Tumors of the Mammary Gland

Goldschmidt, Michael H.; Peña, Laura; Zappulli, Valentina

doi:10.1002/9781119181200.ch17

Cited by 100 publications

(186 citation statements)

References 162 publications

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“…Sendo o nódulo localizado em região de mama, podendo se diagnosticar o nódulo na punção citológica como um carcinoma mamário. Os carcinomas mamários são neoplasias extremamente comuns nas cadelas, havendo também uma relação direta do aparecimento desse tumor com a castração desses animais, e com a idade em que este procedimento foi realizado (GOLDSHMIDT, 2017).…”

Section: Resultsunclassified

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Sarcoma Histiocítico Com Múltiplas Localizações Em Um Cão

Oliveira¹,

Modesto²,

Dias³

et al. 2018

Enci Bio

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RESUMOAs doenças proliferativas histiocíticas são desordens conhecidas no cão e que possuem inúmeras origens, muitas ainda não completamente elucidadas. O complexo sarcoma histiocítico pode ser dividido em três principais tipos: sarcoma histiocítico localizado, sarcoma histiocítico disseminado e sarcoma histiocítico hemofagocítico. O objetivo desse trabalho foi relatar um caso de sarcoma histiocítico disseminado acometendo múltiplas localizações em um Rotweiler. O animal foi atendido pelo Hospital Veterinário da Universidade Federal de Uberlândia (HV-UFU) com a queixa de um aumento de volume em membro posterior esquerdo e presença de uma massa em placa na região de glândulas mamárias torácica caudal à inguinal esquerda. Foi realizada a punção aspirativa por agulha fina da massa e obteve-se o diagnóstico de sarcoma histiocítico. Após dois dias de piora clínica o animal foi eutanasiado e então o Laboratório de Patologia Animal do HV-UFU realizou o exame de necropsia. Ao realizar o exame foi observada linfadenomegalia em linfonodos axilar e inguinal esquerdos, e a presença de uma massa aderida à parede dorsal de cavidade abdominal. Os órgãos alterados foram coletados e após realização de exame histopatológico foi confirmado o diagnóstico de sarcoma histiocítico com metástase para linfonodo axilar e inguinal esquerdos. PALAVRAS-CHAVE: citopatológico, complexo sarcoma histiocítico, neoplasma, metástase.

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Section: Resultsunclassified

“…Devido à maior frequência do aparecimento do tumor em região de glândula mamária serem diagnosticados como neoplasmas mamários, principalmente em cadelas adultas a idosas (GOLDSHMIDT et al, 2017), a massa encontrada no cão do presente relato pode ter sido diagnosticada no exame citológico erroneamente como carcinoma mamário.…”

Section: Resultsunclassified

Sarcoma Histiocítico Com Múltiplas Localizações Em Um Cão

Oliveira¹,

Modesto²,

Dias³

et al. 2018

Enci Bio

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“…The diagnosis of tubulopapillary carcinoma of the mammary gland in a mare was based on the clinical-pathological and immunohistochemical findings. Contrary to what occurs in bitches [4], breast neoplasms are uncommon in herbivores [5,9,10]. In a study carried out in slaughterhouses in France, with approximately 40,000 horses slaughtered, only 45 breast neoplasms (0.11%) were observed, most of them consisting of carcinomas [9,10].…”

Section: Discussionmentioning

confidence: 99%

“…In mares with neoplasia of the mammary gland, unilateral or bilateral volume increase, pain, warm area, redness and suppurative serous discharge are frequently observed [13]. There are also reports of skin ulceration or necrosis [4]. Necrosis would be an impor-tant clinical feature to aid in the diagnosis of mammary neoplasia [10], especially in cases of adenocarcinomas [3].…”

Section: Discussionmentioning

confidence: 99%

Tubulopapillary Carcinoma of the Mammary Gland in a Mare

Júnior

Pavarini

Santos

et al. 2019

Acta Scientiae. Vet.

