Intrahepatic splenic tissue.

Abstract

Intrahepatic splenic tissue is uncommon being reported to date in three humans and one pig. This report is of a 54 year old man with chronic asthma who died from acute bronchial asthma. Twenty years previously he had undergone a splenctomy (the spleen was histologically normal). Necropsy revealed a well defined, smooth bordered, bilobed red mass on the left hepatic lobe; one lobe projected outwards the other was embedded in the liver. Histologically the mass was splenic tissue. This case of intrahepatic splenic tissue differing from the three human cases reported previously in that there was a common capsule beneath which splenic pulp directly abuts on hepatic tissue. This suggests that this case is more probably one of hyperplasia of congenitally ectopic splenic tissue following splenectomy rather than limited splenosis after implantation onto the serosal surface of splenic tissue released by trauma. Splenic ectopia should be considered in the differential diagnosis ofhepatic lesions detected post-splenectomy and the liver should be considered as a possible site of residual splenic tissue if splenic function returns following splenectomy. (7 Clin Pathol 1997;50:532-533)

Experimental splenosis in the liver and lung spread through the vasculature

“…Lymphocyte infiltration, in contrast, appears to depend on where the remaining reticular cells and reticular fibers have made a scaffold for lymphocyte homing. Several papers have examined the cytology of clinical intrahepatic splenosis (Davidson and Reid 1997;Lee et al 2002;Zhao and Xu 2004;Kang et al 2011;Sandri et al 2013). Zhao et al and Davidson et al did not show splenic fragments growing in the portal vein but indicated poor development of the white pulp and marked red pulp formation, while others simply mentioned the consistency of the red and white pulp regions.…”

Contribution of the single photon emission computed tomography with 99mTc red blood cells in splenosis

“…2 An alternative probability of intrahepatic splenosis is that the splenic tissue and cells migration to the subcapsular location in the liver through the blood or lymphatic vessels after trauma. 11 In this regards, Kwok et al 12 hypothesized that the migration of erythrocytic progenitor cells through the portal vein following traumatic splenic rupture could promote intrahepatic splenosis development. The presentation of splenosis after liver injury is unusual.…”

Hepatic Splenosis Diagnosed as Hepatocellular Carcinoma: Report of a Case

“…The majority of them were incidental findings, and in some preoperatively discovered cases, they were misdiagnosed as hepatic adenoma, focal nodular hyperplasia, or metastatic lesion from breast carcinoma. [1][2][3][4][5][6] The diagnosis of splenosis can be confirmed by a peripheral smear that will exhibit either a diminished number or absence of siderocytes, Howell-Jolly bodies, Heinz bodies, and pitted red blood cells consistent with the presence of functioning splenic tissue. Nuclear scans demonstrate an uptake of technetium sulfur colloid and heat-damaged technetium-labeled autologous red blood cells.…”

“…[1][2][3][4][5][6] We experienced one case of hepatic splenosis misdiagnosed preoperatively as hepatocellular carcinoma, and we herein report the clinical situation, the radiologic findings, and pathologic features.…”