Intraindividual variability in neurocognitive performance is associated with time-based prospective memory in older adults

Sullivan, Kelli L.; Woods, Steven Paul; Bucks, Romola S.; Loft, Shayne; Weinborn, Michael

doi:10.1080/13803395.2018.1432571

Cited by 20 publications

(14 citation statements)

References 58 publications

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“…For example, future work might examine patterns of intraindividual variability (i.e., a marker of cognitive control; Hultsch, MacDonald, & Dixon, 2002) in PM accuracy over time. Research shows that older adults, including PLWH, show higher intraindividual variability in cognitive performance cross-sectionally (e.g., Morgan et al, 2011), which is associated with lower time-based PM (Sullivan, Woods, Bucks, Loft, & Weinborn, 2018) and declines in medication adherence (e.g., Thaler et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Enhancing cue salience improves aspects of naturalistic time-based prospective memory in older adults with HIV disease.

Woods¹,

Morgan²,

Loft³

et al. 2021

Neuropsychology

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Objective: Older persons living with HIV (PLWH) disease commonly experience failures of time-based prospective memory (PM) in their daily lives. This study examined the benefits of providing strategic supports at encoding, monitoring, and cue detection for naturalistic time-based PM among older PLWH. Method: Participants included 116 older PLWH and 48 seronegatives who completed a baseline neuropsychological evaluation (see Woods et al., 2020), including a laboratory PM experiment that paralleled the design of the current naturalistic study. The naturalistic time-based PM task required participants to press a button on a portable PM response box 4 times per day for 1 month. PLWH were randomly assigned to an unsupported control condition or to an experimental group in which strategic processing was supported at encoding (implementation intentions and visualization), monitoring (content-free cuing), and/or cue detection (auditory alarm). The seronegative participants were all assigned to the unsupported control group. Results: In a model adjusting for age and affective disorders, PLWH who received all three supports in combination demonstrated moderately better naturalistic time-based PM accuracy as compared with PLWH controls. Both the cue detection and combination conditions were associated with markedly more precise response timing on the naturalistic time-based PM task. Supported PM accuracy as measured in the laboratory was positively associated with naturalistic PM accuracy among PLWH in the experimental groups. Conclusions: Providing strategic supports to enhance the cue salience of naturalistic time-based PM tasks may improve both the accuracy and timing with which older PLWH remember to perform time-based intentions.Editor's Note. Dr. Yeates served as the action editor for this article.

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Section: Discussionmentioning

confidence: 99%

Enhancing cue salience improves aspects of naturalistic time-based prospective memory in older adults with HIV disease.

Woods¹,

Morgan²,

Loft³

et al. 2021

Neuropsychology

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“…With regards to cognition, participants completed the Repeated Battery for the Assessment of Neuropsychological Status [RBANS, Sullivan et al (2018)] and they were all tested for ApoE status. Sampling preparation and storage details can be found in the EPAD lab manual (available online at http:// www.ep-ad.org).…”

Section: Epad Lcsmentioning

confidence: 99%

Virtual Cohorts and Synthetic Data in Dementia: An Illustration of Their Potential to Advance Research

Muñiz‐Terrera

Mendelevitch²,

Barnes

et al. 2021

Front. Artif. Intell.

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When attempting to answer questions of interest, scientists often encounter hurdles that may stem from limited access to existing adequate datasets as a consequence of poor data sharing practices, constraining administrative practices. Further, when attempting to integrate data, differences in existing datasets also impose challenges that limit opportunities for data integration. As a result, the pace of scientific advancements is suboptimal. Synthetic data and virtual cohorts generated using innovative computational techniques represent an opportunity to overcome some of these limitations and consequently, to advance scientific developments. In this paper, we demonstrate the use of virtual cohorts techniques to generate a synthetic dataset that mirrors a deeply phenotyped sample of preclinical dementia research participants.

