Intrafamilial Clustering of<i>Helicobacter pylori</i>Infection

Drumm, Brendan; Perez-Perez, Guillermo I.; Blaser, Martin J.; Sherman, Philip M.

doi:10.1056/nejm199002083220603

Cited by 541 publications

(288 citation statements)

References 29 publications

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“…27) Studies to date have also indicated that H. pylori, in common with nearly all infections, is established during childhood, 8) is more frequent in developing countries than in industrialized countries, 28) is inversely proportional to socioeconomic level, 6) and shows a high rate of intra-familial infection. 29) As Japan has no significant variations in ethnicity, and there is no apparent class system, the focus of our study has been how sanitation and living conditions during childhood might have affected H. pylori infection. Thus, the questionnaire content was predicated on the subject's living conditions at age 10 and was designed to address issues of drinking water, availability of flush toilets, residential area, family size, nursing and birth order.…”

Section: Discussionmentioning

confidence: 99%

Helicobacter pylori risk associated with childhood home environment

Ueda

Kikuchi

Kasugai³

et al. 2003

Cancer Science

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Helicobacter pylori (H. pylori) is considered to be a cause of gastric ulcer, gastric cancer and other diseases. The relationship between infection and the hygiene or housing circumstances of such patients in their childhood was explored. The study subjects were those who applied for a H. pylori antibody test, and were asked to fill out a questionnaire enclosed with a test kit, inquiring as to their hygiene and housing conditions when they were 10 years old. Of 5971 applicants, 5854 agreed to participate in the study. Associations between the six factors in the questionnaire and infection were calculated, and adjusted for sex, age and district. Drinking water, type of toilet, residential area, number of people in the house, and birth order showed significant correlations with H. pylori infection. The odds ratios (95% confidence intervals) were 0. elicobacter pylori (H. pylori) is frequently isolated from the gastric mucosa of patients with gastric ulcer, duodenal ulcer, and chronic gastritis. Persistent H. pylori infection leads to atrophy of the gastric mucosa, causes intestinal metaplasia, and also contributes to the onset of stomach cancer. 1-3)Numerous studies so far have suggested that H. pylori infection is related to factors such as the sanitary condition of tap and ground water, 4, 5) economic status, and ethnicity. 6, 7) H. pylori infection during adulthood is believed to be rare, and infection is often established during childhood. 8,9) The aim of this study was to assess the relationship between the establishment of infection and factors such as sanitary conditions or home environment during childhood. Relevant factors were the types of water supply and toilet, residential area, family size, breastfeeding and birth order. Subjects and MethodsSubjects were selected from those who underwent both a serum PG test and an H. pylori antibody test as part of a the so-called stomach cancer examination system by mail.A questionnaire was sent out with the application form. Of the 5971 subjects who responded, 5854 consented to participate in the research, and the results of their H. pylori antibody tests were collected.The H. pylori antibody was measured using dried blood on filter paper and delivery was by the Japanese postal service. The test system itself has been administered by the Aichi Medical Foundation of Diagnostic Technology since 1995.The questionnaire inquired about the environment of the subject at the age of 10 years, eliciting details about drinking water (natural/well/tap water), type of toilet (flush/other), residential area (rural/urban), family size (1-3/4-6/7 or more), birth order (1/2-3/4-5/6 or more) and breast feeding (breast milk/ other).Multiple logistic regression models were used to calculate odds ratios (ORs) of the factors. H. pylori infection (infected or not infected) was the criterion variable, and ORs of the factors adjusted for sex, age and district were calculated.In the next step, statistically significant factors were entered into a multiple logistic regression model together...

