Intragastric Balloon Treatment for Obesity: Results of a Large Single Center Prospective Study

Štimac, Davor; Majanović, Sanja Klobučar; Turk, Tamara; Kezele, Borivoj; Licul, Vanja; Orlić, Željka Crnčević

doi:10.1007/s11695-010-0310-0

Cited by 39 publications

(38 citation statements)

References 24 publications

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“…After 6 months, mean BMI was 31.1 ± 7.2 and mean %EWL reached 41.6 ± 21.8%. Similar results were confirmed by our group in a series of 171 patients [12]. The mean BMI during balloon treatment declined from 41.9 ± 7.3 to 36.0 ± 7.9 with %EWL of 39.7 ± 23.6%.…”

Section: Restrictive Endoscopic Proceduressupporting

confidence: 88%

Endoscopic Approaches to Obesity

Štimac

Majanović²

2012

Dig Dis

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Given the emerging role of endoscopic procedures in the treatment of obesity and rapid changes in endoscopic technologies and techniques, this review considers the current state of endoscopic management of obesity. Endoluminal interventions performed entirely through the GI tract by using flexible endoscopy offer the potential for an ambulatory weight loss procedure that may be safer and more cost- effective compared with current surgical approaches. Endoscopic techniques attempt to mimic the anatomic features of bariatric surgery. Accordingly, there are two main endoscopic weight loss modalities – restrictive and malabsorptive. Restrictive procedures act to decrease gastric volume by space-occupying prosthesis and/or by suturing or stapling devices, while malabsorptive procedures tend to create malabsorption by preventing food contact with the duodenum and proximal jejunum. The former include intragastric balloon treatment, endoluminal vertical gastroplasty, transoral gastroplasty and transoral endoscopic restrictive implant system, while the latter include duodenojejunal bypass sleeve. Gastroduodenojejunal bypass sleeve is a combination of both procedures. Except for intragastric balloon, all mentioned procedures are rather new, tested on a small number of human subjects, with a high rate of success, but with limited knowledge on safety and long-term efficacy. The role of gastric electrical stimulation and intragastric injections of botulinum toxin in obesity treatment is also considered as is the role of minimally invasive bariatric endoscopic interventions.

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Section: Restrictive Endoscopic Proceduressupporting

confidence: 88%

Endoscopic Approaches to Obesity

Štimac

Majanović²

2012

Dig Dis

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“…Patients in our study experienced only metabolic effects. Stimac et al [7] also demonstrated there that there were no significant differences in LDL and total cholesterol concentration.…”

Section: Discussionmentioning

confidence: 93%

“…A cinética da perda de peso foi avaliada em dois momentos e contextos distintos: após a remoção do balão e depois do periódo de follow-up (PFU), que variou entre 6-12 meses. Eficácia definida como perda de peso 10% após PFU de [6][7][8][9][10][11][12] 16 foram excluidos (7 por intolerancia) e 35 entraram no estudo, dos quais 83% foram seguidos durante PFU. A perda de peso média (PPM) e % de excesso de peso perdido (EPP) na altura de remoção do BIG foi de 11.94 kg e 42.16%, respetivamente; após PFU, a PPM foi de 8.25 kg e o EPP foi 30.27%.…”

Section: Introductionunclassified

“…However, permanent weight loss is frequently difficult to achieve [6], and the availability of safe and effective weight loss therapies is limited [2]. The conventional treatments, such as a calorie-restricted diet, regular physical activity, and behavioral modification, are frustrating procedures which take a long time before any significant result can be observed [7,8].…”

Section: Introductionmentioning

confidence: 99%

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Intragastric Balloon for Obesity Treatment: Safety, Tolerance, and Efficacy

