Intrafractional Baseline Shift or Drift of Lung Tumor Motion During Gated Radiation Therapy With a Real-Time Tumor-Tracking System

Sugiyama, Takao; Miyamoto, Naoki; Matsuura, Tetsuya; Onimaru, Rikiya; Katoh, Norio; Inoue, Tetsuya; Sutherland, Kenneth; Suzuki, Ryusuke; Shirato, Hiroki; Shimizu, Satoru

doi:10.1016/j.ijrobp.2015.09.024

Cited by 90 publications

(79 citation statements)

References 35 publications

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“…They reported that the incidences of mean target position shifts > 2 mm and 5 mm were 40.8% and 4.2%, respectively. A similar conclusion was made by Takao Seishin et al,24 who evaluated the baseline shift by tracing the treatment couch of a real‐time tumor tracking system and noted that a longer treatment time may increase the incidence and magnitude of the baseline shift. Our results also supported their points.…”

Section: Discussionsupporting

confidence: 69%

Evaluation of the intra‐ and interfractional tumor motion and variability by fiducial‐based real‐time tracking in liver stereotactic body radiation therapy

Liang

Liu

Xue

et al. 2018

J Applied Clin Med Phys

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PurposeTumor motion amplitude varies during treatment. The purpose of the study was to evaluate the intra‐ and interfraction tumor motion and variability in patients with liver cancer treated with fiducial‐based real‐time tracking stereotactic body radiotherapy (SBRT).MethodsFourteen liver patients were treated with SBRT using a CyberKnife. Two to four fiducial markers implanted near the tumor were used for real‐time monitoring using the Synchrony system. The tumor motion information during treatment was extracted from the log files recorded by the Synchrony system. Logfile‐based amplitudes in the superior–posterior (SI), left–right (LR) and anterior–posterior (AP) directions were compared to the 4DCT‐based amplitudes. The intra‐ and interfraction amplitude variations and the incidence of baseline shifts were analyzed for 66 fractions administered to 14 patients.ResultsThe median (range) logfile‐based liver motion amplitudes for all patients were 11.9 (5.1–17.3) mm, 1.3 (0.4–4) mm and 3.8 (0.9–7.7) mm in the SI, LR and AP directions, respectively. Compared with the logfile‐based amplitude, the 4DCT‐based amplitude was underestimated (P < 0.05). The median (range) intra‐ and interfraction liver motion amplitude variations were 4.3 (1.6–6.0) mm (SI), 0.5 (0.2–2.2) mm(LR) and 1.5 (0.3–3.3) mm (AP) and 1.7 (0.5–4.6) mm (SI), 0.3 (0.1–3.0) mm (LR) and 0.7 (0.3–2.7) mm (AP), respectively. Baseline shifts exceeding 2 mm, 3 mm and 5 mm were observed in 27.3%, 7.6% and 3% of the measurements, respectively, within 10 min, and in 66.7%, 38.1% and 19%, respectively, within 30 min for the square root of the sum of the squares of the distances in the SI, LR and AP directions (3D). The tumor motion amplitude was found to be correlated with the baseline shift.ConclusionsMost patients showed significant intra‐ and interfraction liver motion amplitude variations over the entire course of radiation. More caution is needed for patients with large tumor motion amplitudes.

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Section: Discussionsupporting

confidence: 69%

Evaluation of the intra‐ and interfractional tumor motion and variability by fiducial‐based real‐time tracking in liver stereotactic body radiation therapy

Liang

Liu

Xue

et al. 2018

J Applied Clin Med Phys

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“…). For lung treatment, the incidence of a baseline‐shift/drift >3.0 mm was 6.0%, 15.5%, 14.0%, and 42.1% at 10 min after the start of irradiation for the LR, CC, and AP directions and Euclidian distance respectively . Prostate motion is mainly caused by rectal gas, and displacement during 10 min was significantly larger than that during the initial 2 min (Fig.…”

Section: Motion Monitoring Image Guided Particle Therapymentioning

confidence: 92%

“…Readjustment of treatment couch position during lung treatment in (a) left‐right ( LR ), (b) cranio‐caudal ( CC ), and (c) anterior‐posterior ( AP ) directions in 2016 measurements in 335 fractions of 68 patients. With permission …”

Section: Motion Monitoring Image Guided Particle Therapymentioning

confidence: 99%

Motion management in particle therapy

Mori¹,

Knopf

Umegaki

2018

Medical Physics

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In this review article, we introduced the importance of “motion management” in advanced particle therapy. Several publications have reported that organ motion causes dose distribution disturbances due to interplay and blurring effects. Furthermore, motion can result in target dose miss and unwanted dose to healthy structures around the target. To avoid these problems, motion should be assessed and monitored prior and during treatment. In this review article, we give an overview about clinically available motion monitoring systems. Based on the acquired motion information an adequate motion mitigation technique should be chosen. This article reviews the clinical status of motion mitigation techniques like rescanning, gating and tracking. A limited number of centers have now started the treatment of targets in the thorax and abdomen using scanned particle beams. Therefore, the establishment of guidelines for motion monitoring and motion mitigation will be essential in the coming years.

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“…Another frequently used technique for motion monitoring is the invasive implantation of fiducial markers for tumor tracking during radiation . Fiducial markers can be used for image‐based tracking, e.g.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of 2D and 3D ultrasound tracking algorithms and impact on ultrasound‐guided liver radiotherapy margins

et al. 2018

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Liver motion estimation and prediction during free-breathing from 2D ultrasound images can substantially reduce the in-plane motion uncertainty and hence treatment margins. Employing an accurate tracking method while avoiding non-linear temporal prediction would be favorable. This approach has the potential to shorten treatment time compared to breath-hold and gated approaches, and increase treatment efficiency and safety.

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Intrafractional Baseline Shift or Drift of Lung Tumor Motion During Gated Radiation Therapy With a Real-Time Tumor-Tracking System

Cited by 90 publications

References 35 publications

Evaluation of the intra‐ and interfractional tumor motion and variability by fiducial‐based real‐time tracking in liver stereotactic body radiation therapy

Evaluation of the intra‐ and interfractional tumor motion and variability by fiducial‐based real‐time tracking in liver stereotactic body radiation therapy

Motion management in particle therapy

Evaluation of 2D and 3D ultrasound tracking algorithms and impact on ultrasound‐guided liver radiotherapy margins

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