Intraepidermal Glandular Carcinoma of the Nipple (Mammary Paget-like Disease) in 2 Dogs

Ramı́rez, G.A.; Suárez‐Bonnet, Alejandro; Altimira, J.; Espinosa-de-los-Monteros, Antonio; Garcia-Gonzalez, Beatriz; Vilafranca, M.

doi:10.1177/0300985811414030

Cited by 4 publications

(4 citation statements)

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“…The gross lesions had features that could be associated with Paget-like disease (ie, crusting and pigmentary changes) and scattered cells with clear cytoplasmic vacuoles ("signet ring" cells) can be a feature of Paget-like disease. 13 However, other features of Paget-like disease were not present in this study, including individual and small clusters of carcinoma cells in the epidermis of the teat 13 and underlying mammary carcinoma. 13 The presence of multiple teat lesions in some cases also helped to rule out Paget-like disease.…”

Section: Discussionmentioning

confidence: 52%

“…13 However, other features of Paget-like disease were not present in this study, including individual and small clusters of carcinoma cells in the epidermis of the teat 13 and underlying mammary carcinoma. 13 The presence of multiple teat lesions in some cases also helped to rule out Paget-like disease.…”

Section: Discussionmentioning

confidence: 52%

“…18 The literature on proliferative lesions of the canine teat is sparse. Reported lesions include melanosis of the skin of the teat, teat hyperplasia, ductal adenoma, intraductal papillary adenoma, ductal carcinoma, intraductal papillary carcinoma, carcinoma with epidermal infiltration (Paget-like disease), 5,13,18 and a single case of smooth muscle hamartoma of the nipple. 3 To the best of our knowledge, ostensibly non-neoplastic epithelial proliferative lesions of the teat ducts and sinuses have not been reported.…”

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confidence: 99%

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Teat sinus and duct adenomatous hyperplasia in dogs

Schulman

Goldschmidt

Hardcastle³

et al. 2021

Vet Pathol

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Seventeen lesions diagnosed as teat sinus and duct adenomatous hyperplasia were identified in 10 dogs. All of the dogs were small breeds. Six were spayed female and 4 were male, 3 castrated and 1 intact. In 5 cases, the lesions involved multiple teats. They were pink to black, flattened to round, and sometimes crusted. Histologically, the lesions were usually pigmented (16/17), plaque-like to nodular masses composed of polygonal cells arranged in anastomosing trabeculae and bilayered ducts and/or cysts, with a fibrous to mucinous (Alcian blue-positive) stroma and squamous cysts (12/17). Scattered epithelial cells contained single, discrete, clear cytoplasmic vacuoles. Atypia was mild, and the mitotic count per 2.37 mm2 varied from 0 to 15 (average 2.7). Immunohistochemistry was performed on 14 of the lesions from 8 dogs. Epithelial cells were 100% panCK+ and included basally located CK14+/CK5_6+/p63+/calponin− cells and nonbasal CK19+/CK7+ cells. Cells manifesting squamous differentiation were usually panCK+/CK14+/CK5_6+/CK19−/CK7−/p63±/calponin−. In addition to fibroblasts, vimentin positivity was found in disseminated, round to stellate stromal and intraepithelial cells that often had black, granular, cytoplasmic pigment (consistent with dendritic/phagocytic cells and/or melanocytes). Of the 8 dogs for which clinical follow-up information was available, all were still alive and well, with no significant teat changes, development of mammary lesions or other masses 4 to 22 months (median 12.5) after biopsy. The histologic, immunohistochemical, and clinical findings were consistent with teat duct and sinus adenomatous hyperplasia. This is an uncommon, benign proliferative lesion that can involve multiple teats of female and male, small breed dogs.

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Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 52%

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confidence: 99%

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Teat sinus and duct adenomatous hyperplasia in dogs

Schulman

Goldschmidt

Hardcastle³

et al. 2021

Vet Pathol

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“…It is interesting that among the described cases of male MGTs, 15 out of 74 (20.2%) were diagnosed in Crossbreeds (Arias et al 2015 ; Gopal et al 2022 ; Maiti et al 2014 ; Silva et al 2019 ) followed by Cocker Spaniels (18.9%) (Bearss et al 2012 ; Han et al 2016 ; Kwon et al 2017 ; Maiti et al 2014 ), German Shepherds (10.8%) (Machado et al 2020 ; Maiti et al 2014 ; Veena et al 2012 ), Labrador Retrievers (6.7%) (Bearss et al 2012 ; Lather et al 2017 ; Saba et al 2007 ) and Rottweilers (6.7%) (Machado et al 2020 ; Mamom et al 2012 ; Ramírez et al 2011 ; Saba et al 2007 ). Moreover, previous literature data indicated that Cocker Spaniels may be overrepresented among male dogs with MGTs (Bearss et al 2012 ).…”

Section: Mammary Gland Tumours In Male Dogsmentioning

confidence: 99%

Occurrence of mammary gland tumours in male dogs and its weak association with development of testicular tumours: a review

Tkaczyk-Wlizło,

Kowal,

Śmiech

et al. 2023

J Appl Genetics

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Mammary gland tumours (MGTs) are commonly occurring neoplasms in female dogs. However, rare cases of MGTs in male dogs have been reported for years. Due to the low incidence of MGTs in male dogs in comparison to female dogs, veterinary oncology is mainly focused on mammary neoplasms diagnosed in female dogs and extensive research is conducted in this scientific area. Therefore, there are no sufficient epidemiological data on male dogs and the aetiology of their tumour development is still poorly understood.The aim of this literature review was to present cases of MGTs in male dogs for better understanding the scale of the problem over the years. The analyses of 74 affected male dogs with 92 tumours showed that the majority of MGTs in male dogs were benign tumours (54.3%), especially in form of adenomas, often developed in posterior canine mammary glands (58.1%).The increased number of canine MGTs in male dogs aged 7 -13 years with an age peak at 11 years was noted. The age of affected animals was not related to breed. Mammary gland neoplasms were diagnosed predominately in Crossbreeds (20.2%) followed by Cocker Spaniels (18.9%) and German Shepherds (10.8%).The association between MGT development in male dogs and co-occurrence of testicular tumours (TTs) has been discussed for years. Thus, cases of development of both tumours were included in this study. As a result, only in 12.7% cases of MGTs also history of TTs was described. Therefore, no general association between these tumours should be assumed.

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