Silva¹,

Proença²,

Rodrigues³

et al. 2017

GE Port J Gastroenterol

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Background: Obesity is an increasing worldwide problem associated with a vast number of comorbidities. Decreasing body weight by only 5-10% has been shown to slow and even prevent the onset of obesity-related comorbidities. Between pharmacological therapy and bariatric surgery a great variety of endoscopic techniques are available, the most common being intragastric balloon (IGB). The purpose of this study was to assess the safety, tolerance, and kinetics of IGBs in weight loss. The kinetics of weight loss were evaluated in 2 different contexts and phases: after the IGB's removal and after follow-up that varied between 6 and 12 months. Successful weight loss was defined as ≥10% weight loss after 6-12 months. Methods: The study included 51 patients who had undergone Orbera® IGB placement between September 2014 and February 2016. Inclusion criteria were age between 18 and 65 years; body mass index (BMI) 28-35 with severe obesity-related disorders; or BMI 35-40. The IGB was removed 6 months later. All patients were followed for a minimum period of 6-12 months. Results: Of 51 patients, 16 were excluded (7 due to intolerance) and 35 patients entered the study, of which 83% were followed for more than 6-12 months. The average weight loss (WL) and % excess WL (%EWL) after 6 months of treatment were 11.94 kg and 42.16%, respectively. At 6-12 months, after removal of the IGB, the mean WL was 8.25 kg and %EWL was 30.27%. Nineteen patients attained a WL of ≥10% the baseline value at IGB removal and 12 maintained their weight below this threshold during the 6-12 following months. Conclusions: After temporary IGB implantation in overweight or obese individuals, a WL that was ≥10% of weight at baseline was achieved in 54.3% and sustained at 6-12 months in 41.4% of participants. IGBs are an attractive intermediate option between diet and exercise programs and bariatric surgery. In general, IGB placement is a safe and well-tolerated procedure.

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“…Stimac et al [35] in prospective studies involving 171 patients after BIB confirmed the effectiveness of the procedure as a method of weight reduction, at the same time obtaining substantial improvement in blood pressure, glycaemia and triglycerides level. However, the reduction of total cholesterol and low-density lipoproteins, and the increase in high density lipoproteins were not observed.…”

Section: Discussionmentioning

confidence: 85%

Assessment of the Effect of Dietary Modifications and Bioenteric Intragastric Balloon Treatment on the Changes of Some Morphological and Biochemical Parameters in Obese Patients

Balejko

Plust

2018

Ann Nutr Metab

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Obesity is the most common disease of affluence of the XXI century. According to WHO (World Health Organization), it is defined as a chronic metabolic disorder manifested by excessive accumulation of adipose tissue with high tendency for familial occurrence. According to WHO, obesity reaches epidemic proportions in many countries. High BMI (Body Mass Index) correlates with coexisting diseases. Traditional dietetic treatment often does not bring any results. A form of conservative (non-surgical) support for patients in fighting with obesity is the reduction of stomach volume by bioenteric intragastric balloon (BIB) treatment. The aim of the work was to develop a diet with anti-inflammatory properties, well-tolerated by the patients after BIB treatment. An American diet was modified by changing the composition of fatty acids, increasing anti-oxidative potential and adding synbiotics for patients treated with BIB. Chemical analysis of reconstructed food ratios of recommended diet was performed, analysing the content of micronutrients, composition of fatty acids, antioxidative capacity, reducing power and the content of polyphenols. Improvement in anthropometric measurement results and satisfying body weight loss were obtained, while preserving fat-free body mass. Improvement in the parameters of lipid metabolism was also observed, that is, decrease in total CH (cholesterol) and TG (triglycerides), and normalized concentration of HDL (high density lipoproteins) and LDL (low density lipoproteins) fractions. Reduced concentration of glucose in blood and lower blood pressure was also noted. Performed study confirms the effectiveness of complex treatment with BIB and properly adjusted individualized diet. Observations and own experience allow to deduce that patients who resign from systematic contact with a dietician cannot maintain reduced body weight. Abandoning previous habits is the only way to maintain the effect of weight loss. Most importantly, the change in patients’ awareness and consequent behaviour in the future are crucial. Even though genes may contribute to obesity, environmental factors mainly determine the possibility of the disease to occur. Therefore, the change of patients’ lifestyle after body weight reduction will decide on their fate.

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Intragastric Balloon Treatment for Obesity: Results of a Large Single Center Prospective Study

Cited by 39 publications

References 24 publications

Endoscopic Approaches to Obesity

Endoscopic Approaches to Obesity

Intragastric Balloon for Obesity Treatment: Safety, Tolerance, and Efficacy

Assessment of the Effect of Dietary Modifications and Bioenteric Intragastric Balloon Treatment on the Changes of Some Morphological and Biochemical Parameters in Obese Patients

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