Intral Ymphocytic Sodium Concentration: A Sensitive Index to Identify Young Subjects at Risk of Hypertension

Амбросиони, Е.; Costa, Francesco; Montebugnoli, Lucio; Borghi, Claudio; Vasconi, L.; Tartagni, F; Magnani, B

doi:10.3109/10641968109033693

Cited by 24 publications

(7 citation statements)

References 18 publications

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“…Different populations have shown different values for sodium-potassium cotransport; values in hypertensive subjects and their relatives were low in some studies 12 and high in others. 8 ' l3 Elevated values have been reported in hypertensive subjects and in their normotensive first-degree relatives for Na + ,K + -adenosine triphosphatase (ATPase) pump, 14 intralymphocytic sodium, 15 and intraerythrocytic sodium. 16 These reported studies suggest that cation measurements are associated with hypertension and may provide biochemical manifestations of a developing familial syndrome before blood pressure abnormalities are manifest.…”

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confidence: 99%

Genetic studies of cation tests and hypertension.

et al. 1987

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SUMMARY Several tests of cation concentration and transport are being studied among members of large Utah pedigrees as part of a study of the genetic and environmental determinants of essential hypertension. Corrected urinary sodium excretion and plasma sodium concentration correlated well in spouses and siblings (r = 0.21-0.54, p< 0.001), suggesting the effects of shared family environment (e.g., sodium intake). Intraerythrocytic sodium concentration and sodium-lithium countertransport showed no significant correlation in spouses and very significant correlations between siblings and between parents and offspring (r = 0.34-0.58, p<0.001), suggesting mostly genetic determination. Using maximum likelihood tests of different genetic models, both sodium-lithium countertransport and intraerythrocytic sodium showed predominantly polygenic determination (H 2 = 70%) and some possible major gene determinants (H 2 = 18-25%) for a total heritability of 89 to 95% for these characteristics. These data suggest both genes and shared family environment contribute to the familiality of cation tests. They also illustrate the need and utility of quantitative methods for objective analysis of pedigree data.

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confidence: 99%

Genetic studies of cation tests and hypertension.

et al. 1987

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“…24 Our previous experiments showed that the exaggerated response to stress exhibited by a large proportion of young subjects with borderline hypertension is related to their intralymphocytic sodium content. 14 We also observed that their pressor response to stimulation is less than that of patients with sustained hypertension but greater than that of normotensive subjects (both with and without familial hypertension).…”

Section: Discussionmentioning

confidence: 69%

Effects of moderate salt restriction on intralymphocytic sodium and pressor response to stress in borderline hypertension.

Ambrosioni¹,

Costa²,

Borghi³

et al. 1982

Hypertension

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SUMMARY The effects of a moderate dietary salt restriction on intralymphocytic sodium content and pressor response to stress (mental arithmetic, handgrip, and bicycle exercise) were tested in 25 young subjects with borderline hypertension. The study was performed by a randomized, cross-over, within-patient, experimental design. Diet did not significantly reduce blood pressure at rest but did so significantly in both systolic and diastolic blood pressure during stress and exercise. Variations in diastolic blood pressure induced by stimulation correlated significantly with intralymphocytic sodium content both before and during low-salt diet whereas no correlation was found in the case of systolic blood pressure and heart rate variations. These findings suggest that in young subjects with borderline hypertension, sodium homeostasis and blood pressure regulation are somehow interrelated, and that a moderate dietary salt restriction reduces both intralymphocytic sodium content and pressor response to adrenergic stimulation. This could be useful in preventing the development of sustained hypertension. (Hypertension 4: 789-794, 1982) KEY WORDS • hypertension • stress • sodium • diet • lymphocytes

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“…Intralymphocyte sodium concentration is higher in the offspring of hypertensive subjects [35], but these find ings must be interpreted with caution, since the experi mental procedure to prepare lymphocytes is more com plicated than that for RBC [36], Four phenomenologically distinct pathways of sodium and potassium transport in RBC have been studied in the offspring of essential hypertensives. (1) The ouabain-sen sitive Na+-K+ pump that extrudes 3 sodium ions in the exchanges of 2 potassium ions with the consumption of one molecule of ATP; (2) the furosemide and bumetamide sensitive Na+-K+-Cl~ cotransport that moves 1 Na+ ion coupled to 1 K+ ion in the same direction (both inward and outward) and operates only in the presence of Cl-ions; (3) the phloretin-sensitive Na+-Na+ exchange that exchanges 1 intracellular Na+ ion for 1 extracellular Na+ ion and thus does not perform net sodium transfer (it is usually measured as Na-Li countertransport), and (4) the ground membrane leak to Na+ and K+.…”

Section: Cell Membrane Transportmentioning

confidence: 99%