Intragastric administration of cyclo(Leu-Gly) inhibits the development of tolerance to the analgesic effect of morphine in the rat

Bhargava, Hemendra N.

doi:10.1016/0024-3205(88)90296-2

Cited by 29 publications

(3 citation statements)

References 11 publications

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“…The tripeptide Pro-Leu-Gly-NH 2 (MiF-1, MSH release-inhibiting factor) given once a day (1 mg/kg) alters the development of opiate tolerance (delayed tolerance to the analgesic action of morphine; Kastin et al 1979). The MIF-1 derivative cyclo (Leu-Gly) exerts the same activity even after intragastric administration (Bhargava 1988). All these findings suggest that several peptides and opiates administered outside the central nervous system (CNS) interact with regulatory processes in the CNS by influencing peripheral, sites and by transmitting information via afferent neurones.…”

Section: Km Important Afferent Ayfonomic Reflexes Input Akira Niijimamentioning

confidence: 99%

B-Afferents: A fundamental division of the nervous system mediating homeostasis?

Prechtl

Powley²

1990

Behav Brain Sci

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The peripheral nervous system (PNS) has classically been separated into a somatic division composed of both afferent and efferent pathways and an autonomic division containing only efferents. J. N. Langley, who codified this asymmetrical plan at the beginning of the twentieth century, considered different afferents, including visceral ones, as candidates for inclusion in his concept of the “autonomic nervous system” (ANS), but he finally excluded all candidates for lack of any distinguishing histological markers. Langley's classification has been enormously influential in shaping modern ideas about both the structure and the function of the PNS. We survey recent information about the PNS and argue that many of the sensory neurons designated as “visceral” and “somatic” are in fact part of a histologically distinct group of afferents concerned primarily autonomic function. These afferents have traditionally been known as “small dark” neurons or B-neurons. In this target article we outline an association between autonomic and B-neurons based on ontogeny, cell phenotype, and functional relations, grouping them together as part of a common reflex system involved in homeostasis. This more parsimonious classification of the PNS, made possible by the identification of a group of afferents associated primarily with the ANS, avoids a number of confusions produced by the classical orientation. It may also have practical implications for an understanding of nociception, homeostatic reflexes, and the evolution of the nervous system.

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Section: Km Important Afferent Ayfonomic Reflexes Input Akira Niijimamentioning

confidence: 99%

B-Afferents: A fundamental division of the nervous system mediating homeostasis?

Prechtl

Powley²

1990

Behav Brain Sci

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“…In addition, cyclo‐His‐Pro showed anti‐inflammatory effect by suppressing pro‐inflammatory necrosis factor (NF)‐ κ B signalling via Nrf2‐mediated hemeoxygenase‐1 activation . While others cyclic dipeptides containing glycine, as cyclo‐Leu‐Gly, have been studied extensively aiming toward the development of therapeutic agents for inhibit opiate‐induced tolerance …”

Section: Introductionmentioning

confidence: 99%

“…15 While others cyclic dipeptides containing glycine, as cyclo-Leu-Gly, have been studied extensively aiming toward the development of therapeutic agents for inhibit opiate-induced tolerance. 16 The cyclo-Gly-Pro peptide is naturally derived from the Nterminus of the insulin-like growth factor-1 (IGF-1). 17 Some beneficial activities, such as memory enhancement 12 and neuroprotection after ischemic brain injury, 18 have been attributed to cyclo-Gly-Pro.…”

Section: Introductionmentioning

confidence: 99%

Cyclo‐Gly‐Pro, a cyclic dipeptide, attenuates nociceptive behaviour and inflammatory response in mice

Ferro

Aquino

Brito

et al. 2015

Clin Exp Pharma Physio

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The present study aimed to investigate the antinociceptive and anti-inflammatory effects of the cyclic dipeptide cyclo-Gly-Pro (CGP) in mice. Antinociceptive activity was assessed by employing different pain models, such as formalin test, acetic acid-induced writhing, hot plate test, and carrageenan-induced hyperalgesia, in mice. The number of c-Fos-immunoreactive cells in the periaqueductal gray (PAG) was evaluated in CGP-treated mice. Anti-inflammatory activity was evaluated using paw oedema induced by carrageenan, compound 48/80, serotonin, and prostaglandin E2 (PGE2) and analyzed by plethysmometry. Quantitation of myeloperoxidase (MPO) in the paw was carried out to analyze the presence of neutrophils in the tissue. Intraperitoneal injection of CGP produced a significant inhibition in both neurogenic and inflammatory phases of formalin-induced pain. The antinociceptive effect of CGP, evaluated in the acetic acid-induced writhing test, was detected for up to 6 h after treatment. Further, in the hot plate test, antinociceptive behaviour was evoked by CGP, and this response was inhibited by naloxone. Animals treated with CGP did not present changes in motor performance. In CGP-treated mice there was an increase in the number of c-Fos-positive neurons in the periaqueductal gray. In another set of experiments, CGP attenuated the hyperalgesic response induced by carrageenan. Furthermore, CGP also reduced the carrageenan-increased MPO activity in paws. In addition, CGP also reduced the paw oedema evoked by compound 48/80, serotonin, and PGE2 . Taken together, these results may support a possible therapeutic application of the cyclic dipeptide cyclo-Gly-Pro toward alleviating nociception and damage caused by inflammation conditions.

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Antagonism of kappa opioid mediated effects in the rat by cyclo(Leu-Gly)

Bhargava

Ramarao

1989

Life Sciences

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Intragastric administration of cyclo(Leu-Gly) inhibits the development of tolerance to the analgesic effect of morphine in the rat

Cited by 29 publications

References 11 publications

B-Afferents: A fundamental division of the nervous system mediating homeostasis?

B-Afferents: A fundamental division of the nervous system mediating homeostasis?

Cyclo‐Gly‐Pro, a cyclic dipeptide, attenuates nociceptive behaviour and inflammatory response in mice

Antagonism of kappa opioid mediated effects in the rat by cyclo(Leu-Gly)

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