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Background: Mammary gland neoplasia are often observed in bitches and cats, rarely in cows, goats, sheep, sows, and mares. Among the neoplasia that affect mares, breast tumors are rare, as they occur more frequently in older animals. In horses, mammary gland tumors occur more frequently in older animals. In this species there are reports of cases describing carcinomas and adenocarcinomas and several subtypes. Mammary neoplasms in equines tend to be locally aggressive and promote metastases to the regional lymph nodes and other organs, including the lungs, and may cause pleural effusion. The aim objective of the present case report was to describe the clinical-pathological and immunohistochemical findings of a tubulopapillary carcinoma of the mammary gland in mare. Case: Was received a biopsy of a tumor mass of the mammary gland of a 15-year-old Quarter Horse mare. According to the veterinarian, the mare presented an increase in volume with ulceration of the mammary gland three months before the biopsy. Macroscopically, the mass was firm to the cut with white surface measuring 12x12 cm. The fragment was fixed in 10% formalin, routinely processed for histology, paraffin embedded, and stained with hematoxylin and eosin. Microscopically, we observed proliferation of epithelial neoplastic cells arranged in tubules and papillary projections, some with two to three layers of cells. Neoplastic cells had oval, moderate and distinct cytoplasm. The nuclei were rounded with dense chromatin and an apparent nucleolus. There were two figures of mitosis per field of high magnification. Proliferation of neoplastic cells invaded adjacent tissues, and in lymph vessels of the region, neoplastic cells were observed as well as inflammation in adjacent tissue. In addition, the breast fragment was submitted to the immunohistochemistry technique using anti-pancytokeratin and anti-vimentin antibody. In immunohistochemistry for pancytokeratin, there was immunoreactivity with marked cytoplasm in neoplastic epithelial cells. In immunohistochemistry for vimentin, there was cytoplasmic labeling in cells of the supporting tissue (fibroblasts and endothelial cells). After approximately six months of the initial diagnosis, the mare died. Discussion: The diagnosis of tubulopapillary carcinoma of the mammary gland in a mare was based on the clinicalpathological and immunohistochemical findings. In mares, descriptions of breasts neoplasia are uncommon and found in animals aged over 12 years. In a study carried out in slaughterhouses in France, with approximately 40,000 horses slaughtered, only 45 breast neoplasms (0.11%) were observed, most of them consisting of carcinomas. In these equines, the absolute incidence of neoplasia of the reproductive system increases with age and tumors generally appear as deep, multifocal, and ulcerating skin nodules. Thus, important differential diagnoses include chronic mastitis and prepartum breast edema. In mares with neoplasia of the mammary gland, unilateral or bilateral volume increase, pain, warm area, redness ...

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“…Spontaneously occurring canine mammary gland tumors (CMTs) are the most common tumor type in intact female dogs [1,2]. CMTs in dogs share many epidemiological, biological, and clinical features with human breast cancer including their biological behavior and histologic features [3].…”

Section: Introductionmentioning

confidence: 99%

Quantitative analysis of HER2 mRNA expression by RNA in situ hybridization in canine mammary gland tumors: Comparison with immunohistochemistry analysis

et al. 2020

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Spontaneously occurring canine mammary gland tumors share many features with human breast cancer, including biological behavior and histologic features. Compared to transgenic murine model, canine models have advantages including naturally occurring models of human diseases and cancer. In humans, breast cancer is divided into molecular subtypes based on ER, PR, and HER2 expression. In contrast with humans, few studies have evaluated these subtypes in canine mammary gland tumors, including expression of HER2. HER2 expression in canine mammary tissues has been further complicated by controversy regarding the antibody's specificity. This study aimed to investigate c-erbB2 mRNA expression in retrospective formalin-fixed paraffin embedded samples, using RNA in situ hybridization with a novel quantitative assay and to compare this method with immunohistochemistry. Using 48 canine mammary tumor samples and 14 non-neoplastic canine mammary tissues, RNA in situ hybridization was performed with RNAscope ® using a canine-specific target gene probe (ERBB2), and quantitative measurement was performed using the housekeeping gene (POLR2A) to calculate the target gene/housekeeping gene ratio. The ratio of ERBB2/POLR2A was quantified using open-source image analysis programs and compared with the immunohistochemistry results. A significant correlation was observed between the HER2 immunohistochemistry score and ERBB2/ POLR2A RNA in situ hybridization (P < 0.001). When the HER2 immunohistochemistry score was 3+, significantly higher expression of HER2 mRNA was observed by RNA in situ hybridization. Interestingly, HER2 mRNA was also observed in non-neoplastic mammary tissues by RNA in situ hybridization. This assay potentially facilitates the reliable quantification of mRNA expression levels in retrospective formalin-fixed paraffin-embedded samples. Further studies are required to elucidate the role of HER2 in canine mammary gland tumors and to implement clinical trials in dogs. Case selection and histopathological analysisForty-eight CMT samples and 14 non-neoplastic canine mammary tissue samples that were suspected tumors but diagnosed as mammary gland hyperplasia were selected from the archived FFPE database from 2017 to 2019 at the Department of Veterinary Pathology, Konkuk University. Simple random sampling was performed for CMT samples yielding HER2 IHC data (available from our previous data descriptor [21] and validation studies) with complete clinical data. During RNA-ISH, tissue samples not suitable for analysis were excluded Quantitative analysis of mRNA levels by RNA in situ hybridization in formalin-fixed paraffin-embedded samples PLOS ONE | https://doi.org/10.Quantitative analysis of mRNA levels by RNA in situ hybridization in formalin-fixed paraffin-embedded samples PLOS ONE | https://doi.

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Tumors of the Mammary Gland

Cited by 100 publications

References 162 publications

Sarcoma Histiocítico Com Múltiplas Localizações Em Um Cão

Sarcoma Histiocítico Com Múltiplas Localizações Em Um Cão

Tubulopapillary Carcinoma of the Mammary Gland in a Mare

Quantitative analysis of HER2 mRNA expression by RNA in situ hybridization in canine mammary gland tumors: Comparison with immunohistochemistry analysis

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