Intralesional Bleomycin for Warts

Kruter, Laura E.; Saggar, Vishal Raj; Akhavan, Alaleh; Patel, Parth; Umanoff, Nicole; Viola, Kate V.; Stebbins, William G.; Smith, Elizabeth C.; Akhavan, Arash; Cohen, Justine V.; Cohen, Steven R.

doi:10.1177/1203475415576860

Cited by 25 publications

(4 citation statements)

References 38 publications

(50 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bleomycin has been successfully used for the treatment of recalcitrant warts [ 11 ]. The most likely mechanism of action of this drug is the creation of unstable free radicals causing single-strand breaks and apoptosis [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…The most likely mechanism of action of this drug is the creation of unstable free radicals causing single-strand breaks and apoptosis [ 12 ]. Multiple bleomycin administration techniques have been studied with various success rates [ 11 , 13 ]. However, several intralesional bleomycin injections are generally necessary to obtain clearance of the warts [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Successful treatment of plantar warts with intralesional bleomycin and electroporation: pilot prospective study

Pasquali

Freites-Martínez

González

et al. 2017

Dermatol Pract Concept

View full text Add to dashboard Cite

BackgroundNumerous studies have been performed to evaluate the efficacy of intralesional bleomycin for the treatment of warts with inconsistent result. Nevertheless, it is well known that the cytotoxicity of bleomycin can be enhanced in vivo by 300 to 700-fold by electroporation.Objective and MethodsIn this article, we present an interventional, one-center, prospective case series, clinical trial of the effectiveness of intralesional bleomycin combined with electroporation for the treatment of plantar warts, in comparison to the use of intralesional bleomycin alone.ResultsThe study’s cohort included 12 men and 10 women, with a mean age of 53.8 years. A total of 22 warts were treated. In dividing the patients in two groups (complete remission against all the others) and analyzing the different outcomes in the two arms of patients, a statistical significant difference was found (p=0.0015), proving a greater efficacy of the treatment with bleomycin combined with ECT as opposed to bleomycin alone. Electroporation was always well tolerated by the patients with no discomfort.ConclusionsThis study serves as a basis for the application of novel protocols in the treatment of different benign and locally malignant skin lesion by means of electroporation.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Successful treatment of plantar warts with intralesional bleomycin and electroporation: pilot prospective study

Pasquali

Freites-Martínez

González

et al. 2017

Dermatol Pract Concept

View full text Add to dashboard Cite

show abstract

“…d) Bleomycin: For 40 years, warts have been treated topically with bleomycin, a cytotoxic drug used in systemic chemotherapy. Warts can either be injected with bleomycin solution or have it applied to the surface then stabbed into the wart [43] .…”

Section: C) 5-fluorouracil (5-fu)mentioning

confidence: 99%

Different modalities in the treatment of verruca

Amawy,

Hassan,

Maghraby

et al. 2023

Int. J. Dermatol. Venereology Leprosy Sci.

View full text Add to dashboard Cite

Verruca (wart) is a common proliferation of skin and mucosa duo to human papillomaviruses (HPV) infection. They might be as little as a few millimetres or as large as several centimetres. They might be skin-colored or brownish-gray in hue. There is no need for further histologic or virologic tests because the diagnosis has been made clinically. There isn't a particular antiviral treatment for HPV available right now, however, some medications on the market disrupt the viral life cycle. There are several wart therapies accessible, however there can often be inadequate backing for their benefit, whether they are taken alone or in combination. Damage to the infected epithelium that ends up in cell death, antigen exposure, presentation, and an immune response is the most conventional kind of therapy. The wart should thin out as a result of diminishing epidermal proliferation, or more particularly DNA replication, which additionally ought to prevent the propagation of new viruses. Although there is currently no entirely appropriate course of treatment that would ensure complete cure, without relapses, wart treatment is still exceedingly difficult in contemporary dermatology. The majority of treatment methods involve numerous uncomfortable procedures rather than concentrating on eliminating the viral agent that is the cause of the illness. The main justification for the continued use of traditional medical practises and cures is this. The part doctors play in the healing process is being reevaluated. Any medical practise should be built on a partnership between the doctor and the patient, where accountability is shared and decisions are made together.

show abstract

“…Ýòî îòêðûòèå ñòèìóëèðîâàëî ïîèñê íîâûõ ïðîäóêòîâ ìèêðîáíîãî ìåòàáîëèçìà, ïîòåíöèàëüíî îáëàäàþùèõ ïðîòèâîðàêîâîé àêòèâíîñòüþ. Â íàñòîÿùåå âðåìÿ ñðåäè ïðîòèâîîïóõîëåâûõ àíòèáèîòèêîâ íàèáîëüøåå ïðàêòè÷åñêîå ïðèìåíåíèå èìåþò àíòðàöèêëèíû (ïðèðîäíûå àíòèáèîòèêè -äàóíîðóáèöèí [3,4], äîêñîðóáèöèí [5,6], àêëàðóáèöèí [7,8], ïîëóñèíòåòè÷åñêèå -èäàðóáèöèí [9,10], ýïèðóáèöèí [11,12], ñèíòåòè÷åñêèå àíàëîãè -àìðóáèöèí [13,14]), à òàêaeå áëåîìèöèíû [15,16], àêòèíîìèöèí D [17,18], ìèòðàìèöèí (àóðåîëîâàÿ êèñëîòà) [19] è ìèòîìèöèí [20]. Íåäàâíî ðàçðåøåíû ê ïðèìåíåíèþ 2 íîâûõ ïðîòèâîîïóõîëåâûõ ïðåïàðàòà íà îñíîâå àíòèáèîòèêîâ: â 2007 ã.…”

mentioning

confidence: 99%