thus had a built-in bias ( Table 3).…”

Section: Relevant Findingsmentioning

confidence: 99%

Classification and diagnosis of aggressive periodontitis

Fine

Patil

Loos

2018

J Clinic Periodontology

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Conflicting data resulted for several reasons; 1) the classification was too broad, 2) the disease (AgP) was not studied from its inception, at differing time points (temporal), and at different locations (topographic). New technologic advances coupled with a more delimiting definition of disease will allow for genetic, host and microbial factor analyses in an unbiased manner. As such we predict that progress can be made in identifying a robust group of genetic, host, and microbial risk-markers associated with periodontal disease that can improve diagnostic capability in disease associated with juveniles, adolescents, and post-adolescent individuals.

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“…Undoubtedly these cytokines could drive immune responsiveness at that site. Other more restrictive studies examined individual pre‐selected factors, i.e., lactic acid dehydrogenase and matrixmetalloproteinases (MMPs), and thus had a built‐in bias (Table ).…”

Section: Literature Reviewmentioning

confidence: 99%