Intraductal Papillary Neoplasms of the Pancreas: Diagnosis by Endoscopic Pancreatic Biopsy

Abstract

Intraductal papillary neoplasms of the pancreas (IPN) are rare tumors, distinct from other pancreatic duct cell carcinomas both in terms of papillary polyp formation in the main pancreatic duct and their favorable prognosis. In the present study, endoscopic pancreatic biopsy (EPB) under fluoroscopic control was employed in three cases of IPN to obtain a tissue diagnosis prior to surgery. There were no complications and all biopsy specimens were adequate for histopathological evaluation. In our experience, EPB is a simple, safe and effective method, yielding sufficient material for preoperative tissue diagnosis of pancreatic tumors, especially in the case of IPN.

Positron emission tomography with 2-deoxy-2-[ 18 F] fluoro-d-glucose for diagnosis of intraductal papillary mucinous tumor of the pancreas with parenchymal invasion

“…5 Determination of the malignancy grade is difficult even with biopsy specimens obtained directly from the tumor, because of histological heterogeneity. 6 Several investigators have insisted that IPMT can be categorized into two subtypes, depending upon which part of the pancreatic duct is involved. 7,8 That is, in comparison to tumor involving the branches, tumor involving the main duct is usually associated with greater progression of histological features.…”

Mucin-producing tumors of the pancreas: clinicopathological features, surgical treatment, and outcome

“…Other investigators have attempted to preoperatively differentiate benign from borderline/malignant MPT 22. Unfortunately, malignancy was often not clearly defined preoperatively and the diagnosis may have been based only on the degree of cytological atypia 12,23. We decided that surgery was indicated for MPTs with the following features: (1) main pancreatic duct >7 mm in diameter, (2) a cystic lesion >25 mm in diameter, and (3) a nodule in a cystic lesion >6 mm in diameter 23.…”

“…Mucin‐producing tumors (MPTs) of the pancreas have unique clinical features distinct from those of “common pancreatic ductal cell carcinoma”, and patients have a relatively good prognosis after surgical removal . It is possible that MPTs are being increasingly recognized because of the more frequent use of computed tomography (CT), ultrasonography (US), and endoscopic retrograde cholangiopancreatography (ERCP) 12,13. This disease is known by a variety of names which have been summarized elsewhere 14,15.…”

Immunocytochemical detection of p53 protein as an adjunct in cytologic diagnosis from pancreatic duct brushings in mucin‐producing tumors of the pancreas

“…19 However, it is hard to push the biopsy catheter into the target showed nuclear accumulation of p53 protein. 19 However, it is hard to push the biopsy catheter into the target showed nuclear accumulation of p53 protein.…”