Intrageneric and Intergeneric Interactions Developed by Oral Streptococci: Pivotal Role in the Pathogenesis of Oral Diseases

Chen, Yandi; Li, Yuqing; Zou, Jing

doi:10.21775/cimb.032.377

Cited by 3 publications

(3 citation statements)

References 158 publications

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“…However, "coadhesion" usually refers to a situation in which one microorganism is fixed to a surface and the coadhering microorganism is suspended (Ruhl et al, 2014). Binding is extremely important in the formation of multispecies biofilms, and depends on the adhesins expressed on the surface of one bacterium and the complementary polysaccharide-containing receptors expressed by the other species (Chen et al, 2019). S. gordonii, which occurs widely in oral microbial biofilms, can coaggregate with Actinomyces (Mohammed et al, 2018), Fusobacterium (Mutha et al, 2018), Streptococcus (Choo et al, 2021), and Veillonella (Zhou P. et al, 2021), and plays an important role in the formation of biofilms.…”

Section: Bacterial Interactions During Biofilm Formationmentioning

confidence: 99%

The Oral Microbiota: Community Composition, Influencing Factors, Pathogenesis, and Interventions

et al. 2022

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The human oral cavity provides a habitat for oral microbial communities. The complexity of its anatomical structure, its connectivity to the outside, and its moist environment contribute to the complexity and ecological site specificity of the microbiome colonized therein. Complex endogenous and exogenous factors affect the occurrence and development of the oral microbiota, and maintain it in a dynamic balance. The dysbiotic state, in which the microbial composition is altered and the microecological balance between host and microorganisms is disturbed, can lead to oral and even systemic diseases. In this review, we discuss the current research on the composition of the oral microbiota, the factors influencing it, and its relationships with common oral diseases. We focus on the specificity of the microbiota at different niches in the oral cavity, the communities of the oral microbiome, the mycobiome, and the virome within oral biofilms, and interventions targeting oral pathogens associated with disease. With these data, we aim to extend our understanding of oral microorganisms and provide new ideas for the clinical management of infectious oral diseases.

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Section: Bacterial Interactions During Biofilm Formationmentioning

confidence: 99%

The Oral Microbiota: Community Composition, Influencing Factors, Pathogenesis, and Interventions

et al. 2022

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“…Interestingly, however, in the PCoA analysis, the 2.5% DMADDM, 1.25% DMAHDM and 2.5% DMAHDM groups were separated from the control group, demonstrating that QAMs-modified giomers also had the potential to regulate the microbial compositions of the S-ECC saliva-derived biofilms. We found the percentages of Streptococcus , which has been reported to play a fundamental role in the development of ECC [ 46 , 47 ], significantly reduced in the 2.5% DMADDM group and the 1.25% DMAHDM group. The 2.5% DMAHDM group also showed a slightly lower level of Streptococcus , though it was not statistically significant.…”

Section: Discussionmentioning

confidence: 79%

“…Veillonella is a commensal microbe in the oral cavity and its role in ECC is still unclear. Some researchers found that Veillonella could consume lactic acids and help alleviate the demineralization of dental tissues, while others found that its consumption of acids produced by Streptococcus might facilitate the growth of Streptococcus and biofilm formation [ 46 , 47 ]. The elevation in the relative abundance of Veillonella for the 2.5% DMAHDM group might be attributed to the reduction of other genera, especially Lactobacillus.…”

Section: Discussionmentioning

confidence: 99%

Novel Giomers Incorporated with Antibacterial Quaternary Ammonium Monomers to Inhibit Secondary Caries

et al. 2022

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The objective of this study was to develop novel modified giomers by incorporating the antibacterial quaternary ammonium monomers (QAMs), dimethylaminododecyl methacrylate (DMADDM) or dimethylaminohexadecyl methacrylate (DMAHDM) into a commercial giomer. The material performances including mechanical properties, surface characteristics, color data, cytotoxicity and fluoride release of the novel giomers were evaluated. Antibacterial activity against severe early childhood caries (S-ECC) saliva-derived biofilms was assessed by lactic acid production measurement, MTT assay, biofilm staining and 16S rRNA sequencing. A rat model was developed and the anti-caries effect was investigated by micro-CT scanning and modified Keyes’ scoring. The results showed that the material properties of the QAMs groups were comparable to those of the control group. The novel giomers significantly inhibited lactic acid production and biofilm viability of S-ECC saliva-derived biofilms. Furthermore, caries-related genera such as Streptococcus and Lactobacillus reduced in QAMs groups, which showed their potential to change the microbial compositions. In the rat model, lesion depth, mineral loss and scoring of the QAMs groups were significantly reduced, without side effects on oral tissues. In conclusion, the novel giomers incorporated with antibacterial QAMs could inhibit the cariogenic biofilms and help prevent secondary caries, with great potential for future application in restorative treatment.

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Expert consensus on early childhood caries management

Zou

et al. 2022

Int J Oral Sci

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Early childhood caries (ECC) is a significant chronic disease of childhood and a rising public health burden worldwide. ECC may cause a higher risk of new caries lesions in both primary and permanent dentition, affecting lifelong oral health. The occurrence of ECC has been closely related to the core microbiome change in the oral cavity, which may be influenced by diet habits, oral health management, fluoride use, and dental manipulations. So, it is essential to improve parental oral health and awareness of health care, to establish a dental home at the early stage of childhood, and make an individualized caries management plan. Dental interventions according to the minimally invasive concept should be carried out to treat dental caries. This expert consensus mainly discusses the etiology of ECC, caries-risk assessment of children, prevention and treatment plan of ECC, aiming to achieve lifelong oral health.

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Intrageneric and Intergeneric Interactions Developed by Oral Streptococci: Pivotal Role in the Pathogenesis of Oral Diseases

Cited by 3 publications

References 158 publications

The Oral Microbiota: Community Composition, Influencing Factors, Pathogenesis, and Interventions

The Oral Microbiota: Community Composition, Influencing Factors, Pathogenesis, and Interventions

Novel Giomers Incorporated with Antibacterial Quaternary Ammonium Monomers to Inhibit Secondary Caries

Expert consensus on early childhood caries management

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