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“…Higher IIV-dispersion has been linked to poorer microstructural integrity of white matter pathways in older adults (Halliday et al, 2019) and persons with mild TBI (Sorg et al, 2021), particularly the genu and the superior longitudinal fasciculus. Higher IIV-dispersion is also related to poorer global cognition (Morgan et al, 2011), executive dysfunction (Sullivan et al, 2018), and difficulties multitasking (Fellows & Schmitter-Edgecombe, 2015). Taken together, there is both a conceptual and empirical basis to suggest that IIV-dispersion may measure an aspect of cognition that is important to PM in PLWH.…”

Section: Introductionmentioning

confidence: 99%

“…Experimental studies show that the addition of PM intention can increase IIV-inconsistency during the ongoing task (e.g., Ball & Brewer, 2018; Joly-Burra et al, 2018). Correlational studies suggest that higher IIV-inconsistency is independently associated with lower event-based PM accuracy for both focal (e.g., Haynes et al, 2018; Schmitter-Edgecombe et al, 2020) and nonfocal (e.g., Ihle et al, 2017; Sullivan et al, 2018) cues. One study reported that IIV-dispersion is also negatively associated with time-based PM; specifically, Sullivan et al (2018) demonstrated that higher variability in scores across the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS; Randolph et al, 1998) showed a small, but independent association with poorer time-based PM in the laboratory and in daily life among 194 older Australians.…”

Section: Introductionmentioning

confidence: 99%

Lower prospective memory is associated with higher neurocognitive dispersion in two samples of people with HIV: A conceptual replication study

Mustafa

Woods

Loft

et al. 2023

J Int Neuropsychol Soc

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Objectives: People living with HIV (PLWH) often experience deficits in the strategic/executive aspects of prospective memory (PM) that can interfere with instrumental activities of daily living. This study used a conceptual replication design to determine whether cognitive intraindividual variability, as measured by dispersion (IIV-dispersion), contributes to PM performance and symptoms among PLWH. Methods: Study 1 included 367 PLWH who completed a comprehensive clinical neuropsychological test battery, the Memory for Intentions Test (MIsT), and the Prospective and Retrospective Memory Questionnaire (PRMQ). Study 2 included 79 older PLWH who completed the Cogstate cognitive battery, the Cambridge Prospective Memory Test (CAMPROMPT), an experimental measure of time-based PM, and the PRMQ. In both studies, a mean-adjusted coefficient of variation was derived to measure IIV-dispersion using normative T-scores from the cognitive battery. Results: Higher IIV-dispersion was significantly associated with lower time-based PM performance at small-to-medium effect sizes in both studies (mean r s = −0.30). The relationship between IIV-dispersion and event-based PM performance was comparably small in magnitude in both studies (r s = −0.19, −0.20), but it was only statistically significant in Study 1. IIV-dispersion showed very small, nonsignificant relationships with self-reported PM symptoms in both samples (r s < 0.10). Conclusions: Extending prior work in healthy adults, these findings suggest that variability in performance across a cognitive battery contributes to laboratory-based PM accuracy, but not perceived PM symptoms, among PLWH. Future studies might examine whether daily fluctuations in cognition or other aspects of IIV (e.g., inconsistency) play a role in PM failures in everyday life.

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Intraindividual variability in neurocognitive performance is associated with time-based prospective memory in older adults

Abstract: These results indicate that cognitive control, as indexed by IIV in neurocognitive performance, may play a role in naturalistic PM, as well as in highly strategic, but not automatic, laboratory-based PM among older adults.

Cited by 20 publications

References 58 publications

Enhancing cue salience improves aspects of naturalistic time-based prospective memory in older adults with HIV disease.

Enhancing cue salience improves aspects of naturalistic time-based prospective memory in older adults with HIV disease.

Virtual Cohorts and Synthetic Data in Dementia: An Illustration of Their Potential to Advance Research

Lower prospective memory is associated with higher neurocognitive dispersion in two samples of people with HIV: A conceptual replication study

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