Intraductal Carcinoma of the Prostate: A Risk for Rapid Recurrence

Dinerman, Brian; Bernstein, Adrien; Khani, Francesca; Hu, Jim C.

doi:10.1016/j.urology.2017.03.030

Cited by 6 publications

(11 citation statements)

References 10 publications

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“…control animals using our CUWR method. While repeated measurements of the same animal within a short period of time yielded similar results, especially the introduction of pBOO is known to increase variability of bladder functional parameters as well as bladder mass within the same treatment group [ 23 ]. Intra-group variability and effect size of treatment or experimental procedure, respectively, determine the number of animals needed per group to allow statistically significant detection of functional differences among groups.…”

Section: Discussionmentioning

confidence: 96%

Non-invasive voiding assessment in conscious mice

Sidler

Aitken

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et al. 2018

Bladder

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OBJECTIVE: To review available options of assessing murine bladder function and to evaluate a non-invasive technique suitable for long-term recording. METHODS: We reviewed previously described methods to record rodent bladder function. We used modified metabolic cages to capture novel recording tracings of mouse micturition. We evaluated our method in a pilot study with female mice undergoing partial bladder outlet obstruction or sham operation, respectively; half of the partial obstruction and sham group received treatment with an S6K-inhibitor, targeting the mTOR pathway, which is known to be implicated in bladder response to obstruction. RESULTS: Our non-invasive method using continuous urine weight recording reliably detected changes in murine bladder function resulting from partial bladder outlet obstruction or treatment with S6K-inhibitor. We found obstruction as well as treatment with S6K-inhibitor to correlate with a hyperactive voiding pattern. CONCLUSIONS: While invasive methods to assess murine bladder function largely disturb bladder histology and intrinsically render post-cystometry gene expression analysis of questionable value, continuous urine weight recording is a reliable, inexpensive, and critically non-invasive method to assess murine bladder function, suitable for a long-term application.

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Section: Discussionmentioning

confidence: 96%

Non-invasive voiding assessment in conscious mice

Sidler

Aitken

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et al. 2018

Bladder

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“…IDC and CC are now increasingly established as independent markers of aggressive prostate cancer when identified in prostate biopsies and prostatectomy specimens. 2,6 However, a study on the concordance of biopsy and corresponding prostatectomy diagnosis of these two clinically important features has not been reported to date. We demonstrate a near 100% specificity of the routinely reported biopsy diagnosis of IDC, using corresponding prostatectomy findings as a gold standard.…”

Section: Discussionmentioning

confidence: 99%

“…IDC and CC are now increasingly established as independent markers of aggressive prostate cancer when identified in prostate biopsies and prostatectomy specimens . However, a study on the concordance of biopsy and corresponding prostatectomy diagnosis of these two clinically important features has not been reported to date.…”

Section: Discussionmentioning

confidence: 99%

“…5 Moreover, both in prostate biopsy and radical prostatectomy specimens, its presence is a strong and independent prognosticator of metastatic disease and death of disease. [6][7][8] Further, its presence in biopsies was shown to be associated with more advanced pathological stage at the time of prostatectomy. 9,10 Several studies now combine IDC and CC as a single biomarker for poor prognosis 2 and as a marker for genetic instability.…”

Section: Introductionmentioning

confidence: 97%

“…Now, it is well established that IDC represents a histopathological entity associated with higher Gleason score and advanced pathological stage . Moreover, both in prostate biopsy and radical prostatectomy specimens, its presence is a strong and independent prognosticator of metastatic disease and death of disease . Further, its presence in biopsies was shown to be associated with more advanced pathological stage at the time of prostatectomy .…”

Section: Introductionmentioning

confidence: 97%

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Concordance of biopsy and prostatectomy diagnosis of intraductal and cribriform carcinoma in a prospectively collected data set

et al. 2018

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Is cancer biology different in older patients?

Herck

Feyaerts

Alibhai

et al. 2021

The Lancet Healthy Longevity

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Roughly 50% of cancer cases occur in people aged 65 years or older. Older people are often diagnosed at a later stage and might receive less (intensive) treatment, which might affect the outcome. In addition, an older age might be associated with biological differences in tumour and microenvironment behaviour, a domain that has been poorly studied so far. In this narrative Review of published literature, we explored the reported differences in tumour biology according to age in five major cancer types: breast, colorectal, prostate, lung, and melanoma. Our literature search uncovered clear differences in tumour histology and subtype distribution in older people compared with younger patients, as well as age-specific patterns of tumour mutations and other molecular alterations. Several studies also indicate notable changes in tumour-infiltrating immune cells in tumours of older versus younger people, although this research is still in its infancy. More research is needed and might lead to a better understanding of the biology of ageing in relation to malignancy. This knowledge could provide new perspectives for more personalised cancer treatments, eventually improving the global outcomes of older patients with cancer.

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Intraductal Carcinoma of the Prostate: A Risk for Rapid Recurrence

Cited by 6 publications

References 10 publications

Non-invasive voiding assessment in conscious mice

Non-invasive voiding assessment in conscious mice

Concordance of biopsy and prostatectomy diagnosis of intraductal and cribriform carcinoma in a prospectively collected data set

Is cancer biology different in older patients?

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