1971
DOI: 10.1002/1097-0142(1971)28:5<1147::aid-cncr2820280510>3.0.co;2-l
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Intrahepatic arterial infusion with 5-fluorouracil

Abstract: Since 1964, 200 patients were treated with intra‐arterial 5‐FU infusion. Of them, 127 failed with intravenously injected 5‐FU, and 27 were unsuitable for such treatment as their involvement was so far advanced as to have jaundice due to extensive parenchymal involvement. In all but 12 patients, the catheter was placed percutaneously through the brachial artery. The criteria for improvement included at least a 6‐cm decrease in distance of the liver edge from the xiphoid or costal margin, a 50% decrease in the a… Show more

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Cited by 116 publications
(31 citation statements)
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“…These theories have led over the years to the development of hepatic artery ligation and various forms of cytotoxic perfusion techniques in the treatment of multiple colorectal liver metastases (Brennan et al, 1963;Almersjo et al, 1968Almersjo et al, , 1972Watkins et at., 1970;Murray-Lyon et al, 1970;Ansfield et al, 1971;Fortner et al, 1973;Ansfield, 1975). Unfortunately, the results of these techniques in improving symptom-free survival have been particularly disappointing and unpredictable.…”
mentioning
confidence: 99%
“…These theories have led over the years to the development of hepatic artery ligation and various forms of cytotoxic perfusion techniques in the treatment of multiple colorectal liver metastases (Brennan et al, 1963;Almersjo et al, 1968Almersjo et al, , 1972Watkins et at., 1970;Murray-Lyon et al, 1970;Ansfield et al, 1971;Fortner et al, 1973;Ansfield, 1975). Unfortunately, the results of these techniques in improving symptom-free survival have been particularly disappointing and unpredictable.…”
mentioning
confidence: 99%
“…Hepatic arterial infusion chemotherapy has been used for 2 decades to treat liver metastases from colon carcinoma [1][2][3][4][5][6][7][8]. Liver tumors derive their blood supply primarily from hepatic arteries rather than portal veins.…”
Section: Methodsmentioning
confidence: 99%
“…Locoregional chemotherapy has the dual aim of increasing the exposure of tumor-bearing areas to drugs while partially reducing the cytotoxic effects on the patient's healthy tissues (Ansfield et al, 1971;Ensminger et al, (1978). The recent interest shown in this therapeutic approach can be explained by better knowledge about pharmacokinetics, allowing more objective and rational use of drugs (Balis et al, 1983;Schabel et al, 1983) and by biotechnological progress in the field of implantable pumps (Blackshear et al, 1972) permitting chemotherapy infusions on an ambulatory basis.…”
mentioning
confidence: 99%
“…Long clinical experience has been gained with chemotherapy protocols administered by an intra-arterial hepatic (i.a.h.) route (Ansfield et al, 1971;Stagg et al, 1984;Ensminer et al, 1978). Use of the portal vein appears advisable for small liver metastases (Ackerman et al, 1969).…”
mentioning
confidence: 99%