Intraductal carcinoma of the prostate: interobserver reproducibility survey of 39 urologic pathologists

Iczkowski, Kenneth A.; Egevad, Lars; Ma, Jun; Harding-Jackson, Nicholas; Algaba, Ferrán; Billis, Athanase; Camparo, Philippe; Liu, Cheng; Clouston, David; Compérat, Éva; Datta, Milton W.; Evans, Andrew; Griffiths, David; Guo, Charles C.; Hailemariam, Seife; Huang, Wei; Humphrey, Peter A.; Jiang, Zhong; Kahane, Hillel; Kristiansen, Glen; Rosa, Francisco G. La; López-Beltrán, Antonio; MacLennan, Gregory T.; Magi‐Galluzzi, Cristina; Merrimen, Jennifer; Montironi, Rodolfo; Osunkoya, Adeboye O.; Picken, Maria M.; Rao, Nagarjun; Shah, Rajal B.; Shanks, Jonathan H; Shen, Steven S.; Tawfik, Ossama; True, Lawrence D.; Kwast, Theodorus H. van der; Varma, Murali; Wheeler, Thomas M.; Zynger, Debra L.; Sahr, Natasha; Bostwick, David G.

doi:10.1016/j.anndiagpath.2014.08.010

Cited by 39 publications

(37 citation statements)

References 29 publications

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“…They therefore represent robust morphological biomarkers of aggressive prostate cancer, with few false positive diagnoses. This is in keeping with the few interobserver studies focused on IDC and CC in prostatectomy‐derived samples, showing that pathologists attained good agreement for the diagnosis of both IDC and CC . Indeed, among the various architectural patterns constituting Gleason grade 4, including ill‐formed, fused and glomeruloid pattern, CC scored highest.…”

Section: Discussionsupporting

confidence: 80%

Concordance of biopsy and prostatectomy diagnosis of intraductal and cribriform carcinoma in a prospectively collected data set

et al. 2018

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Section: Discussionsupporting

confidence: 80%

Concordance of biopsy and prostatectomy diagnosis of intraductal and cribriform carcinoma in a prospectively collected data set

et al. 2018

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“…Iczkowski et al demonstrated significant interobserver variation with only 43% agreement in the diagnosis of IDC-P 11. In that study, the lead authors circulated photomicrographs to 39 uropathologists and interpreted from their responses which criteria had been used to render a diagnosis of IDC-P.…”

Section: Discussionmentioning

confidence: 99%

“…A recent study using photomicrographs found significant variation in the diagnosis of IDC-P among expert uropathologists 11. However, it is unclear whether this was due to the inevitable variation in interpreting borderline cases, use of different diagnostic criteria or a combination of both.…”

Section: Introductionmentioning

confidence: 99%

Intraductal carcinoma of prostate reporting practice: a survey of expert European uropathologists

et al. 2016

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“…Future studies are required to further validate the clinical utility and functional relevance of DNA methylation events in cribriform and IDC architecture, and whether it should be routinely included in the RP pathology reports. Due to the challenges in the unequivocal identification of these clinicopathological entities by certain pathologists, the evaluation of these morphological features must be incorporated in the rapidly developing field of digitized histopathology (18,19,34). This may provide clinically translatable imaging markers for PCa prognosis.…”

Section: Median Pmr Values ------------------------------------------mentioning

confidence: 99%

“…The unequivocal identification of these pathological features based on the morphological criteria alone has been reported as challenging (18,19). In this regard, molecular features such as DNA methylation alterations may be of value.…”

Section: Introductionmentioning

confidence: 99%

Distinct DNA methylation alterations are associated with cribriform architecture and intraductal carcinoma in Gleason pattern 4 prostate tumors

et al. 2017

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Abstract. The aim of the present study was to explore DNA methylation aberrations in association with cribriform architecture and intraductal carcinoma (IDC) of the prostate, as there is robust evidence that these morphological features are associated with aggressive disease and have significant clinical implications. Herein, the associations of a panel of seven known prognostic DNA methylation biomarkers with cribriform and IDC features were examined in a series of 91 Gleason pattern (GP) 4 tumors derived from Gleason score 7 radical prostatectomies. Gene specific DNA methylation was compared between cribriform and/or IDC positive vs. negative cases, and in association with clinicopathological features, using Chi square and Mann-Whitney U tests. DNA methylation of the adenomatous polyposis coli, Ras association domain family member 1 and T-box 15 genes was significantly elevated in GP4 tumors with cribriform and/or IDC features compared with negative cases (P=0.045, P=0.007 and P=0.013, respectively). To the best of our knowledge, this provides the first evidence for an association between cribriform and/or IDC and methylation biomarkers, and warrants further investigation of additional DNA methylation events in association with various architectural patterns in prostate cancer. IntroductionProstate cancer (PCa) is the second most common type of cancer affecting men worldwide, with an incidence of 1.1 million new cases each year (1). The most widely accepted pathological grading of PCa is the Gleason Score (GS), which is based on architectural features of the gland and is comprised of the sum of two Gleason Patterns (GP) (2). The GS grading system is among the most effective predictors of clinical outcomes following radical prostatectomy (RP), and is universally used to guide PCa treatment (3). Within this system, GS6 PCas are low grade, whereas GS8 or higher are classified as high grade. GS7 prostate adenocarcinomas consisting of variable proportions of GP3 and GP4 are considered to be intermediate grade, and represent the most heterogeneous group of neoplasms with diverse clinical outcomes (4,5) Thus, GS7 PCa is the focus of the current study, as identifying specific prognostic factors that can provide additional information on disease progression and treatment outcomes for patients with GS7 PCa would be of marked clinical benefit. GP4 is assigned to adenocarcinomas when they contain any of the following architectural patterns: Small/large fused glands, poorly formed glands, glomeruloid and cribriform architecture (4-6). The cribriform pattern is commonly associated with intraductal carcinoma (IDC), a distinct histopathological entity characterized by malignant cells spanning the lumen of prostate ducts and acini (7-9). Although specific morphologies of PCa, including cribriform architecture and IDC, have been recognized for decades, their independent clinical significance is only now emerging (8). Studies have demonstrated that IDC in biopsy and/or RP tissues is indicative Distinct DNA methylation alteration...

show abstract

Intraductal carcinoma of the prostate: interobserver reproducibility survey of 39 urologic pathologists

Cited by 39 publications

References 29 publications

Concordance of biopsy and prostatectomy diagnosis of intraductal and cribriform carcinoma in a prospectively collected data set

Concordance of biopsy and prostatectomy diagnosis of intraductal and cribriform carcinoma in a prospectively collected data set

Intraductal carcinoma of prostate reporting practice: a survey of expert European uropathologists

Distinct DNA methylation alterations are associated with cribriform architecture and intraductal carcinoma in Gleason pattern 4 prostate tumors

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