Intradiscal Injection of Hematopoietic Stem Cells in an Attempt to Rejuvenate the Intervertebral Discs

Haufe, Scott M.W.; Mork, Anthony R.

doi:10.1089/scd.2006.15.136

Cited by 102 publications

(99 citation statements)

References 5 publications

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“…Similar outcomes were found in a different study where two patients with disc degeneration experienced pain relief and increase in water content of the disc at 2 years after injection of autologous MSCs (97). In another study, 10 patients who underwent intradiscal injection of hematopoietic precursor stem cells obtained from their pelvic bone marrow experienced no clinical improvement of their discogenic low back pain after 1 year (98).…”

Section: Cell Replacementsupporting

confidence: 77%

Biologic Treatment of Mild and Moderate Intervertebral Disc Degeneration

Vasiliadis

Pneumaticos

Evangelopoulos

et al. 2014

Mol Med

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Disc degeneration is the most common cause of back pain in adults and has enormous socioeconomic implications. Conservative management is ineffective in most cases, and results of surgical treatment have not yet reached desirable standards. Biologic treatment options are an alternative to the above conventional management and have become very attractive in recent years. The present review highlights the currently available biologic treatment options in mild and moderate disc degeneration, where a potential for regeneration still exists. Biologic treatment options include protein-based and cell-based therapies. Proteinbased therapies involve administration of biologic factors into the intervertebral disc to enhance matrix synthesis, delay degeneration or impede inflammation. These factors can be delivered by an intradiscal injection, alone or in combination with cells or tissue scaffolds and by gene therapy. Cell-based therapies comprise treatment strategies that aim to either replace necrotic or apoptotic cells, or minimize cell death. Cell-based therapies are more appropriate in moderate stages of degenerated disc disease, when cell population is diminished; therefore, the effect of administration of growth factors would be insufficient. Although clinical application of biologic treatments is far from being an everyday practice, the existing studies demonstrate promising results that will allow the future design of more sophisticated methods of biologic intervention to treat intervertebral disc degeneration.

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Section: Cell Replacementsupporting

confidence: 77%

Biologic Treatment of Mild and Moderate Intervertebral Disc Degeneration

Vasiliadis

Pneumaticos

Evangelopoulos

et al. 2014

Mol Med

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“…Another study involved intradiscal injection of hematopoietic stem cells into ten patients that had confirmed disc pain and these patients' pain was assessed at 6-month and 12-month intervals. In contrast to previous study, none of these individuals had any relief of symptoms (Haufe et al, 2006). These trials suggest that stem cells have the potential to relieve symptoms of DDD and restore normal IVD anatomy; however, more human studies are needed to truly establish this.…”

Section: Human Studiescontrasting

confidence: 76%

Stem Cell-Mediated Intervertebral Disc Regeneration

Hussain¹,

Tejwani²,

Perez-Cruet³

2012

Tissue Regeneration - From Basic Biology to Clinical Application

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“…Several cell-based therapies to stimulate IVD regeneration have been proposed in recent years: haematopoietic stem cells (HSC) [186], fetal spine cells [187], immortalized NP-cell lines [188], autologous IVD chondrocytes [189], embryonic stem cells (SC) [190], induced pluripotent SC [191], olfactory SC [192] and MSCs (derived either from bone marrow [193] or from umbilical cord blood [194]) have all been suggested to have potential for IVD repair/regeneration. NP progenitor cells were isolated from the NP (with approximately 1% frequency) and differentiated into chondrogenic and neurogenic lineages, suggesting potential for IVD regeneration [195].…”

Section: Cell-based Therapiesmentioning

confidence: 99%

Inflammation in intervertebral disc degeneration and regeneration

Molinos

Almeida

Caldeira

et al. 2015

J. R. Soc. Interface.

336

256

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Intervertebral disc (IVD) degeneration is one of the major causes of low back pain, a problem with a heavy economic burden, which has been increasing in prevalence as populations age. Deeper knowledge of the complex spatial and temporal orchestration of cellular interactions and extracellular matrix remodelling is critical to improve current IVD therapies, which have so far proved unsatisfactory. Inflammation has been correlated with degenerative disc disease but its role in discogenic pain and hernia regression remains controversial. The inflammatory response may be involved in the onset of disease, but it is also crucial in maintaining tissue homeostasis. Furthermore, if properly balanced it may contribute to tissue repair/regeneration as has already been demonstrated in other tissues. In this review, we focus on how inflammation has been associated with IVD degeneration by describing observational and in vitro studies as well as in vivo animal models. Finally, we provide an overview of IVD regenerative therapies that target key inflammatory players.

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Intradiscal Injection of Hematopoietic Stem Cells in an Attempt to Rejuvenate the Intervertebral Discs

Cited by 102 publications

References 5 publications

Biologic Treatment of Mild and Moderate Intervertebral Disc Degeneration

Biologic Treatment of Mild and Moderate Intervertebral Disc Degeneration

Stem Cell-Mediated Intervertebral Disc Regeneration

Inflammation in intervertebral disc degeneration and regeneration

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