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Section: Discussionmentioning

confidence: 99%

Helicobacter pylori risk associated with childhood home environment

Ueda

Kikuchi

Kasugai³

et al. 2003

Cancer Science

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“…8,27,30,78,94 Rothenbacher et al 119 estudaram a prevalência do H. pylori em 1.143 crianças e seus respectivos acompanhantes (n=1.074) mediante teste respiratório com C 13 -uréia. Os autores concluíram que pais infectados, especialmente as mães, podem desempenhar importante papel na transmissão do H. pylori entre familiares, à semelhança do que se observa em relação a outras bactérias da cavidade oral, como é o caso do Streptococcus mutans.…”

Section: Unidade Familiarunclassified

Aspectos epidemiológicos do Helicobacter pylori na infância e adolescência

2002

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Descritores ResumoRealizou-se revisão da epidemiologia da infecção pelo Helicobacter pylori, com o objetivo de analisar sua importância na infância e adolescência no que se refere à incidência, à prevalência, às vias de transmissão e aos fatores de risco. Para tanto, realizou-se uma pesquisa nas bases de dados Lilacs (OPS/Bireme) e Medline (National Library of Medicine) e no banco de teses da Universidade de São Paulo dos anos de 1983 a 1999. A análise da literatura levou à conclusão de que a infecção pelo Helicobacter pylori é adquirida principalmente durante a infância, apresenta aumento da prevalência com a idade, os principais fatores de riscos estão relacionados ao baixo nível socioeconômico e o mecanismo de transmissão permanece desconhecido. AbstractThe scope of the review is to study the epidemiological aspects of Helicobacter pylori infection and its importance during childhood and adolescence, focusing on incidence, prevalence, transmission and risk factors. The study's references included the following databases: LILACS (PAHO/ Bireme), MEDLINE, the US's National Library of Medicine and the thesis developed at University of São Paulo for the period 1983 to 1999. It was noted that Helicobacter pylori infection is mainly acquired during childhood, age-related prevalence, main risk factors are associated to low socioeconomic status, and its transmission mechanism remains unclear.

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“…pylori are highly genetically diverse, providing Ϸ1,400 informative sites within 4.5 kb of sequence, and their global genetic structure parallels that of humans (28). Moreover, epidemiological studies have shown that transmission occurs predominantly within families (29)(30)(31)(32). This point is critical because vertical transmission is more likely to reflect human migrations than is the horizontal transmission that is typical of many microbes.…”

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confidence: 99%

Distinguishing human ethnic groups by means of sequences from Helicobacter pylori : Lessons from Ladakh

Wirth

Wang

Linz

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

142

138

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The history of mankind remains one of the most challenging fields of study. However, the emergence of anatomically modern humans has been so recent that only a few genetically informative polymorphisms have accumulated. Here, we show that DNA sequences from Helicobacter pylori, a bacterium that colonizes the stomachs of most humans and is usually transmitted within families, can distinguish between closely related human populations and are superior in this respect to classical human genetic markers. H. pylori from Buddhists and Muslims, the two major ethnic communities in Ladakh (India), differ in their population-genetic structure. Moreover, the prokaryotic diversity is consistent with the Buddhists having arisen from an introgression of Tibetan speakers into an ancient Ladakhi population. H. pylori from Muslims contain a much stronger ancestral Ladakhi component, except for several isolates with an Indo-European signature, probably reflecting genetic flux from the Near East. These signatures in H. pylori sequences are congruent with the recent history of population movements in Ladakh, whereas similar signatures in human microsatellites or mtDNA were only marginally significant. H. pylori sequence analysis has the potential to become an important tool for unraveling short-term genetic changes in human populations.mtDNA ͉ microsatellites ͉ admixture ͉ human migrations ͉ population genetics

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Intrafamilial Clustering ofHelicobacter pyloriInfection

Cited by 541 publications

References 29 publications

Helicobacter pylori risk associated with childhood home environment

Helicobacter pylori risk associated with childhood home environment

Aspectos epidemiológicos do Helicobacter pylori na infância e adolescência

Distinguishing human ethnic groups by means of sequences from Helicobacter pylori : Lessons from Ladakh

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